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| 1 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 2 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 3 | Dirac equation around a charged, rotating black hole 显示文摘 | PAGE D N | 1976 | Phys Rev: D1976，14，： | 2 |
| 4 | Microstructural evolution in reactionbonded silicon carbide显示文摘 | Ness J N Page T F | 1986 | J Mater Sci1986，21，： | 1 |
| 5 | Changing epidemiology of small-cell lung cancer in the United States over the last 30 years :anal- ysis of the surveillance, epidemiologic ,and end results database 显示文摘 | Govindan R Page N Morgensztern D | 2006 | J Clin Oncol2006，24，28： | 1 |
| 6 | Design of the optical communication demonstrator instrument optical system显示文摘 | PAGE N | 1994 | SPIE1994，2123，： | 1 |
| 7 | Preliminary investigations into the super-critical carbonation of cement pastes显示文摘 | SHORT N R PURNELL P PAGE C L | 2001 | J Mater Sci2001，36，1： | 1 |
| 8 | Super-critical carbonation of glass fiber reinforced cement (Part 1 ) : Mechanical tes ring and chemical analysis显示文摘 | PURNELL P SHORT N R PAGE C L | 2001 | Composites (Part A)2001，32，12： | 1 |
| 9 | HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus 显示文摘 | Page N Gros F Schall N | 2011 | Ann Rheum Dis2011，70，5： | 1 |
| 10 | Changing epidemiology of small-cell lung cancer in the United States over the last 30years:Analysis of the Surveillance,Epidemiolngic and End-Results database显示文摘 | Govindan R Page N Morgensztern D et a1 | 2006 | J Clin Oncol2006，24，28： | 1 |
| 11 | The direct electro- winning of gold from dilute cyanide leach liquors 显示文摘 | Brandon N P Mahmood M N Page P W | 1987 | Hydrometal- lurgy1987，18，3： | 1 |
| 12 | Evaluation of marker-assisted selection through computer simulation 显示文摘 | EDWARDS M D Page N J | 1994 | Theor Appl Genet1994，88，： | 1 |
| 13 | Changing epidemiology of small-cell lung cancer in the United States over the last 30 years:analysis of the surveillance,epidemiologic,and end results database显示文摘 | Govindan R Page N Morgensztern D | | 0，，28： | 1 |
| 14 | Strong decays of strange quarkonia 显示文摘 | Barnes T Black N Page P R | 2003 | Phys Rev D2003，68，05： | 1 |
| 15 | Changingepidemiology of small cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, Epidemiologic, and End results database显示文摘 | Govindan R Page N Morgensztern D | 2006 | J Clin Oncol2006，21，28： | 1 |
| 16 | Changing epidemiology of small-cell lung cancer in the United States over the last 30 years:analysis of the surveillance,epidemiologic,and end results database显示文摘 | Govindan R Page N Morgensztern D | 2006 | Clin Oncol2006，24，28： | 1 |
| 17 | Disk--Accretion onto a Black Hole I Time--Averaged Structure of Accretion Disk 显示文摘 | PAGE D N THORNE K S | 1974 | ApJ1974，191，： | 1 |
| 18 | The influence of different cement on chloride_induced corrosion of reinforcing steel显示文摘 | Page C L Short N R Holden W R | 1986 | Cement and Concrete Research1986，16，： | 1 |
| 19 | Role of External Signals in Regulating the Pre-penetration Phase of Infection by the Rice Blast Fungus Magnaporthe grisea显示文摘 | JELITTO T C PAGE H A READ N D | 1994 | Planta1994，194，： | 1 |
| 20 | Microstructural evolution in reaction-bonded silicon carbide显示文摘 | NessJ N Page T F | 1986 | J Mater Sci1986，21，4： | 1 |
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