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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Multiparticle Production on Hydrogen, Argon and Xenon Targets in a Streamer Chamber by 200-GeV/c Proton and Antiproton Beams 显示文摘 | Marzo C D Palma M D Distante A | 1982 | Phys Rev D1982，25，： | 2 |
| 4 | Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions显示文摘 | Silvina G. Castro Sergio F. Sanchez Bruni Lucí a P. Urbizu Alejandra Confalonieri Laura Ceballos Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2013 | Pharmaceutical Development and Technology2013，，2： | 2 |
| 5 | Localization of manganese-superoxide dismutase in peroxisomes isolated from Pisum sativum L显示文摘 | Sandalio L M Palma J M del Río L A | 1987 | Plant Science1987，51，： | 1 |
| 6 | Inhibition of Urokinase-Type Plasminogen Activator or Matrix Metalloproteinases Prevents Cardiac Injury and Dysfunction During Viral Myocarditis显示文摘 | Pauschinger M De Palma A | 2006 | Circulation2006，114，： | 1 |
| 7 | Trace elements, anxiety andimmune parameters in patients affected by cancer 显示文摘 | Bargellini A piccinini L De Palma M | 2003 | J Trace Elem MedBioll2003，17，1： | 1 |
| 8 | Late - onset noninfectiouspulmonary complications after allogeneic bone marrow transplanta- tion 显示文摘 | Palmas A Tefferi A Myers JL | 1998 | Br J Haemotol1998，100，4： | 1 |
| 9 | A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bio- analysis by means of HybridSPE 显示文摘 | PUCCI V DI PALMA S ALFIERI A | 2009 | J Pharm Biomed Anal2009，50，5： | 1 |
| 10 | Paradoxical sleep deprivation increases plasma endothelin levels 显示文摘 | Palma B D Gabriel A Bignotto M | 2002 | Braz J Med Biol Res2002，35，1： | 1 |
| 11 | The possible role of ChemR23/Chemerin axisin the recruitment of dendritic cells in lupus nephritis显示文摘 | DE PALMA G CASTELLANO G DEL PRETE A | 2011 | Kidney Int2011，79，11： | 1 |
| 12 | Three-dimensional electrodes for the electrochemical combustion of organic pollutants显示文摘 | POLCARO A M PALMAS S RENOLDI F | 2000 | Electrochim Acta2000，46，23： | 1 |
| 13 | Environ-mental stresses affect tomato microsomal membrane function differently than natural ripening and senes-cence显示文摘 | Marangoni A G Stanley D W | 1995 | Postharvest Biol Technol1995，6，： | 1 |
| 14 | Clinical outcome of closed isolated subtalar dislocations显示文摘 | de Palma L Santucci A Marinelli M | 2008 | Arch Orthop Trauma Surg2008，128，6： | 1 |
| 15 | Ultrasound-assisted extraction of soy isoflavones显示文摘 | Rostagno M A Palma M B Carmelo G | 2003 | Journal of Chromatography A2003，1012，2： | 1 |
| 16 | Variable Willingness to Pay for Network Externalities with Strategic Standardization Decisions 显示文摘 | De Palma A Leruth L | 1996 | European Journal of Political Economy1996，12，： | 1 |
| 17 | Iron and Cobalt Complexes of 4 - Alkyl - 2, 6 - Diiminopyri- dine Ligands: Synthesis and Ethylene Polymerization Ca- talysis 显示文摘 | CAOMPORA P J NAZ A M PALMA R P | 2008 | European Journal of Inorganic Chemistry2008，，11： | 1 |
| 18 | Anatomy of the Lisfranc joint complex 显示文摘 | Palma L Santucci A Sabetta SP | 1997 | Foot Ankle Int1997，18，6： | 1 |
| 19 | Antioxidatire enzymes in cultivars of pepper plants with different sensitivity to cadmium显示文摘 | LE(O)N A M PALMA J M CORPAS F J | | 0，，10： | 1 |
| 20 | Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate显示文摘 | PALMIERI L LASORSA F M PALMA A D | 1997 | FEBS Lett1997，417，： | 1 |
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