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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Eccentrically braced frame links with reduced web sections 显示文摘 | Prinz G S Richards P W | 2009 | Journal of Con- structional Steel Research2009，65，10： | 1 |
| 3 | Adverse drug reac- tions(ADRs) associated with hospital admissions-elderly female patients are at highest risk显示文摘 | HOFER D C PRINZ E BEINDL W | 2011 | Ira J Cin Pharrnacol Ther2011，49，10： | 1 |
| 4 | Instructions for Motor Learning:Differential Effects of Internal Versus External Focus of Attention显示文摘 | Wulf G HβM Prinz W | 1998 | Journal of Motor Behavior1998，30，： | 1 |
| 5 | Directing Attention to Movement Effects Enhances Learning:A Review显示文摘 | Wulf G Prinz W | 2001 | Psychonomic Society2001，8，4： | 1 |
| 6 | Loss of circadian rhythmicity in blood testosterone levels with ageing in normal men 显示文摘 | BBEMNER W J VITIELLO M V PRINZ P N | 1983 | Clin Endocrinol Metal)1983，56，： | 1 |
| 7 | Mutations that allow disulfide bond formation in the cytosol of Escherichia coli显示文摘 | Derman A I Prinz W Belin D | 1993 | Sciene1993，262，： | 1 |
| 8 | Migratory orientation of pied flycatchers:interaction of stellar and magnetic information during ontogeny显示文摘 | Prinz K Wiltschko W | | 0，，： | 1 |
| 9 | Difficult problems in thyroid surgery显示文摘 | PRINZ R A ROSSI H L KIM A W | 2002 | Curr Probl Surg2002，39，1： | 1 |
| 10 | Population, households, and CO2 emissions 显示文摘 | MacKellar F L Lutz W Prinz C | 1995 | Population and Development Review1995，21，4： | 1 |
| 11 | Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia 显示文摘 | Ziegler G Prinz V Albrecht M W | 2009 | Biochim Biophys Acta2009，1792，： | 1 |
| 12 | Development of the Meso-and Macroporous Structure of Coals with Rank as Analysed with Small Angle Neutron Scattering and Adsorption Experiments 显示文摘 | Prinz D Pyckhout-Hintzen W Littke R | 2004 | Fuel2004，83，： | 1 |
| 13 | Influence of sulfate-reducing bacteria on cathodic protection显示文摘 | Grobe S Prinz W Schoneich HG Wingender J | 1996 | Werkstoffe und corrosion-materials and corrosion1996，47，8： | 1 |
| 14 | Directing Attention to Movement Effects Enhances Learning显示文摘 | Wulf G Prinz W | 2001 | Psychon Bull Rev2001，8，4： | 1 |
| 15 | Instructions for Motor Learning : Differential Effects of Internal Versus External Focus of Attention显示文摘 | Wulf G Hoe M Prinz W | 1998 | J Mot Behav1998，30，2： | 1 |
| 16 | Development of the meso-and macro-porous structure of coals with rank as analyzed with small angle neutron scattering and adsorption experiments显示文摘 | PRINZ D PYCKHOUT-HINTZEN W LITTKE R | 2004 | Fuel2004，83，45： | 1 |
| 17 | Linear relationship of re- fractive and biometric lenticular changes during accommodation in emmetropic and myopic eyes 显示文摘 | Bolz M Prinz A Drexler W Findl O | 2007 | Br J Ophthalmol2007，91，3： | 1 |
| 18 | Less lineages - more trait variation : phylogenetically clustered plant communities are functionally more diverse显示文摘 | Prinzing A Reiffers R Braakhekke W G | 2008 | Ecology Letters2008，11，8： | 1 |
| 19 | Rotational stability and pos- terior eapsule opaeifieation of a plate-haptie and an open-loop-hap- tic intraocular lens显示文摘 | Prinz A Neumayer T Buehl W | 2011 | J Cataract Refract Surg2011，37，2： | 1 |
| 20 | Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli显示文摘 | Prinz W A Belin D | 1993 | Science1993，262，： | 1 |
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