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| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Evaluation of 100 laparoscopic varicocele operations with preservation of testicular artery and ligation of collateral vein in children and adolescents显示文摘 | Nyirady P Kiss A Pirot L | 2002 | Eur Urol2002，42，： | 1 |
| 3 | Giant left main cornary artery aneueyam in association with severe athenroselerotic cononary disease显示文摘 | Vranckx P Pirot L Benit E | 1997 | Cathet Cardiovasc Diagn1997，42，1： | 1 |
| 4 | Giant left main coronary artery aneurysm in association with severe atherosclerotic coronary disease显示文摘 | Vranckx P Pirot L Benit E | 1997 | Cathet Cardiovasc Diagn1997，42，1： | 1 |
| 5 | Induction of nuclear factor-kappa B and its downstream genes by TNF-alpha and IL-lbeta has a pro-apoptotic role in pancreatic beta cells 显示文摘 | Orris F Pirot P Naamane N | 2008 | D iabetologia2008，51，2： | 1 |
| 6 | The response of balanitis xerotica obliterans to local steroid application compared with placebo in children显示文摘 | Kiss A Csontai A Pirot L | 2001 | J Urol2001，165，1： | 1 |
| 7 | Laparoscopic varicocele operation: a chance to prevent the recurrence 显示文摘 | Pirot L Altorjay A | 1998 | Acta Chir Hung1998，37，3： | 1 |
| 8 | Anatomical and electrophysiological evidence for excitatory amino acid pathway from the thatamic mediodorsal nucleus to the prefrontal cortex in the rat显示文摘 | Pirot S Therese MJ Glowinski J | 1994 | Euro J Neurosci1994，6，7： | 1 |
| 9 | Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells显示文摘 | Ortis F Pirot P Naamane N | 2008 | Diabetologia2008，51，7： | 1 |
| 10 | Investigation of Chemical Interactions Between CSM and NBR显示文摘 | Markovic G Pirot | 2009 | Kautsehuk Gummi kunsttoffe2009，62，3： | 1 |
| 11 | Giant left main coronary artery aneurysm in association with severe at heroscl erotic coronary disease显示文摘 | Vranckx P Pirot L Benit E | 1997 | Cathet Cardiovasc Diagn1997，42，： | 1 |
| 12 | Pulmonary capillaritis with hemorrhage due to propylthiouraeil therapy in a child显示文摘 | Pirot AL Goldsmith D Pascasio J | 2005 | Pediatr Pulmonol2005，39，1： | 1 |
| 13 | Formulation, stability testing, and analytical characterization of melatonin-based preparation for clinical trial显示文摘A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens(0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to(i) prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and(ii) carry out a stability study in order to determine a use-bydate. Validation of preparation process was claimed as ascertained by mass uniformity of hard capsules.Multicomponent analysis by attenuated total reflectance Fourier transformed infrared(ATR-FTIR) of melatonin/microcrystalline cellulose mixture allowed to identify and quantify relative content of active pharmaceutical ingredients and excipients. Absolute melatonin content analysis by high performance liquid chromatography in 0.5 mg and 6 mg melatonin capsules was 93.6% ± 4.1% and 98.7% ± 6.9% of theoretical value, respectively. Forced degradation study showed a good separation of melatonin and its degradation products. The capability of the method was 15, confirming a risk of false negative < 0.01%. Stability test and dissolution test were compliant over 18 months of storage with European Pharmacopoeia. Preparation of melatonin hard capsules was completed manually and melatonin in hard capsules was stable for 18 months, in spite of low doses of active ingredient. ATR-FTIR offers a real alternative to HPLC for quality control of highdose melatonin hard capsules before the release of clinical batches. | Samira Filali Charlotte Bergamelli Mamadou Lamine Tall Damien Salmon Diane Laleye Carole Dhelens Elhadji Diouf Christine Pivot Fabrice Pirot | 2017 | Journal of Pharmaceutical Analysis2017，7，4： | 1 |
| 14 | Assessment of sodium hyaluronate gel as vehicle for intracameral delivery of cefuroxime in endophthalmitis prophylaxis显示文摘 | Uhart M Pirot F Boillon A | 2010 | Int J Pharm2010，398，12： | 1 |
| 15 | Giant left main coronary artery aneurysm in association with severe atherosclerotic coronary disease显示文摘 | Vranekx P Pirot L Benit E | 1997 | Cathet Cardiovasc Diagn1997，42，1： | 1 |
| 16 | Transcriptional regula-tion of the endoplasmic reticulum stress gene Chop in pan-creatic insulin-producing cells显示文摘 | Pirot P Ortis F Cnop M | 2007 | Diabetes2007，56，4： | 1 |
| 17 | Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells显示文摘 | Pirot P Ortis F Cnop M | 2007 | Diabetes2007，56，4： | 1 |
| 18 | Commonly used UV filter toxicity on biological functions:review of last decade studies显示文摘 | GILBERT E PIROT F BERTHOLLE V | 2013 | International Journal of Cosmetic Science2013，35，3： | 1 |
| 19 | Giant left main coronary artery aneurysm in association with severe atherosclerotic coronary disease显示文摘 | Vranckx P Pirot L Benit E | 1997 | Cathet Cardiovasc DIAGN1997，42，1： | 1 |
| 20 | Mediators and mechanisms of pancreatic beta-cell death in type1diabe-tes显示文摘 | Pirot P Cardozo A K Eizirik D L | 2008 | Arq Bras Endocrinol Metabol2008，52，2： | 1 |
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