|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation显示文摘B″蛋白质磷酸酶 2A (PP2A ) 的 /PR72 家庭一个重要 PP2A 家庭涉及多样的细胞的过程,并且特别地由钙绑定调整了到规章的子单元。在这个家庭的 PR70 子单元与房间部门控制 6 交往(Cdc6 ) ,为 DNA 复制的控制重要的一个房间周期管理者。这里,我们在 2.1 和 2.4 Å 的一个决定报导孤立的 PR72 和 trimeric PR70 holoenzyme 的水晶结构;,分别地并且在 Cdc6 dephosphorylation 的 vitro 描述。holoenzyme 结构表明 PR70 钙绑定主题之一直接联系支架子单元,导致在所有 PP2A holoenzymes 之中的最紧缩的支架子单元符合构造。PR70 也在活跃地点附近区别地绑在催化子单元,它被要求让 PR70 向 Cdc6 提高磷酸酶活动。我们的研究为 B″ 的唯一的规定提供一个结构的基础;由钙离子的 /PR72 holoenzymes,并且在 PP2A holoenzymes 之中为底层特性的精确控制建议机制。 | Nathan Wlodarchak Feng Guo Kenneth A Satyshur Li Jiang Philip D Jeffrey Tingwan Sun Vitali Stanevich Marc C Mumby Yongna Xing | 2013 | Cell Research2013，23，7： | 3 |
| 3 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 4 | A statistical-topographic model for mapping climatological precipitation over mountainous terrain 显示文摘 | Daly C Neilson R P Philips D L | 1994 | Journal of Applied Meteorology1994，33，： | 1 |
| 5 | Controlled tamponade of severe presacral venous hemorrhage use of breast implant sizer显示文摘 | Scott C Braley Philip D | 2002 | Dis Colon Rectum2002，45，1： | 1 |
| 6 | Accurate analytical method for the extraction of solar cell model parameters显示文摘 | Phang J C J Chan D S H Philips J R | 1984 | Electronics Letters1984，20，10： | 1 |
| 7 | The future of electrical and computer engineering education显示文摘 | Frederick C B Philip S D Susan L S | 2003 | IEEE Transactions on Education2003，46，4： | 1 |
| 8 | Consumption Visions in Consumer Decision Making显示文摘 | PHILIPS D M OLSON J C BAUMGARTNER H | 1995 | Advances in Consumer Research1995，，22： | 1 |
| 9 | Correlations between Tri halomethanes and Total Organic Halides Formed during Water Treatment 显示文摘 | PHILIP C S SHENGDER D C | 1989 | J AWWA1989，81，8： | 1 |
| 10 | Aqueous synthesis and characterization of CdS, CdS:Zn^2+ and CdS:Cu^2+ quantum dots显示文摘 | UNNI C PHILIP D SMITHA S L | 2009 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2009，72，4： | 1 |
| 11 | FT - IR, FT - Raman and SERS spectra of vitamin C 显示文摘 | YOHANNAN PANICKER C TRESA VARGHESE H PHILIP D | 2006 | Spectrochimica Acta A Mol Biomol Spectrosc2006，65，34： | 1 |
| 12 | Somenew insights into the sensing mechanism of palladium promoted Tin (IV) oxide sensor显示文摘 | Shik Chi Tsang Colin D A Bulpitt Philip C H Mitchell | 2001 | J Phys Chem B2001，105，： | 1 |
| 13 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 1显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，108，： | 1 |
| 14 | Development of spematozoa in the rhea显示文摘 | Philips D M Asa C S | 1989 | Anatomical Record1989，223，： | 1 |
| 15 | Assessment of constipation in long term care patients显示文摘 | Philips C Polakoff D Maue SK | 2001 | J Am Dir Assoc2001，2，4： | 1 |
| 16 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 3显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，110，： | 1 |
| 17 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 2显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，109，： | 1 |
| 18 | Ultrastructure of spermatozoa ofthe crested tinamou显示文摘 | Asa C S Philips D M Stover J | 1986 | Journal of ultrastructure and molecularstructure researchh1986，94，： | 1 |
| 19 | Synthesis,characterization,and hydrodesulfurization properties of silica supported molybde-num phosphide catalysts显示文摘 | Philips D C Sawhill S J | 2002 | J Catal2002，207，2： | 1 |
| 20 | Formulation of colored fiber blends from friele' s theoretical model 显示文摘 | Philips Invemizzi B Dupont D Caze C | 2002 | Color Research and Application2002，27，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员