|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Associations of leptin gene polymorphisms with production traits in pigs 显示文摘 | De Oliveira Peixoto J Facioni Guimar?es S E Savio Lopes P | 2006 | J Anita Breed Genet2006，123，6： | 1 |
| 3 | Absence of association between HPV DNA,TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China显示文摘 | Hsin Lu S Snijders P | 2001 | Cancer Lett2001，162，2： | 1 |
| 4 | Cystatin C: A Promising: Marker of Renal Function in Patients with Systemic Lupus Erythematosus? 显示文摘 | Peixoto L Aguiar P de Braganca R et aI | 2015 | Acta Med Port2015，28，3： | 1 |
| 5 | Assay of human interferon in Vero cells by several methods 显示文摘 | FERREIRA P C PEIXOTO M L SILVA M A | 1979 | J Clin Microbiol1979，9，4： | 1 |
| 6 | Concomitant life threatening lesions in a cirrhotic patient:the value of endoscopic treatment显示文摘 | Cancela E Ministro P Peixoto P | 2010 | Rev Esp Enferm-Dig2010，102，10： | 1 |
| 7 | Emergence of robustness against noise: A structural phase transition in evolved models of gene regulatory networks显示文摘 | Peixoto T P | 2012 | Physical Review E2012，85，04： | 1 |
| 8 | Peutz-Jeghers syndrome: capsule endoscopy to stage disease 显示文摘 | Antunes H Nascimento J Peixoto P | 2013 | Lancet2013，38，1： | 1 |
| 9 | Histone-deacetylases inhibitors: from TSA to SAHA显示文摘 | Peixoto P Lansiaux A | 2006 | Bull Cancer2006，93，1： | 1 |
| 10 | Extraeellular ATP and P2Yz receptors mediate intercellular Ca(z+ )waves induced by mechanical stimulation in submandibular gland cells:role of mitochondrial regulation of store operated Ca(2 +)entry显示文摘 | RYU S Y PEIXOTO P M WON J H | 2010 | Cell Calcium2010，47，1： | 1 |
| 11 | Clinical and morphologic changes in ewes and fetuses poisoned by Ipomoea carnea subspecies fistulosa显示文摘 | Armien A G Tokarnia C H Peixoto P V | 2011 | J Vet Diagn Invest2011，23，2： | 1 |
| 12 | Entropy budget of the atmosphere 显示文摘 | Peixoto J P Oort A H Tome A | 1991 | Journal of Geophysical Research1991，96，10： | 1 |
| 13 | Clini- cal and morphologie changes in ewes and futuses poi- soned by Ipomoea camea subspecies fistulosa显示文摘 | Armien A G Tokarnia C H Peixoto P V | 2011 | J Vet Diagn Invest2011，23，2： | 1 |
| 14 | Zooplankton in littoral waters of a tropical lake : a revisited biodiversity 显示文摘 | Maia-Barbosa P M Peixoto R S Guimaraes A S | 2008 | Braz J Biol2008，48，： | 1 |
| 15 | Molecular mechanisms involved in the angiotensin (l 7)/Mas signaling pathway in cardiomyocytes 显示文摘 | Dias Peixoto M F Santos R A Gomes E R Alves M N Alrneida P W Greco L | 2008 | Hypertension2008，52，： | 1 |
| 16 | Clini- cal and morphologic changes in ewes and fetuses poi- soned by Ipomoea carnea subspecies fistulosa显示文摘 | Armien A G Tokarnia C H Peixoto P V | 2011 | J Vet Diagn Invest2011，23，2： | 1 |
| 17 | Dexmedetomidine infusion during laparoscopic bariatric sur- gery : The effecton recovery outcome variables 显示文摘 | TUFANOGULLARI B WHITE P F PEIXOTO M P | 2008 | AnesthAna- lg2008，106，6： | 1 |
| 18 | Visual behaviors for real-time control of a binocular active vision system显示文摘 | Peixoto P Araujo H | 1997 | Control Engineering Practice1997，5，10： | 1 |
| 19 | Physics of climate显示文摘 | Peixoto J P Oort A H | 1984 | Reviews of Modern Physics1984，56，： | 1 |
| 20 | Spontaneous latency in a rabbit model of pulmonary tuberculosis 显示文摘 | Subbian S Tsenova L O'Brien P Yang G Kushner NL Parsons S Peixoto B Fallows D Kaplan G | 2012 | Am J Pathol2012，181，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员