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| 1 | 新生儿重症监护室医院感染预防策略显示文摘新生儿是医院感染的易感人群,医院感染能增加新生儿重症监护室(NICU)患儿的患病率、死亡率,延长住院时间,增加医疗费用,本文阐述了关于新生儿医院感染的预防和管理策略。
一、手卫生
手卫生是医务人员洗手、卫生手消毒、外科手消毒的总称。手卫生是降低医院感染最有效的方法。以下情况应遵守手卫生:接触患儿前后;从患儿污染的部位到清洁部位;进行侵袭性操作之前;接触患儿体液、排泄物、破损的皮肤、伤口敷料之后;直接接触患儿周围环镜后;摘除无菌或被污染的手套后。 | 卜祥芳 张欣 Polin RA Denson S Brady MT | 2014 | 中国新生儿科杂志2014，29，6： | 7 |
| 2 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 3 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | 疑似和确诊新生儿早发型败血症的管理显示文摘新生儿早发型败血症目前仍是导致早产儿发病和死亡的主要原因之一。由于缺乏特异性表现,各种实验室检查的阳性预测值不高,常导致延误治疗,而延长广谱经验性抗生素治疗(≥5天)与晚发型败血症、坏死性小肠结肠炎及死亡有关。本文目的是为处理疑似和确诊新生儿早发型败血症提供一个实用、有循证依据的方法。 | 周平 马晓樱 马丽亚 Polin RA | 2014 | 中国新生儿科杂志2014，29，3： | 3 |
| 5 | Consequences of coinfection with protective symbionts on the host phenotype and symbiont titres in the pea aphid system显示文摘在微生物和昆虫之间的共生协会是普遍的,并且几个共生者分享一样的主人个人,是经常的。因此,相互作用能发生在这些共生者之间,影响他们在有它的显型上的后果的主人以内的各自的丰富。这里,我们在豌豆蚜虫调查多重感染的效果, Acyrthosiphon pisum,它是主人一应尽并且几个容许的共生者。特别地,我们与 2 个保护的共生者学习 coinfection 的影响:Hamiltonella defensa,它对 parasitoids 授与保护,和 Rickettsiella viridis。各自的许多上的 Hamiltonella-Rickettsiella coinfection 的效果共生者,主人健康和敌人保护的功效被学习。在 2 个保护的共生者之间的不均匀的相互作用被发现了:什么时候他们 coinfect 一样的蚜虫个人,当 Hamiltonella 感染否定地影响调停 Rickettsiella 的保护的显型然而并非它的丰富时, Rickettsiella 感染在主人然而并非调停 Hamiltonella 的保护的显型以内影响了 Hamiltonella 丰富。怀有 2 个保护的共生者也减少了主人个人的幸存和肥沃。总的来说,这个工作在是可能的在自然产地影响共生协会的维护的共生者丰富和主人特点上加亮多重感染的效果。 | Melanie Leclair Sarah Polin Thibaut Jousseaume Jean-Christophe Simon Akiko Sugio Stephanie Morliere Takema Fukatsu Tsutomu Tsuchida Yannick Outreman | 2017 | Insect Science2017，24，5： | 2 |
| 6 | Discovery and preclinical antitumor efficacy evaluations of LY32262 and LY33169 显示文摘 | CORBETT TH WHITE K POLIN L | 2003 | Invest New Drugs2003，21，1： | 1 |
| 7 | Detection of soluble E-selectin,ICAM-1,VCAM-1,and L-selectin in the cerebral spinal fluid of patients after subarachnoid hemorrhage显示文摘 | Polin RS Bavbek M Shaffrey ME | 1998 | J Neurosurg1998，89，： | 1 |
| 8 | The role of pre-operative adjuvant treatment in the management of esthe-sioneuroblastoma: the University of Virginia experience显示文摘 | Polin RS Sheehan JP Chenelle AG | 1998 | Neurosurgery1998，42，5： | 1 |
| 9 | Efficacy of translum in alan-gioplasty for the management of symptomatic cerebral vasospasm following a neurysmal subarachnoid hemorrhage显示文摘 | Polin R S Coenen V A Hansen C A etal | 2000 | J Neurosurg2000，92，2： | 1 |
| 10 | The role of preoperative adjuvant treatment in the management of esthe- sioneuroblastoma: the University of Virginia experience显示文摘 | Polin RS Sheehan JP Chenelle AG | 1998 | Neurosurgery1998，42，5： | 1 |
| 11 | The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma:the University of Virginia experience显示文摘 | Polin RS Sheehan JP Chenelle AG | 1998 | Neurosurgery1998，42，5： | 1 |
| 12 | An empirical comparison of surface- based and volume- based group studies in neuroimaging显示文摘 | Tucholka A Fritsch V Poline JB | 2012 | Neuroimage2012，63，3： | 1 |
| 13 | Treatment and prevention of necrotizing enteroeolitis显示文摘 | Lee JS Polin RA | 2003 | Semin Neonatol2003，8，6： | 1 |
| 14 | Decompressive bifrontal craniectomy in the treatment severe refractory posttraumatic cerebral edema显示文摘 | Shaffrey ME Bogaev CA | 1997 | Neurosurgery1997，41，1： | 1 |
| 15 | Efficacy of transluminal angioplasty for the management of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage显示文摘 | Coenen VA Hansen CA | 2000 | J Neurosurg2000，92，： | 1 |
| 16 | The visual word form area: a prelexical representation of visual words in the fusiform gyrus 显示文摘 | Dehaene S Le-Clec'H G Poline JB | 2002 | Neuroreport2002，13，3： | 1 |
| 17 | A voxelbased method for the statistical analysis of gray and white matter density applied to schizophrenia显示文摘 | Wright I C McGuire P K Poline J B | 1995 | NeuroImage1995，2，4： | 1 |
| 18 | HLA-Cw* 0740:a new allele mistyped by generic sequencing and identified by allelic separation显示文摘 | Danzer M Polin H Schroder S | 2007 | Tissue Antigens2007，69，1： | 1 |
| 19 | Nonoliguric hyperkalemia in the premature infant weighing less than 1000 grams显示文摘 | Gruskay J Costarino AT Polin RA | | 0，，02： | 1 |
| 20 | A quantitative,randomized study evaluating three methods of mesenchymal stem cell delivery follow in myocardial infarction显示文摘 | Freyman T Polin G Osman H | | 0，，： | 1 |
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