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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | 北京延庆断层崩积物记录的古地震事件释光测年研究显示文摘对北京延庆西羊房古地震探槽西壁采集的 10个崩积物和坡面沉积物样品进行了细颗粒 (4~ 11μm)多测片的红外释光 (IRSL)和绿光释光 (GLSL)测年。其中 4个样品既在中国地震局地质研究所用Daybreak仪器作了测量 ,也在澳大利亚Adelaide大学物理系用Ris 仪器作测量 ,其结果基本一致。该探槽剖面见 4个断层崩积楔 ,可视为 4次古地震事件的记录。释光测年表明 ,最新一个崩积楔有可能是公元 2 94年延庆东居庸村 6级地震的地质记录 ,大约在 1 7~2 0kaBP或 1 7~ 2 4kaBP期间至少有两次强烈地震事件。本文还对比了细颗粒GLSL与IRSL的测年结果。 | 赵华 Prescott J.R. 卢演俦 陈杰 尹功明 | 2001 | 中国地震2001，17，2： | 4 |
| 3 | 企业竞争,情报竞争——企业竞争情报系统的建立与服务显示文摘建立以项目为基础的竞争情报机制 建立以项目为基础的竞争情报调查和分析程序主要基于下列原因: 1.项目能系统地与企业的战略规划结合起来; 2. | John Prescott | 1999 | IT经理世界1999，0，12： | 4 |
| 4 | The DNA of Ciliated Protoza 显示文摘 | Prescott D M | 1994 | Microbiol Rev1994，58，： | 2 |
| 5 | Prognostic value of nutritional status in chronic obstructive pulmonary disease显示文摘 | Landbo C Prescott E Lange P | 1999 | Am J Respir Crit Care Med1999，160，6： | 2 |
| 6 | A Comparative Study of Carvedilol, Slow-Release Nifedipine, and Atenolol in the Management of Essential Hypertension显示文摘 | S. Hall R. I. Prescott R. J. Hallman S. Dixon R. E. Harvey S. G. Ball | 1991 | Journal of Cardiovascular Pharmacology1991，，： | 2 |
| 7 | Gap junctions containing alpha8-connexin (MP70) in the adult mammalian lens epithelium suggests a re-evaluation of its role in the lens显示文摘 | Dahm R van Marie J Prescott AR | 1999 | Exp Eye Res1999，69，： | 1 |
| 8 | In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice显示文摘 | Prescott RS Alsanea R Fayad MI | 2008 | J Endod2008，34，4： | 1 |
| 9 | Rhodococcus equi and im- munology of the foal 显示文摘 | Prescott JF Holmes MA Yager JA | | Vet Microbiol0，，： | 1 |
| 10 | Nonparametric kernel estimation applied to forecasting:an evaluation based on the bootstrap显示文摘 | Moschini G Prescott D M Stengos T | 1988 | Empirical Economics1988，13，3： | 1 |
| 11 | Effects of added glutamate on liking for novel food flavors 显示文摘 | PRESCOTT J | 2004 | Appetite2004，42，： | 1 |
| 12 | Determination of suit-able sample sizes for multi-patient based finite element studies显示文摘 | Radcliffe I A Prescott P Man H S | 2007 | Med Eng Phys2007，29，10： | 1 |
| 13 | Prognostic value of nutritional status in chronic obstructive pulmonary disease显示文摘 | Landbo C Prescott E Lange P | 1999 | Am J Respir Crit Care Med1999，160，6： | 1 |
| 14 | Strategic alliances andsocial capital: A multi dimensional view 显示文摘 | Koka BR Prescott J E | 2002 | Strategic Management Journal2002，，23： | 1 |
| 15 | Many actions of cyclooxygenase-2 in cellular dynamics and in cancer显示文摘 | CAO Y PRESCOTT S M | 2002 | J Cell Physiol2002，190，3： | 1 |
| 16 | Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study 显示文摘 | Wilson B J Watson MS Prescott G J | 2003 | BMJ2003，326，： | 1 |
| 17 | Chemo-prevention in superficial bladder cancer using mitomycin C: a survey of the practice patterns of British urologists 显示文摘 | Clarke NS Basu S Prescott S | 2006 | BJU Int2006，97，4： | 1 |
| 18 | Improved methodology and new thermoluminescence ages for the dune sequence in south-east Australia显示文摘 | Huntley D J Prescott J R | 2001 | Quaternary Science Reviews 20012001，，： | 1 |
| 19 | Microbial influence on tolerance and opportunities for intervention with prebiotics/ probiotics and bacterial lysates显示文摘 | Pfefferle PI Prescott SL Kopp M | 2013 | J Allergy Clin Immunol2013，131，6： | 1 |
| 20 | Continuous-infusion antipseudomonal beta-lactam therapy in patients with cystic fibrosis显示文摘 | Prescott WA Jr Gentile AE Nagel JL | 2011 | P T2011，36，11： | 1 |
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