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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 3 | Oral refeeding in mild acute pancreatitis:An old challenge显示文摘Although the idea that pancreas rest has long been considered as a very relevant topic in acute pancreatitis (AP)therapy,the right time and type of diet to be offered to patients recovering from an acute attack are a great challenge to clinicians who treat this condition.Fortunately,the last decade was noted for several trials looking for the best answer to the question:'when and how to start oral refeeding in AP?'It is well known that 80%of patients present with mild disease characterized by usually uncomplicated clinical course are managed with pancreatic rest through nil per oral;while the use of specific nutritional intervention is an exception.Therefore,mild AP has been the most investigated form of AP and researchers have tried different kind of meals to offer calories and reduce costs by shortening hospitalization time.Usually in mild AP,the oral refeeding is introduced between the first 3 d and 7 d after hospitalization but,the type of diet and patients’tolerance have been scrutinized in detail with mixed results.Although 20%to 25%have pain recurrence requiring nutritional support and greater time of hospitalization,most patients seem to tolerate oral refeeding well.We propose analyzing the most recent investigations of this matter and their conclusions to develop a better understanding of the management of AP. | Júlio Maria F Chebli Pedro D Gaburri Liliana A Chebli | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 4 | Effects of feeding yeast(Saccharomyces cerevisiae), organic selenium and chromium mixed on growth performance and carcass traits of hair lambs显示文摘Yeasts and organic minerals are used in diets to improve health, productive performance and some carcass characteristics of ruminants and non-ruminants. Thirty-two lambs(Pelibuey×Katahdin; BW=(30.55±1.67) kg; n=8) were used in a 56-d feeding experiment to study the effects of different levels of live yeast(Saccharomyces cerevisiae; yeast), selenium(Se) and chromium(Cr) mixed(Se-Cr), and a mixture of yeast-Se-Cr on growth performance and carcass traits. Animals were stratified by body weight(BW) and randomly assigned to one of four treatments: 1) control group(0.0 g kg–1 yeast); 2) yeast(1.50 g kg–1 dry matter intake(DMI) d–1); 3) Se-Cr premix(1.5 mg kg–1 DMI d–1 for each mineral); and 4) yeast-Se-Cr mixture. There were no treatment effects on final BW; whereas lambs fed Se-Cr or yeast-Se-Cr had higher(P<0.05) DMI than animals supplemented with only yeast. Average daily gain(ADG), gain:feed ratio, chop area, dorsal fat and carcass yield were similar(P>0.05) among treatment groups. In conclusion, supplementation with yeast, Se-Cr mixed or yeast-Se-Cr did not improve ADG, final BW, back fat content and carcass yield of growing of Pelibuey×Katahdin lambs. Supplementation with Se-Cr and yeast-Se-Cr increased DMI, and approximately 250 g ADG animal–1 d–1 was produced with no negative effects on growth and health of the animals. | Pedro A Hernández-García Alejandro Lara-Bueno Germán D Mendoza-Martínez José R Bárcena-Gama Fernando X Plata-Pérez Rufino López-Ordaz José A Martínez-García | 2015 | Journal of Integrative Agriculture2015，14，3： | 2 |
| 5 | Subclinical hyperthyroidism in patients with type 2 diabetes显示文摘 | Juan Díez Pedro Iglesias | 2012 | Endocrine2012，，1： | 2 |
| 6 | In vitro evalua- tion of ureteral perforation forces 显示文摘 | Pedro R Hendlin K Weiland D | 2007 | Urology2007，70，： | 1 |
| 7 | Gpu based real- lime inslrument tracking with three-dimensional ultrasound显示文摘 | Novotny P M Stoll J A Pedro E Nido J D | 2007 | Medical Image Analysis2007，11，5： | 1 |
| 8 | Evaluation of the poten-tial emissions reductions from the use of CHP systems indifferent commercial buildings显示文摘 | Mago Pedro J Smith Amanda D | 2012 | Building and Environ-ment2012，53，： | 1 |
| 9 | A study on experimental benchmarks and simulation results in sheet metal forming显示文摘 | Abel D S Pedro T | | 0，，： | 1 |
| 10 | Formal concept analysis as a support technique for CBR显示文摘 | Belen D A Pedro A | 2001 | Knowledge-based Systems2001，14，3： | 1 |
| 11 | Determination of shelf-life of homogenized apple-based beikost storage at different temperatures using Weibull hazard model显示文摘 | Palazón M A Pérez-Conesa D Pedro A | 2009 | LWT-Food Science and Technology2009，42，1： | 1 |
| 12 | Stem xylem features in three Quercus (Fagaceae)specis along a climatic gradient in NE Spain 显示文摘 | Pedro Villar - Salvador Pilaf Castro - Díez Carmen Pérez -Rontomé | 1997 | Trees1997，12，2： | 1 |
| 13 | Purification,structure and immunobiological activity of an arabinan-rich pectic polysaccharide from the cell walls of Prunus dulcis seeds显示文摘 | Fernando D Pedro M Vera C | 2004 | Carbohydr Res2004，339，15： | 1 |
| 14 | DC voltage control and stability analysis of PWM voltage type prversible rectifiers显示文摘 | Pedro Verdelho Marques G D | 1998 | IEEE Trans on IE1998，45，2： | 1 |
| 15 | Urinary CNN2(CTGF) as a possible predictor of diabetic nephropathy : preliminary report显示文摘 | Bruce LR Pedro C Mapk D | 2003 | Kidney Int2003，64，4： | 1 |
| 16 | Spatial modeling: A comprehensive framework for principal coordinate anal- ysis of neighbor matrices (PCNM)显示文摘 | Stephane D Legendre P Pedro R | 2006 | Ecological Modeling2006，196，： | 1 |
| 17 | Urinary CTGF as a possible predictor of diabetic nephropathy显示文摘 | Bruce LR Pedro C Mapk D | 2003 | Am Soc Nephrol2003，64，5： | 1 |
| 18 | Effect of human chorionic gonadctrophin supplementation during different culture periods on in viro maturation of canine oocytes显示文摘 | Monica D R Johanna D L Pedro M | 2005 | Theriogenology2005，64，： | 1 |
| 19 | Clone precocity and the use of Helianthus tuberosus I: stems for bioethanol 显示文摘 | Maria D C Pedro A Marina S | 2006 | In dustrial Crops and Products2006，24，： | 1 |
| 20 | Estimation of the rate of slowly biodegradable COD (SBCOD) hydrolysis under anaerobic, anoxic and aerobic conditions by experiments using starch as model substrate 显示文摘 | Mino T Pedro D C S Matsuo T | 1995 | Water Sci Technol1995，31，2： | 1 |
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