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| 1 | Rectal hepatoid carcinoma with liver metastases in a patient affected by ulcerative colitis显示文摘BACKGROUND:Hepatoid tumors(HTs)are rare extra-hepatic neoplasms with the histological features, biochemical profile and,sometimes,even clinical course of hepatocellular carcinoma.We present a case of rectal hepatoid adenocarcinoma with metachronous liver metastases. METHODS:Four months after total procto-colectomy for a rectal adenocarcinoma(Astler-Coller C2),a 42-year-old man with ulcerative colitis showed hypoechoic masses in the hepatic parenchyma by abdominal ultrasonography. Carcinoembryonic antigen was normal,but alpha- fetoprotein was 32 000μg/L.Fine-needle biopsy revealed that liver masses were positive for hepatocellular carcinoma. The patient underwent left hepatectomy and alcoholisation of a small deep nodule in segment 8. RESULTS:Immunohistochemistry and albumin mRNA in situ hybridization suggested that the nodules were metastases of a HT.The patient was well during the first 6 months and refused any adjuvant chemotherapy.He died from liver failure 19 months after initial diagnosis. CONCLUSIONS:HT is a rare colon cancer.The preoperative diagnosis of this tumor requires a high degree of suspicion,the availability of a panel of immunohistochemical markers,and a certain amount of luck.The prognosis is poor despite an aggressive andmultimodal therapeutic strategy.So far,none of the hypotheses proposed about the origin and the biology of these tumors is convincing. | Giacomo Borgonovo Francesco Razzetta Michela Assalino Emanuela Varaldo Maria Puglisi Paola Ceppa | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 5 |
| 2 | Colon cancer stem cells:Controversies and perspectives显示文摘Tumors have long been viewed as a population in which all cells have the equal propensity to form new tumors,the so called conventional stochastic model.The cutting-edge theory on tumor origin and progression,tends to consider cancer as a stem cell disease.Stem cells are actively involved in the onset and maintenance of colon cancer.This review is intended to examine the state of the art on colon cancer stem cells(CSCs),with regard to the recent achievements of basic research and to the corresponding translational consequences.Specific prominence is given to the hypothesized origin of CSCs and to the methods for their identification.The growing understanding of CSC biology is driving the optimization of novel anti-cancer targeted drugs. | Maria Ausiliatrice Puglisi Valentina Tesori Wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 3 | Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study显示文摘 | Claudio Terzano Vittoria Conti Fabio Di Stefano Angelo Petroianni Daniela Ceccarelli Elda Graziani Salvatore Mariotta Alberto Ricci Antonio Vitarelli Giovanni Puglisi Corrado De Vito Paolo Villari Luigi Allegra | 2010 | Lung2010，，4： | 2 |
| 4 | Colonoscopic evaluation of hematochezia in low and average risk patients for colorectal cancer:A prospective study显示文摘AIM: To relate the endoscopic findings in patients with hematochezia with regard to age in “low and average risk” for colorectal cancer (CRC) and to localize signifi cant lesions in order to identify patients who need sigmoidoscopy or total colonoscopy. METHODS: This prospective study was performed in an open access GI endoscopy unit. Out of 4322 consecutive patients undergoing colonoscopy, 918 reported hema- tochezia. The fi nal study group comprized 180 patients aged below 45 and 237 over 45. Main exclusion criteria were a 1st-degree family history of colorectal carcinoma, patients reporting blood mixed with stools and/or pro- gressive colonic symptoms, or patients who had under- gone colon surgery for neoplastic lesions. RESULTS: Total colonoscopy could be performed in 96% of patients. Abnormal findings were observed in 34.3% of the younger and in 65.7% of the older ones. Findings were the presence of polyps in the distal colon (n = 2) and IBD in the proximal colon (n = 29) in the group of the younger patients, and polyps (n = 15), IBD (n = 13), and carcinoma (n = 6, 4 of the lesions were located proximal to the splenic flexure) in the elderly. Our f indings suggest that the diagnostic potential of total colonoscopy in patients younger than 45 referring scant hematochezia, is not mandatory. By exploring only the distal tract of the colon we have misdiagnosed two cases of IBD located in the ascending colon. In this group of patients additional risk factors must be identifi ed before performing a total colonoscopy. Regarding the patients older than 45 yr, the exploration of the distal colon would have led to our overlooking a carcinoma, two neoplastic polyps and one IBD located in the proximal colon. CONCLUSION: Young patients with scant hematochezia but without risk factors for neoplasia do not need a totalcolonoscopy, whereas is mandatory performing a total colonoscopy in older patients even in the presence of anal pathology. | Puglisi Carlo Russo Francesco Paolo Barbera Carmelo Incarbone Salvatore Aprile Giuseppe Bonanno Giacomo Russo Antonio | 2006 | World Journal of Gastroenterology2006，12，45： | 2 |
| 5 | Fluctuation–dissipation: Response theory in statistical physics显示文摘 | Umberto Marini Bettolo Marconi Andrea Puglisi Lamberto Rondoni Angelo Vulpiani | 2008 | Physics Reports2008，，4： | 2 |
| 6 | Capisterones A and B from the tropical green alga Penicillus capitatus:unexpected anti-fungal defenses targeting the marine pathogen Lindra thallasiae显示文摘 | Tan LT Jensen PR | 2004 | Tetrahedron2004，60，33： | 1 |
| 7 | Polymer-supported organic catalysts显示文摘 | Benaglia M Puglisi A Cozzi F | 2003 | Chem Rev2003，103，9： | 1 |
| 8 | Impact of closed-loop stimulation,overdrive pacing,DDDR pacing mode on atrial tachyarrhythmia burden in brady-tachy syndrome:A randomized study显示文摘 | Puglisi A Altamura G Capestro F | 2003 | Eur Heart J2003，24，： | 1 |
| 9 | Immunologic functions afterlaparoscopic cholecystectomy 显示文摘 | Puglisi F De Fazio M Capuano P | 2001 | Chir Ital2001，53，5： | 1 |
| 10 | Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury显示文摘 | Maria Ausiliatrice Puglisi Valentina Tesori Wanda Lattanzi Anna Chiara Piscaglia Giovanni Battista Gasbarrini Domenico M. D'Ugo Antonio Gasbarrini Ken-ichi Isobe | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 11 | Prognostic role of Ape/Ref-1 subcellular expression in stage Ⅰ-Ⅲ breast carcinomas显示文摘 | Puglisi F Barbone F Tell G | | 0，，01： | 1 |
| 12 | Thermal degradation of poly ( ethylene terephthalate) at the processing temperature 显示文摘 | Samperi F Puglisi C Alicata R Montando G | 2004 | Polym degrad stab2004，83，： | 1 |
| 13 | Anthocyanins accumulation and related gene expression in red orange fruit induced by low temperature storage显示文摘 | Piero A R L Puglisi I Rapisarda P | 2005 | Journal of Agricultural and Chemistry2005，，53： | 1 |
| 14 | Analysis of PWM techniques using uniform sampling in variable speed electrical drives with large speed range 显示文摘 | FRANZO G MAZZUCCHELLI M PUGLISI L | 1985 | IEEE Transactions on Industry Applications1985，21，4： | 1 |
| 15 | Design and kinematic analysis of 3PSS - 1S wrist for needle insertion guidance 显示文摘 | Lisandro J Puglisi Roque J Saltaren German Rey Portoles | 2013 | Robotics and Autonomous Systems2013，61，5： | 1 |
| 16 | Detection of tho- racotomy induced alterations in cell-and humoralmediated immune response 显示文摘 | Puglisi F Isitmangil T Balkanli K | 2002 | Eur J Cardiothorac Surg2002，21，3： | 1 |
| 17 | Soil burial and enzymatic degradation in solution of aliphatic co-polyesters显示文摘 | Rizzarelli P Puglisi C Montaudo G | 2004 | Polymer Degradation and Stability2004，85，： | 1 |
| 18 | Comparison of X-ray crystal structure of the 30S subunit-antibiotic complex with NMR structure of decoding site oligonucleotide-paromomycin complex显示文摘 | LYNCH SR GONZALEZ RL PUGLISI JD | 2003 | Structure (Camb)2003，11，1： | 1 |
| 19 | Expres- sion analysis in response to low temperature stress in blood oranges: implication of the flavonoid biosynthetic pathway 显示文摘 | Crifo Tiziana Puglisi Ivana Petrone Goffredo | 2011 | Gene2011，480，12： | 1 |
| 20 | Nonrobertsonian translocation t (6; 11) is associated with infertility in an oligozoospermic male显示文摘 | Perniee F Mazza G Puglisi D | 2002 | Fertil Steril2002，78，： | 1 |
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