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| 1 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Acid-base interfacial interactions in aqueous media显示文摘 | Van Oss C | 1993 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1993，78，1： | 1 |
| 3 | Seaglider: a long-range autonomous underwater vehicle for oceanographic research 显示文摘 | ERIKSEN C C OSSE TJ LIGHT RD | 2001 | IEEE Journal of Oceanic Engineering2001，126，4： | 1 |
| 4 | Monopolar surfaces显示文摘 | Van Oss CJ Chaudhury MK Good RJ | 1987 | Advance in Collid and Interface Science1987，28，1： | 1 |
| 5 | Vitamin D deficiency is the cause of common obesity显示文摘 | OSS YJ | 2009 | Med Hypotheses2009，72，3： | 1 |
| 6 | Fish larvae,de-velopment,allometric growth,and the aquatic environ-ment 显示文摘 | Osse J W M van den Boogart J G M | 1995 | ICES Marine Science Symposia1995，201，： | 1 |
| 7 | Spatial disaggregation of traffic emission inventories in large cities using simplified top-down methods 显示文摘 | SAIDE P ZAH R OSSES M | 2009 | Atmospheric Environment2009，43，32： | 1 |
| 8 | Larval growth patterns in Cyprinus carpio and Clarias gariepinus with attention to finfold 显示文摘 | van Snik G M J van den Boogaart J G M Osse J W M | 1997 | Journal of Fish Biology1997，50，13： | 1 |
| 9 | The surface the-rmodynamic properties of talc treated with octadecy lamine显示文摘 | Li Z Giese R F Oss V C J | 1993 | Colloid and Interface Sci1993，156，： | 1 |
| 10 | Oxidation of grape juice phenolic compounds in model solutions显示文摘 | CHEYNIER V OSSE C RIGAUD J | 1988 | J Food Sci1988，53，17： | 1 |
| 11 | Cement Manufacture and the Environment:Environmental Challenges and Opportunities显示文摘 | Van Oss H G Padovani A C | 2003 | Journal of Industrial Ecology2003，7，1： | 1 |
| 12 | Larval growth patterns in Cyprinus carpio and Clarias garie-pinus with attention to the finfold 显示文摘 | Snik G M J Boogaart J G M Osse J W M | 1997 | Journal of Fish Biology1997，50，13： | 1 |
| 13 | Assessment of the need for palliative care as perceived by individual cancer patients and their families:A review of instruments for improving patient participation in palliative care显示文摘 | Osse BH Vernooi j-Dassen MJ de Vree BP | 2000 | Cancer2000，88，4： | 1 |
| 14 | Seaglider: A long-range autonomous underwater vehicle for oceanographic research显示文摘 | Eriksen C C Osse T J Light R D | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 15 | Phonomicrosurgery 1I : surgical techniques 显示文摘 | Garrett C G Oss~off R H | 2000 | Otolmyngol Clin North Am2000，33，5： | 1 |
| 16 | Additive and Nonadditive Surface Tension Components and The lnerpretation of Contact Angles显示文摘 | Van Oss CCJ Good R J Chaudhury M K | 1988 | Langmuir1988，，4： | 1 |
| 17 | Bleaching of eucalyptus kraft pulp with commercial xylanases显示文摘 | Vicuna R Escobar F Osses M | 1997 | Biotechnol Lett1997，19，： | 1 |
| 18 | Seaglider: A long-range autonomous underwater vehicle for oceanographic research显示文摘 | Eriksen C C Osse T J Light R D | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 19 | Dnubh'-hit B-cell lympholnas with bel6 and mye translocatinns are aggTessive, fi+equcntly extranodal lymphomas distinct from twl2 double-hit B- cell lymphomas 显示文摘 | Pillai RK Salhanoori M Van Oss SB | 2013 | Am J Surg Pathol2013，37，3： | 1 |
| 20 | Mechanism of partition in aqueous media显示文摘 | van Oss C J Chaudhury M K Good R J | 1987 | Separation Science and Technology1987，22，6： | 1 |
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