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| 1 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 2 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | 氧化铝对铁矿石烧结质量和生产率的影响(英文)显示文摘烧结矿是现代高炉生产的主要含铁原料。合理控制入炉烧结矿的理化性能与冶金性能对高炉生产和稳定操作是很必要的。铁矿粉是烧结矿的主要原料,其化学成分和烧结料层内的热量条件在烧结过程中起着重要的作用。化学成分等参数也决定着烧结矿矿相结构和质量。由于含氧化铝原料的低反应性及其液相的高粘性,因此在人们的预料中高铝矿石对烧结矿结构组成的影响并不好。烧结混合料中的氧化铝在同化过程中需要消耗大量热量,延迟烧结过程。在确保高炉渣的流动性方面,氧化铝也需要消耗较大热量。不论是烧结还是高炉的生产实绩均表明,氧化铝是有害的。一般而言,高含铁量与低脉石的印度矿与其他矿石的不同特点就是氧化铝含量高。由于高品味铁矿石的消耗殆尽,使用可利用的烧结原料成为生产必需。因此,必须要掌握氧化铝的作用及其对烧结矿质量和生产过程的影响。实验室完成了不同氧化铝含量水平(2.00%~5.46%)的实验,可从中了解氧化铝在烧结矿矿物学、生产率、物理性能和冶金性能方面的影响。随着烧结矿中氧化铝含量的增加,残存赤铁矿、复合铁酸钙(SFCA)和孔隙率增加,而磁铁矿和硅酸盐比例下降。烧结生产率和烧结矿转鼓强度(TI)随着氧化铝含量上升而下降,反映烧结矿冶金性能的诸如低温还原粉化率(RDI)和还原率(RI)提高。 | T Umadevi S Prakash U K Bandopadhyay P C Mahapatra M Prabhu Madhu Ranjan | 2010 | 世界钢铁2010，，1： | 4 |
| 4 | Phenotypic plasticity in prostate cancer: role of ntrinsically disordered proteins显示文摘 | Steven M Mooney Mohit Kumar Jolly Herbert Levine Prakash Kulkarni | 2016 | Asian Journal of Andrology2016，18，5： | 2 |
| 5 | Structure,hardness and thermal stability of TiAlN and nanolayered TiAlN/CrN muhilayer film显示文摘 | HARISH C BARSHILIA M SURYA PRAKASH | 2005 | Vacuum2005，，2： | 1 |
| 6 | Synthesis of SAPO-34:high silicon incorporation in the presence of morpholine as tem- plate显示文摘 | Prakash A M Unnikrishnan S | 1994 | Journal of the Chemical Society Faraday Transac- tions1994，，90： | 1 |
| 7 | Movement of particles in compressed SF6 GIS with dielectric coated enclosure显示文摘 | Prakash K S Srivastava K D Morcos M M | 1997 | IEEE Transaction on Dielectrics and Electrical Insulation1997，4，3： | 1 |
| 8 | Dynamic re- sponse oI an unbalanced rotor supported on ball bear- ings显示文摘 | TIWARI M GUPTA K PRAKASH O | 2000 | Journal of Sound and Vibration2000，238，5： | 1 |
| 9 | Enhanced single copy integration events in corn via particle bombardment using low quantities of DNA显示文摘 | Lowe B A Shiva Prakash N Way M | 2009 | Transgenic Research2009，18，6： | 1 |
| 10 | Effect of radial internal clearance of a ball bearing on the dynamics of a balanced hori-zontal rotor显示文摘 | Tiwari M Gupta K Prakash O | 2000 | Journal of Sound and Vibration2000，238，5： | 1 |
| 11 | Tuning the reactivity of energetic nanoparticles by creation of a core-shell nanostructure显示文摘 | Prakash A Mccormick A V Zachariah M R | | 0，，07： | 1 |
| 12 | Large deletions and uniparental disomy detected by SNP arrays in adults with thoracic aortic aneurysms and dissections 显示文摘 | Prakash S Lemaire SA Bray M | 2010 | Am J Med Genet A2010，152，9： | 1 |
| 13 | Catalytic study of methanol-to-olefins conversion in four small-pore silicoalumino- phosphate molecular sieves : Influence of the structural type, nickel incorporation, nickel location, and nickel concentration 显示文摘 | Djieugoue Marie-Ange Prakash A M Kevan Larry | 2000 | Journal of Physical Chemistry B2000，104，27： | 1 |
| 14 | Dual site atrial pacing for the acute and chronic prevention of atrial fibrillation:A prospective study显示文摘 | Saksena S Hill M | 1995 | Am Coll Cardiol1995，25，： | 1 |
| 15 | Microsatellites in Malus X domestica(apple):abundance,polymorphism and cultivar identification 显示文摘 | Prakash S Zhu J M | 1997 | Theor Appl Genet1997，94，： | 1 |
| 16 | Prevention of recurrent atrial fibrillation with chronic dual-site right atrial pacing显示文摘 | Seksena S Prakash A Hill M | 1996 | J Am Coll Cardiol1996，28，： | 1 |
| 17 | Effect of radial internal clearance of a ball bearing on the dynamics of a balanced horizontal rotor显示文摘 | Tiwari M Gupta K Prakash O | 2000 | Journal of Sound and Vibration2000，238，： | 1 |
| 18 | In vitro inhibition of proliferation of estrogen-dependent and estrogen-independent human breast cancer cells treated with carotenoids or retinoids显示文摘 | Prakash P Russell R M Krinsky N I | 2001 | The Journal of Nutrition2001，131，： | 1 |
| 19 | Structural and dynamical properties of long-range correlated percolation显示文摘 | PRAKASH S HAVLIN S SCHWARTZ M | 1992 | Phys Rev A1992，46，： | 1 |
| 20 | Thermal buckling of simply supported functionally graded skew plates 显示文摘 | Ganapathi M Prakash T | 2006 | Composite Structures2006，74，2： | 1 |
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