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| 1 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 2 | Transportation Characteristics Change under Rapid Urban Expansion:A Case Study of Shanghai显示文摘This paper focuses on the economic development and urban morphology as well as its impact on the transportation system during the urban expansion of Shanghai in the last more than 20 years(1986-2008).Based on data from 3 comprehensive transport surveys of Shanghai since 1986,the changes in residential trip demand,vehicle use,and the spatial distribution of trips were studied to understand the demands on the transportation system.The factors contributing to those changes in transportation demand were discussed,by which the conclusions were arrived:1) economic development promotes population growth and stimulates residential trip demand greatly;2) unsynchronized migration of population and job from central district to periphery district of Shanghai make trips and congestion diffuse in the same way;and 3) urban sprawl from a city center encourages the single-occupant vehicle mode,which imposes greater pressure on the roadway system.It is concluded that urban development should coordinate with the transportation system planning and expansion. | LI Ye YE Jianhong CHEN Xiaohong Mohamed A ABDEL-ATY P E CEN Min | 2010 | Chinese Geographical Science2010，20，6： | 2 |
| 3 | Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus显示文摘To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK- mutant were sequenced. Analysis of the tk gene sequence of TK mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All | Pan, ZS Zhang, CY Ding, JH Min, P | 2001 | Chinese Science Bulletin2001，46，23： | 2 |
| 4 | MAAN:A Multi-attribute Addressable Network for Grid Information Services显示文摘 | Cai Min Frank M Szekely P | 2004 | Journal of Grid Computing2004，2，1： | 1 |
| 5 | Liver transplantation:changing goals in immunosuppression显示文摘 | McMaster P Gunson B Min X | 1998 | Transplant Proc1998，30，5： | 1 |
| 6 | CT evaluation of spontaneously ruptured renal angiomyolipomas with massive hemorrhage spreading into multi-retroperitoneal fascia and fascial spaces显示文摘 | Lu C Y Min P Q Wu B | 2012 | Acta Radiol Short Rep2012，1，4： | 1 |
| 7 | Implantable silk composite microneedles for programmable vaccine release ki- netics and enhanced immunogenicity in transcutaneous immu- nization显示文摘 | DEMUTH P C MIN Y IRVINE D J | 2014 | AdvHealthcMater2014，3，1： | 1 |
| 8 | Reduction of machining errors of a three-axis machine tool by on-machine measurement and error compensation system 显示文摘 | Choi J P Min B K Lee S J | 2004 | Journal of Materials Processing Technology2004，155，： | 1 |
| 9 | A soil-water hysteresis model for unsaturated sands based on fuzzy set plasticity theory 显示文摘 | Min T K Huy P T | 2010 | KSCE Journal of Civil Engineering2010，14，2： | 1 |
| 10 | Antimicrobial fabrication of cotton fabric and leather rising 显示文摘 | Velmurugan P Min Cho Sang - Myeong Lee | 2014 | Car- bohydrate Polymers2014，106，15： | 1 |
| 11 | Green Purchasing Strategies: Trends and Implications显示文摘 | Min H and Galle P | 1997 | Journal of Supply Chain Management1997，33，3： | 1 |
| 12 | Cavernous transformation of the portal vein secondary to tumor thrombosis of hepatocellular car- cinoma : spiral CT visualization of the collateral vessels显示文摘 | Song B Min P Oudkerk M | 2000 | Abdom Imaging2000，25，4： | 1 |
| 13 | Curve-skeleton properties,applications,and algorithms显示文摘 | Cornea N D Silver D Min P | 2007 | IEEE Transactions onVisualization and Computer Graphics2007，13，3： | 1 |
| 14 | The glioma-associated oncogene homolog 1 promotes epithelial-mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail显示文摘 | Min S Xiaoyan X Fanghui P | 2013 | Cancer Gene Ther2013，20，7： | 1 |
| 15 | Measurement of oxidized glutathione by enzymatic recycling coupled to bioluminescent detection显示文摘 | Mourad T Min K L Steghens J P | 2000 | Analytical Biochenistry2000，283，2： | 1 |
| 16 | Super-resolution image reconstruction: a technical overview 显示文摘 | Sung C P Min K P Moon G K | 2003 | IEEE Signal Processing Magazine2003，20，3： | 1 |
| 17 | Isolation and genetic characterization of H5N2 influenza viruses from pigs in korea显示文摘 | Jun H L Philippe N Q P Min Suk S | 2009 | Journal of Virology2009，83，9： | 1 |
| 18 | The Princeton shape benchmark显示文摘 | SHILANE P MIN P KAZHDAN M | 2004 | Proceedings of Shape Modeling International2004，，： | 1 |
| 19 | On the ferritc and binate trans- formation in isothermally deformed 22MnB5 steels显示文摘 | Min J Y Lin J P Min Y A | 2012 | Materials Science & Engineering A2012，550，： | 1 |
| 20 | An appraisal of a col- umn- generation -based algorithm for centralized train - conflict resolution on a metropolitan railway network 显示文摘 | Min Y H Park M J Hong S P | 2011 | Transportation Research Part B2011，45，2： | 1 |
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