|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 3 | Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review显示文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin | 2013 | World Journal of Hepatology2013，5，3： | 6 |
| 4 | Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis显示文摘瞄准:评估反应到 pegylated 干扰素高山哈在长期的血液透析上的长期的丙肝病人的 2a。方法:有长期的 C 肝炎的十个病人在这研究被注册。所有为超过 6 瞬间,积极 antiHCV 抗体和积极 PCR HCV-RNA 增加了 aminotransferases。我们管理了木钉干扰素高山哈 2a 为 48 wk 的 180 microg/wk。在治疗的 12 wk 以后,我们评估了生物化学、早的 virological 反应(EVR ) 。在治疗的结束,我们在我们评估了的治疗的结束以后评估了生物化学的反应和 24 wk 持续 virological 反应(SVR ) 。我们在治疗期间监视了副作用。结果:二个病人在治疗的开始的 12 wk 放弃了并且 2 在治疗的开始的 12 wk 以后。在治疗的 12 wk 以后, 7 从 8 个病人有生物化学的反应和 EVR, 1 有生物化学的反应但是坚持的病毒血。我们不得不在 2 种情况中把 pegylated 干扰素的剂量归结为 135 mug/wk。三(50%) 从 6,病人们在治疗的结束以后有 SVR 24 wk。Intention-to-treat 分析证明 3 从 10 个病人(30%) 有 SVR。副作用发生在大多数病人(像流感的症候群,血小板减少或 leucopoenia ) ,但是他们没强加治疗的中止。结论:在有木钉干扰素高山的治疗的 12 wk 以后哈在有长期的 C 肝炎的长期的血液透析上的病人的 2a (40 ku ) , EVR 在 87.5% 被获得(7/8 ) 盒子。SVR 在完成了治疗的 48 wk 的 50% 盒子(3/6 病人) 中被完成。 | Ioan Sporea Alina Popescu Roxana ■irli Ovidiu Golea CameliaTotolici Mirela Dǎnilǎ Corina Vernic | 2006 | World Journal of Gastroenterology2006，12，26： | 2 |
| 5 | Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome显示文摘AIM:To assess the feasibility of performing acoustic radiation force impulse(ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites.METHODS:Our study included 153 patients with ascites,mean age 58.8 ± 13.1 years.One hundred and fifteen(75.2%) patients had ascites in the context of cirrhosis,29(18.9%) had non-cirrhotic ascites(diagnosed by clinical,ultrasound,endoscopic and/or laparoscopic criteria) and in 9(5.9%) cases we could not establish the etiology of ascites.We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second(m/s).Among the 29 patients with non-cirrhotic ascites were included:20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation,7 acute pancreatitis with ascites which later resolved,and one case each of lymphatic ascites and ascites in the context of a liver abscess.In 11 of the 20 patients with peritoneal carcinomatosis,the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases.RESULTS:We could not obtain valid ARFI measurements in 5 patients(3.2%).The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites:3.04 ± 0.70 vs 1.45 ± 0.59 m/s(P < 0.001).For a cut-off value of 1.8 m/s for predicting cirrhosis(and ascites in the context of cirrhosis),as obtained in a previous study,ARFI had 98.1% sensitivity,86.2% specificity,96.4% positive predictive value,92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites.For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%.CONCLUSION:ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Mirela Dǎnilǎ Mǎdǎlina Sendroiu | 2011 | World Journal of Radiology2011，3，8： | 2 |
| 6 | Atomic force microscopy investigat ion o f radiation-induced DNA double strand breaks显示文摘 | Pang D Popescu G Rodgers J | 1996 | Scanning Microscopy1996，10，4： | 1 |
| 7 | Computation of Core Losses in Electrical Machines Using Improved Models for Laminated Steel显示文摘 | Ionel D M Popescu M Miller T J E | 2007 | IEEE Transactions on Industry Applications2007，43，6： | 1 |
| 8 | Blind separation of vibration signals and source change detection application to machine monitoring显示文摘 | POPESCU T D | 2010 | Applied Mathematical Modelling2010，34，11： | 1 |
| 9 | Infrared studies on SnO2and Pd/SnO2 显示文摘 | Amalric- Popescu D Bozon- Verduraz F | 2001 | Catalysis Today2001，70，13： | 1 |
| 10 | Mechanisticallyinspired design of FeⅢ - TAML peroxide - activating catalysts 显示文摘 | Popescu D L Chanda A Stadler M J | 2008 | J Am Chem Soc2008，130，12： | 1 |
| 11 | Using hidden Markov models to evaluate performance of cooperative spectrum sensing 显示文摘 | Treetmmuk D Popescu D C | 2013 | IET Communications2013，7，17： | 1 |
| 12 | 查看详情显示文摘 | D Collins N Gisin N Linden S Massar and S Popescu | | 0，，04： | 1 |
| 13 | Unbalancedmagnetic pull due to asymmetry and low-level staticrotor eccentricity in fractional-slot brushlesspermanent-magnet motors with surface-magnet andconsequent-pole rotors显示文摘 | Dorrell D G Popescu M lonel D M | 2010 | IEEE Transactions onMagnetics2010，46，7： | 1 |
| 14 | On the likelihoodbased approach to modulation classification显示文摘 | Hameed F Dobre O A Popescu D C | | 0，，12： | 1 |
| 15 | A new approach to modeling and control of a food extrusion process using artificial neural network and an expert system显示文摘 | Popescu O Popescu D C Wilder J Karwe M V | | 0，，1： | 1 |
| 16 | A best-fit model of power losses in cold rolled-motor lamination steel operating in a wide range of frequency and magnetization显示文摘 | Popescu M Ionel D M | 2007 | IEEE Transactions on Magnetics2007，43，4： | 1 |
| 17 | Subfemtosecond, coherent, relativistic, and ballistic electron bunches generated at coo and 2ω0 in high intensity laser-matter interaction显示文摘 | Popescu H Baton S D Amiranoff F | 2005 | Phys Plasmas2005，12，06： | 1 |
| 18 | Tear secretion following spherical and astigmatic excimer laser photo-refractive keratectomy显示文摘 | Siganos D S Popescu C N Siganos C S | 2000 | J Cataract Refract Surg2000，26，11： | 1 |
| 19 | Hydrothermal synthesis and characterization of some polycrystalline-iron oxides显示文摘 | Diamandescu L Mihaila T D Popescu P N | 1999 | Ceramics International1999，25，5： | 1 |
| 20 | Nonlocal Content of Quantum Operations显示文摘 | COLLINS D LINDEN N POPESCU S | 2001 | Phys Rev A2001，64，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员