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| 1 | Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis显示文摘CREB 有约束力的蛋白质(CBP ) 和它的相当或相同事物 p300 是涉及细胞的活动的一个宽数组的各种各样的顺序特定的抄写因素的 transcriptionalco 使活跃之物,例如脱氧核糖核酸修理,房间生长,区别和 apoptosis。Severalstudies 建议了 CBP 和 p300 可能被看作瘤压制 ors,与他们是的突出的角色响应各种各样的刺激的不同基因表示模式的跨 coupling。他们主要经由乙酰化施加行动嘘和另外的规章的蛋白质(例如 p53 ) 。在 CBP/p300 功能的主要悖论是他们似乎能够贡献各种各样的反对细胞的进程。呼吸上皮 tumorigenesis 代表一个范围的多步累积的一个复杂过程基因并且 epigenetic 错误。通过激活和压抑的建筑群的交替的形成的 Transcriptionmodulation 是这些精神错乱的最终的收敛点,并且 CBP/p300 在这相互影响代表关键参加者。因此,他们的分子的行动和相互作用的照明能在呼吸上皮 carcinogenesis 为药理学干预揭示新潜在的目标。 | Michalis V Karamouzis Panagiotis A Konstantinopoulos Athanasios G Papavassiliou | 2007 | Cell Research2007，17，4： | 5 |
| 2 | 在线压缩感知方法及其在漏磁检测中的应用显示文摘以长距离油管的漏磁检测系统为研究对象,研究了漏磁检测数据的在线压缩算法。针对嵌入式在线工作环境下,传统的数据压缩方法难以应用的问题,引入压缩感知(CS)理论,提出了漏磁检测数据在线CS压缩方法。确定了小波基作为漏磁信号的最佳稀疏表示基,并推导了小波稀疏基矩阵的数学表达公式;提出Welch界和PRP共轭梯度算法的测量矩阵优化算法;提出了漏磁检测数据的重要数据段筛选方法,极大地减少了数据存储量。仿真试验证明了所提出在线压缩算法极大地减少了在线环境压缩编码的运算复杂度,具有简单迅速、压缩比高、重构精度高等优点,符合漏磁检测数据在线压缩的实际要求。 | 张兰勇 陈辉煌 刘胜 Christos Papavassiliou | 2017 | 仪器仪表学报2017，38，7： | 4 |
| 3 | Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal diseases,with an average 5-year survival rate of less than 10%.Unfortunately,the majority of patients have unresectable,locally advanced,or metastatic disease at the time of diagnosis.Moreover,traditional treatments such as chemotherapy,surgery,and radiation have not been shown to significantly improve survival.Recently,there has been a swift increase in cancer treatments that incorporate immunotherapybased strategies to target all the stepwise events required for tumor initiation and progression.The results in melanoma,non-small-cell lung cancer and renal cell carcinoma are very encouraging.Unfortunately,the application of checkpoint inhibitors,including anti-CTLA4,anti-PD-1,and anti-PD-L1 antibodies,in pancreatic cancer has been disappointing.Many studies have revealed that the PDAC microenvironment supports tumor growth,promotes metastasis and consists of a physical barrier to drug delivery.Combination therapies hold great promise for enhancing immune responses to achieve a better therapeutic effect.In this review,we provide an outline of why pancreatic cancer is so lethal and of the treatment hurdles that exist.Particular emphasis is given to the role of the tumor microenvironment,and some of the latest and most promising studies on immunotherapy in PDAC are also presented. | Panagiotis Sarantis Evangelos Koustas Adriana Papadimitropoulou Athanasios G Papavassiliou Michalis V Karamouzis | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 4 |
| 4 | Upgraded role of autophagy in colorectal carcinomas显示文摘Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients. | Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis V Karamouzis | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 3 |
| 5 | Malware-Propagative Mobile Ad Hoc Networks:Asymptotic Behavior Analysis显示文摘在这篇论文,在合法节点是容易的宣传他们从一个攻击者或他们的已经感染的邻居收到的感染的地方,在特定的网络上传播恶意的软件被分析。就 Susceptible-Infected-Susceptible (SIS ) 节点感染范例而言,我们建议一个概率模型,根据闭合排队网络的理论,当由恶意的节点攻击了时,那瞄准描述系统的聚集的行为。因为它的性质,模型也能更有效地处理攻击者的随机的行为和无线环境的固有的概率的性质。建议模型能精确地描述 malware-propagative 的 asymptotic 大规模特定的联网环境。用闭合排队网络的 Norton 等价物,我们为它的稳态行为获得分析结果,它接着被用于识别影响网络的操作的批评参数。通过当模特儿和模拟,当多重攻击者是在场的时,最后,某另外的数值结果关于系统的行为被获得,并且考虑时间依赖者进化和攻击的影响。 | Vasileios Karyotis Anastasios Kakalis Symeon Papavassiliou | 2008 | Journal of Computer Science & Technology2008，23，3： | 3 |
| 6 | A comprehensive resource management framework for next generation wireless networks显示文摘 | Ye Jian Hou Jiongkuan Papavassiliou S | 2002 | IEEE Transactions on Mobile Computing2002，1，4： | 2 |
| 7 | Standardization versus adaptation of international advertising strategies: Towards a framework显示文摘 | Nikolaos Papavassiliou Vlasis Stathakopoulos | 1997 | European Journal of Marketing1997，，7： | 2 |
| 8 | Optical properties of small inorganic and organic metal particles显示文摘 | PAPAVASSILIOU G C | 1980 | Prog Solid State Chem1980，，12： | 1 |
| 9 | The potential of proteasome inhibition in the treatment of colon cancer显示文摘 | Konstantinopoulos PA Papavassiliou AG | 2006 | Expert Opin Investig Drugs2006，15，9： | 1 |
| 10 | Correlates between hyperinsulinism and hyperandrogenemia? 显示文摘 | Kassi EN Diamanti-Kandarakis E Papavassiliou AG | 2008 | Fertil Steri12008，89，4： | 1 |
| 11 | Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance显示文摘 | N. Kapranos A. Kominea P. Konstantinopoulos S. Savva S. Artelaris G. Vandoros G. Sotiropoulou-Bonikou A. Papavassiliou | 2002 | Journal of Cancer Research and Clinical Oncology2002，，8： | 1 |
| 12 | Emer- ging role of advanced glyeation-end products (AGEs) in the pathobiology of eye diseases 显示文摘 | Kandarakis SA Piperi C Topouzis F Papavassiliou AG | 2014 | Prog Retin Eye Res2014，42，1： | 1 |
| 13 | Network intrusion and fault detection:A statistical anomaly approach显示文摘 | Manikopoulos C Papavassiliou S | 2002 | IEEE Communications Magazine2002，，： | 1 |
| 14 | Online measurement of fiber diameter and temperature in the melt-spinning and melt-blowing processes显示文摘 | Maria Vishnu T Shambaugh Robert L Papavassiliou Dimitros V | 2009 | Industrial & Engineering Chemistry Re- search2009，48，18： | 1 |
| 15 | Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors显示文摘 | Karamouzis MV Konstantinopoulos PA Papavassiliou AG | 2009 | Lancet Oncol2009，10，7： | 1 |
| 16 | Modifying air fields to improve melt blowing显示文摘 | Shambaugh B R Papavassiliou D V Shambaugh R L | 2012 | Industrial & Engineering Chemistry Research2012，51，8： | 1 |
| 17 | Prostaglind E2 down-regulates the expression of HLA-DR antigen in human colon adcarcinoma cell lines显示文摘 | Arvind P Papavassiliou ED Tsioulias GT | 1995 | Biochemistry1995，34，16： | 1 |
| 18 | Molecular mechanisms of insulin resistance in polycystic ovary syndrome显示文摘 | Diamanti-Kandarakis E Papavassiliou AG | 2006 | Trends Mol Med2006，12，： | 1 |
| 19 | Diagnosis of ovine enzootic abortion, using a competitive ELISA based on monoclonal antibodies against variable segments 1 and 2 of the major outer membrane protein of Chlamydia psittaci serotype 1 显示文摘 | Salti-Montesanto V Tsoli E Papavassiliou P | 1997 | Am J Vet Res1997，58，3： | 1 |
| 20 | Handwritten document image segmentation into text lines andwords 显示文摘 | Papavassiliou V Stafylakis T Katsouros V | 2010 | Pattern Recognition2010，43，： | 1 |
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