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| 1 | The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma(英文)显示文摘Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c. 2756A> G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homoeysteine and folate metabolism in lymphoma tumorigenesis. | Linnebank M Schmidt S Kolsch H Linnebank A Heun R Schmidt-Wolf IG Glasmacher A Fliessbach K Klockgether T Schlegel U Pels H | 2004 | 中国神经肿瘤杂志2004，2，2： | 3 |
| 2 | Combustion of coal as a source of N2O emission显示文摘 | WOJTOWICZ M A PELS J R MOULIJN J A | 1993 | Fuel Process Technol1993，34，1： | 1 |
| 3 | Accuracy of maxi- mum flow rate for diagnosing bladder outlet obstruction can be estimated from the ICS nomogram 显示文摘 | IDZENGA T PEL JJ VAN MASTRIGT R | 2008 | Neurourol Urodyn2008，27，1： | 1 |
| 4 | Feature-based regis- tration of retinal images 显示文摘 | Pel E Augliere R A Timberlake G T | 1987 | IEEE Transactions on Medical Imaging1987，6，3： | 1 |
| 5 | Evolution of nitrogen functionalities in carbonaceous materials during pyrolysis 显示文摘 | PELS J R KAPTEIJN F MOULIJN J A | 1995 | Carbon1995，33，11： | 1 |
| 6 | Moisture transport in heated concrete, as studied by NMR, and ist consequences for fire spalling 显示文摘 | Heijden H H A Bijnen R M W van Pel L | 2007 | Cem Con Res2007，27，6： | 1 |
| 7 | NO and N2O decomposition over coal char at fluidized-bed combustion conditions显示文摘 | Ooms A C Pels J R | 1994 | Combustion and flame1994，99，： | 1 |
| 8 | NO and N2O decomposition over coal char at fluidized-bed combustion conditions 显示文摘 | Rodriguez-Mirasol J Ooms A C Pels J R | 1994 | Combustion and Flame1994，9，34： | 1 |
| 9 | The fate of nitrogen functionalities in coal during pyrolysis and combustion 显示文摘 | WOJTOWICZ M A PELS J R MOULIJN J A | 1995 | Fuel1995，74，4： | 1 |
| 10 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 11 | N2O Emission Control in Coal Combustion显示文摘 | Wojtowicz M A Pels J R Moulijn J A | 1994 | Fuel1994，73，9： | 1 |
| 12 | Evolution of nitrogen functionalities in carbonaceous materials during pyrolysis显示文摘 | Pels J R Kapteijn F Moulijn J A | 1995 | Carbon1995，33，： | 1 |
| 13 | Automated GC-MS analysis of raw biological samples:Application to fatty acid profiling of aquatic micro-organisms显示文摘 | Akoto L Pel R Irth H | 2005 | Journal of Analytical and Applied Pyrolysis2005，73，1： | 1 |
| 14 | Simultaneous detection and enumeration of viable lactic acid bacteria and bifidobacteria in fermented milk by using propidium monoazide and real-time PCR显示文摘 | GARCIA-CAYUELA T TABASCO R PELEZ C | 2009 | International Dairy Journal2009，19，6： | 1 |
| 15 | Virus and inactivated canine distemper virus induce incomplete immunity to canine distemper显示文摘 | Pel M J G Shek W R Shesberadan H | 1984 | Arch Virol1984，82，： | 1 |
| 16 | Evolution of nitrogen functionalities in carbonaceous, materials during pyrolysis显示文摘 | Pels J R Kapeteijn F Moulijn J A | 1995 | Carbon1995，33，16： | 1 |
| 17 | Spark ignition parameters of cryogenic hydrogen in oxygen and nitrogen mixture显示文摘 | Yate G B Pel A R | 1964 | Advance in Cryogenic Engineering 101964，，： | 1 |
| 18 | Evolution of nitrogen functionalities in carbonaceous materials during pyrolysis 显示文摘 | Pels J R Kapteun F Moulun J A | 1995 | Carbon1995，33，11： | 1 |
| 19 | Combustion of coal as a source of N2O emission显示文摘 | Wojtowicz M A Pels J R Moulijn J A | 1993 | Fuel Processing Technology1993，34，： | 1 |
| 20 | Environmental tax re- form and the double dividend : A meta - analytical per- formance assessment显示文摘 | Patuelli R Nijkamp P Pels E | 2005 | Ecological Economics Elsevi- er2005，55，4： | 1 |
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