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| 1 | Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department显示文摘BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian population.METHODS:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and December2007.Individual MEWS was calculated based on vital signs parameters on arrival at ED.Outcomes of mortality and ICU/HD admission were obtained from hospital records.The ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was assessed.Sensitivity,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous studies.RESULTS:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥4.Their mean age was 61.4 years(SD 18.1) with a male to female ratio of 1.10.Of the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to HD.The area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting mortality.CONCLUSION:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED. | Le Onn Ho Huihua Li Nur Shahidah Zhi Xiong Koh Papia Sultana Marcus Eng Hock Ong | 2013 | World Journal of Emergency Medicine2013，4，4： | 12 |
| 2 | Preparation of Chitin-PLA laminated composite for implantable application显示文摘The present study explores the possibilities of using locally available inexpensive waste prawn shell derived chitin reinforced and bioabsorbable polylactic acid(PLA)laminated composites to develop new materials with excellent mechanical and thermal properties for implantable application such as in bone or dental implant.Chitin at different concentration(1e20%of PLA)reinforced PLA films(CTP)were fabricated by solvent casting process and laminated chitin-PLA composites(LCTP)were prepared by laminating PLA film(obtained by hot press method)with CTP also by hot press method at 160C.The effect of variation of chitin concentration on the resulting laminated composite's behavior was investigated.The detailed physico-mechanical,surface morphology and thermal were assessed with different characterization technique such as FT-IR,XRD,SEM and TGA.The FTIR spectra showed the characteristic peaks for chitin and PLA in the composites.SEM images showed an excellent dispersion of chitin in the films and composites.Thermogravimetric analysis(TGA)showed that the complete degradation of chitin,PLA film,5%chitin reinforced PLA film(CTP2)and LCTP are 98%,95%,87%and 98%respectively at temperature of 500C.The tensile strength of the LCTP was found 25.09 MPa which is significantly higher than pure PLA film(18.55 MPa)and CTP2 film(8.83 MPa).After lamination of pure PLA and CTP2 film,the composite(LCTP)yielded 0.265e1.061%water absorption from 30 min to 24 h immerse in water that is much lower than PLA and CTP.The increased mechanical properties of the laminated films with the increase of chitin content indicated good dispersion of chitin into PLA and strong interfacial actions between the polymer and chitin.The improvement of mechanical properties and the results of antimicrobial and cytotoxicity of the composites also evaluated and revealed the composite would be a suitable candidate for implant application in biomedical sector. | Romana Nasrin Shanta Biswas Taslim Ur Rashid Sanjida Afrin Rumana Akhter Jahan Papia Haque Mohammed Mizanur Rahman | 2017 | Bioactive Materials2017，2，4： | 4 |
| 3 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 4 | Control Algorithm Based on Limit Cycle Oscillator-FLL for UPQC-S with Optimized PI Gains显示文摘This paper involves a limit cycle oscillator-frequency lock loop(LCO-FLL)based control algorithm for unified power quality controllers-S type(UPQC-S)for compensation of reactive power,to maintain a unity power factor,regulate constant voltage at the PCC,mitigate sag,swell and to eliminate harmonics.In this approach,an extraction of fundamental in-phase and quadrature components for the estimation of reference signals are taken from the LCO-FLL circuit.The control LCO-FLL provides a high grade of protection against sag-swell voltages,unbalance loading and harmonics present in the utility grid.In addition to that,it has advantageous characteristics of synchronization with the grid frequency at any previously mentioned conditions without use of phase locked loops or trigonometric functions.Other advantages of the LCO-FLL are to give useful information to estimate fundamental components from a highly polluted grid scenario.The values obtained from the JAYA optimization algorithm are used to fine-tune the proportional integral(PI)controller gains,so that it maintains DC link voltage to the desired level.The mean square error(MSE)is employed as an objective function for optimizing the error between actual and reference values.The control algorithm based on LCO-FLL is developed in MATLAB/Simulink software and it is tested for power conditioning features. | Sabha Raj Arya Sayed Javed Alam Papia Ray | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 2 |
| 5 | Phosphate Glass Fibre Composites for Bone Repair显示文摘We investigate high-modulus degradable materials intended to replace metals in biomedical applications.These are typicallycomposites comprising a polylactide(PLA)matrix reinforced with phosphate glass fibres,which provide reinforcementsimilar to E-glass but are entirely degradable in water to produce,principally,calcium phosphate.We have made compositesusing a variety of fibre architectures,from non-woven random mats to unidirectional fibre tapes.Flexural properties in theregion of 30 GPa modulus and 350 MPa strength have been achieved-directly comparable to quoted values for human corticalbone.In collaboration with other groups we have begun to consider the development of foamed systems with structures mimickingcancellous bone and this has shown significant promise.The fibres in these foamed structures provide improved creepresistance and reinforcement of the pore walls.To date the materials have exhibited excellent cellular responses in vitro andfurther studies are due to include consideration of the surface character of the materials and the influence of this on cell interaction,both with the composites and the glass fibres themselves,which show promise as a standalone porous scaffold. | Andrew J.Parsons Ifty Ahmed Papia Haque Ben Fitzpatrick Muhammad I.K.Niazi Gavin S.Walker Chris D.Rudd | 2009 | Journal of Bionic Engineering2009，6，4： | 2 |
| 6 | Infilled frames:developments in the evaluation of cyclic behaviour underlateral loads 显示文摘 | Cavaleri L Fossetti M Papia M | 2005 | Structural Engineering and Mechanics2005，21，4： | 1 |
| 7 | Gaetano russo compressive concrete strain at buckling of longitudinal reinforcement显示文摘 | PAPIA M | 1989 | Journal of Structural Engineering1989，115，2： | 1 |
| 8 | Seismic response of braced frames with and without friction dampers 显示文摘 | Colajann P Papia M | 1995 | Engng Struct1995，17，2： | 1 |
| 9 | Steel-concrete bond in lightweight fiber reinforced concrete under monotonic and cyclic actions 显示文摘 | Campione G Cucchiara C Mendola L L Papia M | 2005 | Engineering Structures2005，27，6： | 1 |
| 10 | Bonding between oxide ceramics and adhesive cement systems: a systematic re- view 显示文摘 | Papia E Larsson C du Toit M | 2014 | J Biomed Mater Res B Appl Biomater2014，102，2： | 1 |
| 11 | Effectiveness of stirrups and steel fibers as shear reinforcement显示文摘 | CUCCHIARA C MENDOLA L L PAPIA M | 2004 | Cement and Concrete Composites2004，26，7： | 1 |
| 12 | A new dynamic identification technique: application to the evaluation of the equivalent strut for infilled frames显示文摘 | CAVALERI L PAPIA M | 2003 | Engineering Structures2003，25，7： | 1 |
| 13 | Degradation Dynamics of Chlorfenapyr Residue in Chili, Cabbage and Soil显示文摘 | PAPIA DITYA S P DAS P K SARKAR | 2010 | Bull Environ Contam Toxicol2010，84，： | 1 |
| 14 | Genetics and genomics of melanoma显示文摘 | Papia G Lynda C | 2009 | Expert Rev Dermatol2009，4，2： | 1 |
| 15 | Hypertonic sa-line resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection显示文摘 | Papia G Burrows LL Sinnadurai S | 2008 | Surgery2008，144，5： | 1 |
| 16 | Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection 显示文摘 | Papia G Burrows LL Sinnadurai S | 2008 | Surgery2008，144，5： | 1 |
| 17 | Infection in hospitalized trauma patients : incidence, risk factors, and complications 显示文摘 | Papia G McLellan B A E1-Helou P | 1999 | Trauma1999，47，5： | 1 |
| 18 | Molecular analysis of the genetic variation among penicillin-susceptible and penicillin-resistant streptococcus penumoniae sertypes in canada显示文摘 | Louie M Louie L Papia G | 1999 | Infect dis1999，1，4： | 1 |
| 19 | Modeling of horizontal tube-bundle absorbers of absorption cooling system显示文摘 | SULTANA Papia WIJEYSUNDERA N E H O J C | 2007 | International Journal of Refrigeration2007，30，： | 1 |
| 20 | Effectiveness of stirrups and steel fibers as shear reinforcement 显示文摘 | Cucchiara C Mendola L L Papia M | 2004 | Cement & Concrete Composite2004，26，7： | 1 |
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