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| 1 | Pre-and postoperative systemic hemodynamic evaluation in patients subjected to esophagogastric devascularization plus splenectomy and distal splenorenal shunt:A comparative study in schistomomal portal hypertension显示文摘AIM: To investigate the systemic hemodynamic effects of two surgical procedures largely employed for treatment of schistosomal portal hypertension. METHODS: Thirty-six patients undergoing elective surgical treatment of portal hypertension due to hepatosplenic mansonic schistosomiasis were prospectively evaluated. All patients were subjected to preoperative pulmonary artery catheterization; 17 were submitted to esophagogastric devascularization and splenectomy (EGDS) and 19 to distal splenorenal shunt (DSRS). The systemic hemodynamic assessment was repeated 4 d after the surgical procedure. RESULTS: Preoperative evaluation revealed (mean ± SD) an increased cardiac index (4.78 ± 1.13 L/min per m2),associated with a reduction in systemic vascular resistance index (1457 ± 380.7 dynes.s/cm5.m2). The mean pulmonary artery pressure (18 ± 5.1 mmHg) as well as the right atrial pressure (7.9 ± 2.5 mmHg) were increased,while the pulmonary vascular resistance index (133 ± 62 dynes.s/cm5.m2) was decreased. Four days after EGDS,a significant reduction in cardiac index (3.80 ± 0.4 L/min per m2,P < 0.001) and increase in systemic vascular resistance index (1901.4 ± 330.2 dynes.s/cm5. m2,P < 0.001) toward normal levels were observed. There was also a significant reduction in pulmonary artery pressure (12.65 ± 4.7 mmHg,P < 0.001) and no significant changes in the pulmonary vascular resistance index (141.6 ± 102.9 dynes.s/cm5.m2). Four days after DSRS,a non-significant increase in cardiac index (5.2 ± 0.76 L/min per m2) and systemic vascular resistance index (1389 ± 311 dynes.s/cm5.m2) was observed. There was also a non-significant increase in pulmonary artery pressure (19.84 ± 5.2 mmHg),right cardiac work index (1.38 ± 0.4 kg.m/m2) and right ventricular systolic work index (16.3 ± 6.3 g.m/m2),without significant changes in the pulmonary vascular resistance index (139.7 ± 67.8 dynes.s/cm5.m2). CONCLUSION: The hyperdynamic circulatory state observed in mansonic schistosomiasis was corrected by EGDS,but was maintained in patients who underwent DSRS. Similarly,the elevated mean pulmonary artery pressure was corrected after EGDS and maintained after DSRS. EGDS seems to be the most physiologic surgery for patients with schistosomal portal hypertension. | Roberto de Cleva Paulo Herman Luis Augusto Carneiro D’albuquerque Vincenzo Pugliese Orlando Luis Santarem William Abro Saad | 2007 | World Journal of Gastroenterology2007，13，41： | 9 |
| 2 | Liver transplantation:Fifty years of experience显示文摘Since 1963,when the first human liver transplantation(LT)was performed by Thomas Starzl,the world has witnessed 50 years of development in surgical techniques,immunosuppression,organ allocation,donor selection,and the indications and contraindications for LT.This has led to the mainstream,wellestablished procedure that has saved innumerable lives worldwide.Today,there are hundreds of liver transplant centres in over 80 countries.This review aims to describe the main aspects of LT regarding the progressive changes that have occurred over the years.We herein review historical aspects since the first experimental studies and the first attempts at human transplantation.We also provide an overview of immunosuppressive agents and their potential side effects,the evolution of the indications and contraindications of LT,the evolution of survival according to different time periods,and the evolution of methods of organ allocation. | Alice Tung Wan Song Vivian Iida Avelino-Silva Rafael Antonio Arruda Pecora Vincenzo Pugliese Luiz Augusto Carneiro D'Albuquerque Edson Abdala | 2014 | World Journal of Gastroenterology2014，20，18： | 8 |
| 3 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 4 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | | 0，，01： | 2 |
| 5 | Interaction of human plasma fibronectin with viral proteins of human immunodeficiency virus显示文摘 | Torre D Pugliese A Ferrario G | 1994 | FEMS Immunol Med Microbiol1994，8，2： | 1 |
| 6 | Total and subto -t- laparoscopic gastrectomy for adenocarcinoma 显示文摘 | Pugliese R Maggioni D Sansonna F etal | 2007 | SurgEndosc2007，21，1： | 1 |
| 7 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 8 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma 显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 9 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma 显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 10 | Total and subtotallaparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F et aZ | 2007 | Surg Endo-sc2007，，： | 1 |
| 11 | Usefulness of 64-slicemulti-slice computed tomography coronary ungiography to ass50 B in-stent restenosis显示文摘 | Cademartifi F Schuijf JD Pugliese F d a2 | 2007 | Am Coll Cardiol2007，49，22： | 1 |
| 12 | Total and subtotal Iaparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 13 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 14 | Total and subtotallaparoscopic gastrectomy for adenocarcinoma 显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg En-dose2007，21，1： | 1 |
| 15 | Total and subtotal laparoscopic gastrectomy for adenocarcinorna 显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
| 16 | Modeling and supporting grid scheduling显示文摘 | Pugliese A Talia D Yahyapour R | 2008 | J Grid Computing2008，，6： | 1 |
| 17 | Functional characterization of two isoforms of the P2Y-like receptor GPR17: GTP gamma S binding and electrophysiological studies in 1321N1 cells 显示文摘 | Pugliese AM Trincavelli ML Lecca D | 2009 | Am J Physiol Cell Physiol2009，297，4： | 1 |
| 18 | Update on the management of inflammatory bowel disease:specific role of adalimumab 显示文摘 | Guidi L Pugliese D Armuzzi A | 2011 | Clin Exp Gastroentero12011，4，： | 1 |
| 19 | Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme显示文摘 | Ricordi C Pugliese A | 2000 | Hum Gene Ther2000，11，7： | 1 |
| 20 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | 2007 | Surg Endosc2007，21，1： | 1 |
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