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| 1 | 叶酸与甲酰四氢叶酸用于减少甲氨蝶呤治疗副作用(摘要)显示文摘1 背景 甲氨蝶呤用于治疗许多风湿病,其短期疗效已被证实。但毒性使不少患者不能从中受益,其中叶酸缺乏可增加其毒性。类风湿关节炎患者常有叶酸缺乏,经甲氨蝶呤治疗后叶酸储备就进一步减少。甲氨蝶呤的胃肠道和血液学副作用都与叶酸缺乏有关,可以预见,叶酸补充疗法将有助改善低剂量甲氨蝶呤治疗的副作用。对此,已有不少试验开展,并提出不同的副作用减少率。 | Ortiz Z SheaB Suarez Almazor M Moher D Wells G Tugwell P 姚如愚 | 2001 | 循证医学2001，1，1： | 4 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging显示文摘Aging is a global phenomenon and a complex biological process of all living beings that introduces various changes.During this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic spines.Likewise,it presents a great reduction in volume resulting from the contraction of the gray matter.Consequently,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older people.As a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative diseases.It is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo models.This review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and rapamycin.Most of these molecules have been evaluated by our research group.Studies suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative diseases.Hence,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic. | Itzel Ortiz Flores Samuel Treviño Alfonso Díaz | 2023 | Neural Regeneration Research2023，18，1： | 2 |
| 4 | Climate change: Can wheat beat the heat?显示文摘 | Ortiz R Sayre K D Govaerts B | 2008 | Agriculture Ecosystems & Environment2008，126，12： | 1 |
| 5 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 6 | Strain-induced po- larization rotation in epitaxial (001) BiFeOa thin films 显示文摘 | Jang H W Back S H Ortiz D | 2008 | PhysRevLett2008，101，10： | 1 |
| 7 | Chronic alcohol-induced liver disease inhibits dendritic cell function显示文摘 | Feng D Eken A Ortiz V | 2011 | Liver Int2011，31，7： | 1 |
| 8 | Optical performance of monofocal and multifocal intraocular lenses in the human eye显示文摘 | Ortiz D Alio JL Bernabeu G | 2008 | J Cataract Refract Surg2008，34，5： | 1 |
| 9 | Generalized Jordan-Wigner Trans- formations 显示文摘 | Batista C D Ortiz G | 2001 | Phys Rev Lett2001，81，6： | 1 |
| 10 | Concentration of bovine serum albumin aqueous solution by memabrane distillation 显示文摘 | Zamte D Ortiz J M Rincon C | 1998 | Sep Sci Technol1998，33，3： | 1 |
| 11 | Modeling and simulation of high-speed machining显示文摘 | MARUSICH T D ORTIZ M | 1995 | International Journal for Numerical Methods in Engineering1995，38，21： | 1 |
| 12 | Modeling and simulation of highspeed machining显示文摘 | Marusieh T D Ortiz M | 1995 | Int J Numer Methods Engrg1995，38，： | 1 |
| 13 | Apple juice prevents oxidative stress induced by amyloid-beta in culture显示文摘 | ORTIZ D SHEA T B | 2004 | Journal of Alzheimer'' s Disease2004，6，1： | 1 |
| 14 | Developing a mini core of peanut for utilization of genetic resources显示文摘 | Upadhyaya H D Bramel P J Ortiz R | 2002 | Crop Science2002，42，6： | 1 |
| 15 | A new progressive iterative algorithm for multiple structure alignment 显示文摘 | LUPYAN D LEO-MACIAS A ORTIZ A R | 2005 | Bioinformatics2005，21，15： | 1 |
| 16 | Impact of positive goal and resource interdependence on achievement,interaction,and atti-tudes显示文摘 | Johnson D W Johnson R Ortiz A | | 0，，04： | 1 |
| 17 | A mini core subset for capturing diversity and promoting utilization of chickpea genetic resources in crop improvement显示文摘 | Upadhyaya H D Ortiz R | 2001 | Theor Appl Genet2001，102，8： | 1 |
| 18 | A reconstruction of late Pleistocene relative sea level in the south Bohai Sea,China,based on sediment grain-size analysis显示文摘 | YI Liang YU Hong-jun ORTIZ J D | 2012 | Sedimentary Geology2012，281，： | 1 |
| 19 | Corneal biomechanical properties in normal, post-laser in situ keratomileusis and keratoconic eyes 显示文摘 | Ortiz D Pifiero D Shabayek MH | 2007 | J Cataract Refract Surg2007，8，： | 1 |
| 20 | Rabs and their effectors: achieving specificity in membrane traffic显示文摘 | Grosshans B L Ortiz D Novick P | 2006 | Proc Natl Acad Sci U S A2006，103，11： | 1 |
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