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| 1 | The Quaternary Structure of NADPH Thioredoxin Reductase C Is Redox-Sensitive显示文摘NADPH thioredoxin reductase C (NTRC ) 是能结合 NADPH thioredoxin reductase (NTR ) 和 thioredoxin (TRX ) 的叶绿体酶为 2-Cys peroxiredoxin (2-Cys PRX ) 的有效减小的活动。因为 NADPH 能在黑暗期间在叶绿体被生产, NTRC 在夜里期间为植物过氧化物 detoxification 起一个关键作用。这里, NTRC 的第四级的结构高度依赖于它的氧化还原作用地位,这被显示出。在 vitro,大多数酶采用了一个 oligomeric 状态在在 NADPH, NADH,或 DTT 的增加之上的 dimers 的那 disaggregated。胶化过滤和从 Arabidopsis 叶绿体基质的蛋白质摘录的西方的污点分析证明本国的 NTRC 形成总数,它对 NADPH 和 DTT 敏感,建议聚集状态可能是在 vivo 的 NTRC 活动的一个重要方面。而且,酶在在 Arabidopsis 叶绿体的簇是局部性的。NTRC 三倍、双的异种, A164G-V182E-R183F 和 A164G-R183F,代替 NADPH 有约束力的地点的关键残余,显示出减少的活动,但是仍然能随中间人形式的增加不过使聚合成二聚物。把结果基于这些,我们建议 NTRC 的催化地活跃的形式更暗淡,形成它被 NADPH 导致。 | Juan Manuel Pérez-Ruiz Maricruz Gonzalez Maria Cristina Spinola Luisa Maria Sandalio Francisco Javier Cejudo | 2009 | Molecular Plant2009，2，3： | 3 |
| 2 | Erosion problem in tool steel using cold box core-making process显示文摘This paper presents the erosion results of the AISI H13 steel impinged by resin-bonded silica sand, using a testing rig that closely simulates the real blowing conditions during industrial core-making. Steel specimens were heat treated to obtain hardness of 294, 445 and 595 HV200 (29, 45 and 55 HRC). Erosion tests were carried out at impingement angles from 20° to 90° and air drag pressures of 1.38, 2.07 and 2.76 bar (20, 30 and 40 psi). The main results are summarized as follows:(i) The harder material, the lower erosion;(ii) the maximum erosion rate is at 30°;(iii) Little difference in erosion rate at impact angle of 60° and 90° for a constant pressure tested regardless of the hardness level;(iv) As the pressure increases, so does the erosion rate, being more sensitive for low impact angles. Finally, a differential form of the general erosion equation is applied on a practical core-making case to evaluate the erosion rate of the H13 steel at 30° and 90° impingement angles. | Eduardo Rodríguez Alberto Pérez Rafael David Mercado-Solis Velasco-Téllez Abraham Omar Jimenez Martin Flores Marco Aurelio Gonzalez Jesus Ibarra | 2019 | China Foundry2019，16，3： | 2 |
| 3 | Impact of changes in the treatment of nasopharyngeal carcinoma: an experience of 30 years 显示文摘 | Santos JA Gonzalez C Cuesta P | 1995 | Radiotherapy and Oncology1995，36，2： | 2 |
| 4 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 5 | Effects of parenteral nutrition suplemented with glutamine or glutamine dipeptides on liver antioxidant and detoxication systems in rats显示文摘 | Matilla B Ortiz J Gonzalez P | 2000 | Nutrition2000，16，2： | 1 |
| 6 | improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin 显示文摘 | Bolla M Gonzalez D Warde P | 1997 | N EngtJ Med1997，337，5： | 1 |
| 7 | The Intestinal Anti-Inflammatory Agent Glycomacropeptide Has Immunomodulatory Actions on Rat Splenocytes 显示文摘 | REQUENA P GONZALEZ R POSADAS R L | 2010 | Biochemical Pharmacology2010，，79： | 1 |
| 8 | Incidence and c]inical effects of intra--abdominal hypertension in critically ill patients显示文摘 | ViDL MG P uiz Weisser J Gonzalez F | 2008 | Critical care medicine2008，56，6： | 1 |
| 9 | Behavior of brain perfusion with SPECT tomography 99mTc ethylene dicysteine (ECD) in alcohol and cocaine dependents during abstinence显示文摘 | Pallavicini Gonzalez J Massardo Vega T Arancibia Soto P | 2002 | Rev Esp Med Nucl2002，21，6： | 1 |
| 10 | Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus :efficacy and risk of ftmgal over - infection显示文摘 | Gonzalez - Garcia A Diniz - Freitas M Gandara - Vila P | 2006 | Oral Dis2006，12，6： | 1 |
| 11 | Differential ex-pression of isoflavone biosynthetic genes in soybean during water deficits显示文摘 | GONZALEZ J G GUTTIKONDA S K TRAN L S P | 2010 | Plant Cell Physiol2010，51，6： | 1 |
| 12 | Solid-phase extrac-tion and determination of trace aroma and flavor components in cider by GC-MS 显示文摘 | Mangas J J Gonzalez M P Rodriguez R | 1996 | Chromatogra phia1996，42，12： | 1 |
| 13 | Safety,tolerbility,and immunogenicity of a two-dose regimen of high-titer varicella vaccine in subjects≥13 years of age显示文摘 | DIAZ C DENTICO P GONZALEZ R | 2006 | Vaccine2006，24，4748： | 1 |
| 14 | Summary of the consensus document:“Clinical practice guide forthe management of low cardiac output syndrome in the postoperativeperiod of heart surgery”显示文摘 | Pérez Vela JL Martín Benitez JC Carrasco Gonzalez M | 2012 | Medicina Intensiva (EnglishEdition)2012，36，4： | 1 |
| 15 | Third-generation cephalosporin resistance in shigella sonnie显示文摘 | Radice M Gonzalez C Power P | 2001 | Argentina Emerg Infect Dis2001，7，： | 1 |
| 16 | Dosimetric characterization of a new preparation of BaSOa activated by Eu ions显示文摘 | GONZALEZ P R FURETTA C CALVO B E GASO M I CRUZ-ZARAGOZA E | 2007 | Nucl Instrum Meth B2007，260，： | 1 |
| 17 | Anaphylaxis to proton pump inhibitors显示文摘 | Soriano V Lopez P | 2002 | Allergol Immunopathol2002，30，6： | 1 |
| 18 | Leptin upregulates beta-3-integfin expression and interleukin-1 Beta,upregulates ieptin and leptin receptor expression in human endometrial cell cultures显示文摘 | Gonzalez RR Leavis P | 2001 | Endocrinoligy2001，16，1： | 1 |
| 19 | A multi - criteria GIS based procedure to solve a network compet- itive location problem 显示文摘 | Suarez - Vega R Santos - Penate D R Dorta - Gonzalez P | 2011 | Applied Geography2011，，1： | 1 |
| 20 | Differential expression of Wnts after spinal cord contusion injury in adult rats显示文摘 | Fernandez-Martos CM Gonzhiez-Femandez C Gonzalez P | 2011 | PLoS One2011，6，27： | 1 |
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