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| 1 | MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma显示文摘AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1or MUC5AC, and 9% expressed neither. High MUC1immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001),whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026),histological grading and stage of tumor represented the least probability of survival.CONCLUSION: MUC1 is overexpressed in liver flukeassociated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients. | Chanchai Boonla Banchob Sripa Peti Thuwajit Ubon Cha-On Anucha Puapairoj Masanao Miwa Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)显示文摘AIM To establish and dharacterize a nev cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand.METHODS: Fresh liver biopsy and bile specimens were obtained from a 65-year-old Thai woman with cholangiocarcinoma of the porta hepatis. After digestion, the cells were cultured in Ham's F12 media. The established cell line was then characterized for growth kinetics, cell morphology, imm unocytochemistry and cytogenetics. Tumorigenicity of the cell line was determined by heterotransplanting in nude mice. RESULTS: The primary tumor was a poorly differentiated tubular adenocarcinoma. Examination of the bile revealed malignant cells with O. viverrini eggs. The cholangiocarcinoma cell line KKU-100 was established 4 mo after the primary culture-population doubling time was 72 h. KKU-100 possesses compact and polygonal-shapedepithelial cells. Immunocytochemically, this cell line exhibited cytokeratin, EMA, CEA, and CA125, but not α-fetoprotein (AFP), CA19-9, desmin, c-met, or p53. Such protein expressions parallel those of the primary tumor. Cytogenetic analysis identified aneuploidy karyotypes with a modal chromosome number of 78 and marked chromosomal structural changes. Inoculation of KKU-100 cells into nude mice produced a transplantable, poorly differentiated aden-ocarcinoma, similar to the original tumor.CONCLUSION: KKJ-100 is the first egg-proven, Opisthorchis- associated cholangiocarcinoma cell line, which should prove useful for further investigations of the tumor biology of this cancer. | Banchob Sripa Saman Leungwattanawanit Takayuki Nitta Chaisiri Wongkham Vajarabhongsa Bhudhisawasdi Anucha Puapairoj Chongrak Sripa Masanao Miwa | 2005 | World Journal of Gastroenterology2005，11，22： | 4 |
| 3 | HLA-B27 subtypes in Northern and Northeastern Thais, Karens, and Bamars determined by a high-resolution PCR-SSP technique显示文摘 | Duanqchanehot M Puapairoj C Romphruk A | 2009 | Tissue Antigens2009，73，6： | 1 |
| 4 | Cytotoxic Activity of Cupane-type triterpenes from Glachidion sphaerogynum and Glachidion eriocarpum 显示文摘 | Puapairoj P Naengchomong W Kijjao A | 2004 | Planta Med2004，70，： | 1 |
| 5 | Effect of ethanol on paraquat toxicity in F 344 rats Food 显示文摘 | Puapairoj P Cui L Ogawa K | 1994 | Chem Toxicol1994，32，4： | 1 |
| 6 | Pulmonary actinomycosis presenting with prolonged fever and massive hemoptysis,a case report显示文摘 | Reechaipichitkul W Napaprasit T Puapairoj A | 2005 | Southeast Asian J Trop Med Public Health2005，36，： | 1 |
| 7 | Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais显示文摘 | Choonhakarn C Romphruk A Puapairoj C | 2002 | Int J Dermatol2002，41，6： | 1 |
| 8 | Effect of ethanol on paraquat toxicity in F344 rats显示文摘 | Puapairoj P Cui L Ogawa K | 1994 | Food Chem Toxicol1994，32，： | 1 |
| 9 | Analyses ofvaccination protocols for Leptospira interrogans serovar autumnalis in hamsters显示文摘 | Srikram A Wongratanacheewin S Puapairoj A | 2008 | Am J Trop Med Hyg2008，79，5： | 1 |
| 10 | Cytotoxic activi ty of lupane-type triterpenes from Glachidion sphaerogynum and Glachidion eriocarpum 显示文摘 | Puapairoj P Naengchomong W Kijjoa A | 2004 | Planta Med2004，70，6： | 1 |
| 11 | Palliative treat- ment of advanced cervical cancer with radiotherapy and thai herbal medicine as supportive remedy-analysis of survival 显示文摘 | Pesee M Kirdpon W Puapairoj A | 2013 | Asian Pac J Cancer Prev2013，14，3： | 1 |
| 12 | Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais 显示文摘 | Choonhakam C Romphruk A Puapairoj C | 2002 | Intern J Dermatol2002，41，： | 1 |
| 13 | Haplotype associations of the major histocompatibilty complex with psoriasis in Northeastern Thais显示文摘 | Choonhakam C Romphruk A Puapairoj C | 2002 | Int J Dermatol2002，41，6： | 1 |
| 14 | Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais显示文摘 | Amornrnat Romphruk Chintana Puapairoj | 2002 | International Journal of Dermatology2002，41，： | 1 |
| 15 | Overexpression of vitamin D receptor indicates a good prognosis for cholangiocarcinoma:implications for therapeutics 显示文摘 | Seubwai W Wongkham C Puapairoj A | 2007 | Cancer2007，109，12： | 1 |
| 16 | Effect of ethanol on paraquat toxicity in F 344 rats显示文摘 | Puapairoj P Cui L Ogawa K | 1994 | Food Chem Toxicol1994，32，4： | 1 |
| 17 | Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais显示文摘 | Choonhakarn C Romphruk A Puapairoj C | 2002 | Int J Dermatol2002，41，6： | 1 |
| 18 | Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis 显示文摘 | Puapairoj P Naengchomnong W Kijjoa A | 2005 | Planta Med2005，71，： | 1 |
| 19 | HLA-B*27subtypes in Northern and Northeastern Thais,Karens,andBamars determined by a high-resolution PCR-SSP technique显示文摘 | Duanqchanchot M Puapairoj C Romphruk A | 2009 | Tissue Antigens2009，73，6： | 1 |
| 20 | Cytotoxic Activity of lupine-type triterpenes from Glachidion sphaerogynum and Glachidion ericocarpum显示文摘 | Puapairoj P Naengchomong W Kijjoa A | 2004 | Planta Med2004，70，： | 1 |
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