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| 1 | PPARγ activator,rosiglitazone:Is it beneficial or harmful to the cardiovascular system?显示文摘Rosiglitazone is a synthetic agonist of peroxisome proliferator-activated receptor γ which is used to improve insulin resistance in patients with typeⅡdiabetes.Rosiglitazone exerts its glucose-lowering effects by improving insulin sensitivity.Data from various studies in the past decade suggest that the therapeutic effects of rosiglitazone reach far beyond its use as an insulin sensitizer since it also has other benefits on the cardiovascular system such as improvement of contractile dysfunction,inhibition of the inflammatory response by reducing neutrophil and macrophage accumulation,and the protection of myocardial injury during ischemic/reperfusion in different animal models.Previous clinical studies in typeⅡdiabetes patients demonstrated that rosiglitazone played an important role in protectingagainst arteriosclerosis by normalizing the metabolic disorders and reducing chronic inflammation of the vascular system.Despite these benefits,inconsistent findings have been reported,and growing evidence has demonstrated adverse effects of rosiglitazone on the cardiovascular system,including increased risk of acute myocardial infarction,heart failure and chronic heart failure.As a result,rosiglitazone has been recently withdrawn from EU countries.Nevertheless,the effect of rosiglitazone on ischemic heart disease has not yet been firmly established.Future prospective clinical trials designed for the specific purpose of establishing the cardiovascular benefit or risk of rosiglitazone would be the best way to resolve the uncertainties regarding the safety of rosiglitazone in patients with heart disease. | Siripong Palee Siriporn Chattipakorn Arintaya Phrommintikul Nipon Chattipakorn | 2011 | World Journal of Cardiology2011，3，5： | 3 |
| 2 | The abdominal compartment syndrome:a complication with many faces显示文摘 | Beager P Nijsten M W Paling J C | 2001 | Neth J Med2001，58，： | 3 |
| 3 | Muhimodality gynecomastia repair by cross-chest power-assisted superficial liposuetion combined with endoscopic-assisted pull-through excision 显示文摘 | Ramon Y Fodor L Paled IJ | 2005 | Ann Plast Surg2005，55，6： | 1 |
| 4 | Low-amplitude, left vagus nerve stimulation significantly attenuates ventrieular dys- function and infarct size through prevention of mitochondrial dys- function during acute ischemia-reperfusion injury 显示文摘 | Shinlapawittayatorn K Chinda K Palee S | 2013 | Heart Rhythm2013，10，： | 1 |
| 5 | Perioperative anxiety and postoperative behaviours disturbaneeg or inhalation induction of anaesthesia显示文摘 | Aguilera IM Pale D Maeakin GH | 2003 | Paediatr Anaseth2003，13，6： | 1 |
| 6 | Influenza: old and new threats 显示文摘 | Pales P | 2004 | Nature Medicine Supplement2004，10，12： | 1 |
| 7 | Radiation dose and imagequality of prospective triggering with dual-source cardiac compu-ted tomography显示文摘 | Blankstein R Shah A Pale R | 2009 | Am J Cardiol2009，103，： | 1 |
| 8 | Minkowski's inequality for two variable Gini means显示文摘 | LOSONCZI L PALES Z | 1996 | Ata Sci Math (Szeged)1996，62，： | 1 |
| 9 | The forms of potassium and potassium adsorption in some virgin soils frorrl south-western Australia显示文摘 | pale Y Wong M T F Gilkes R J | 1999 | Australian Journal of Soil Research1999，37，4： | 1 |
| 10 | Converting a controlled vocabulary to Ontology:the case of GEM 显示文摘 | QhA Jian Paling Stephen | 2001 | Information Reseach2001，6，2： | 1 |
| 11 | The abdominal compartment syndrome:a complication with many faces 显示文摘 | Beager P Nigsten M W Paling J C | 2001 | Neth J Med2001，58，5： | 1 |
| 12 | Assessment of body composition in 8-11- year-old children by bioelectrical impedance 显示文摘 | Deurenberg P wan der Kooy K Paling P | 1989 | Eur J Clin Nutr1989，43，： | 1 |
| 13 | Use of I00 kV versus 120 kV in cardiac dual source computed tomography: effect on radiationdose and image quality 显示文摘 | Blankstein R Bolen MA Pale R | 2011 | Int J Cardiovasc Imaging2011，27，4： | 1 |
| 14 | Nitrogen uptake and allocation in the seagrass Amphibolis antarctica 显示文摘 | PEDERSEN M F PALING E I WALKER D I | 1997 | Aquatic Botany1997，56，2： | 1 |
| 15 | Defining the learning out comes of graduates from the medical school at the University of Barcelona (Catalonia, Spain) 显示文摘 | Pales J Cardellach F Estrach M | 2004 | Medical Teacher2004，26，3： | 1 |
| 16 | Low-ampli- tude, left vagus nerve stimulation significantly attenuates ventric- ular dysfunction and infarct size through prevention of mitoehou- drial dysfunction during acute ischemia-reperfusion injury 显示文摘 | Shinlapawittayatorn K Chinda K Palee S ct al | 2013 | Heart Rhythm2013，10，11： | 1 |
| 17 | Patterns of cerebral atrophy in dementia with lewy bodies using voxel-based morphometry显示文摘 | Burton E J Karas G Paling S M | 2002 | NeuroImage2002，17，2： | 1 |
| 18 | Acquisition of learning outcomes by students from the Medical School of the University of Barcelona (Catalonia, Spain): A student survey显示文摘 | Pales J Gual A Gomar C | 2008 | Medical Teacher2008，30，7： | 1 |
| 19 | Elliptical flexure hinges显示文摘 | Smith T S Badam I V G Pale J S | 1997 | Rev Sci Instrum1997，68，3： | 1 |
| 20 | Evaluating vegetative trans- plant success in Posidonia australis: a field trial with habitat enhancement显示文摘 | Campbell M L Paling E I | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
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