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| 1 | Transient elastography(Fibro Scan~?) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease- Where do we stand?显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common cause of chronic liver disease worldwide. Currently, the routinely used modalities are unable to adequately determine the levels of steatosis and fibrosis(laboratory tests and ultrasonography) or cannot be applied as a screening procedure(liver biopsy). Among the non-invasive tests, transient elastography(Fibro Scan?, TE) with controlled attenuation parameter(CAP) has demonstrated good accuracy in quantifying the levels of liver steatosis and fibrosis in patients with NAFLD, the factors associated with the diagnosis and NAFLD progression. The method is fast, reliable and reproducible, with good intra- and interobserver levels of agreement, thus allowing for population-wide screening and disease follow-up. The initial inability of the procedure to accurately determine fibrosis and steatosis in obese patients has been addressed with the development of the obese-specific XL probe. TE with CAP is a viable alternative to ultrasonography, both as an initial assessment and during follow-up of patients with NAFLD. Its ability to exclude patients with advanced fibrosis may be used to identify low-risk NAFLD patients in whom liver biopsy is not needed, therefore reducing the risk of complications and the financial costs. | Ivana Mikolasevic Lidija Orlic Neven Franjic Goran Hauser Davor Stimac Sandra Milic | 2016 | World Journal of Gastroenterology2016，22，32： | 33 |
| 2 | Nonalcoholic fatty liver disease-A multisystem disease?显示文摘Non-alcoholic fatty liver disease(NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome(Met S). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of Met S. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease(CVD), diabetes mellitus type 2(T2DM) and chronic kidney disease(CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with Met S, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2 DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both(sub-) specialists and primary care physicians. | Ivana Mikolasevic Sandra Milic Tamara Turk Wensveen Ivana Grgic Ivan Jakopcic Davor Stimac Felix Wensveen Lidija Orlic | 2016 | World Journal of Gastroenterology2016，22，43： | 32 |
| 3 | Mobilized bone marrow cells repair the infracted heart, improving function and survival 显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 4 | Preliminary observations regarding angiographic oattern of restenosis after rapamycin-eluting显示文摘 | Orlic D Stankovic G Dimario C | 2003 | Am J Cardiol2003，16，： | 1 |
| 5 | Bone marrow cells regenerate infarcted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，： | 1 |
| 6 | Bone marrow cells regenerate infarcted myocardium显示文摘 | Orlic D Kajastura J Chimenti S | 2001 | Nature2001，410，6829： | 1 |
| 7 | Moblized bone marrow cells repair the infarcted heart, improving function and survival 显示文摘 | ORLIC D KAJSTURA J CHIMENTI S | 2001 | Proc NatAcad Sci USA2001，98，10： | 1 |
| 8 | Bone marrow cells regenerate infarcted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | | 0，，： | 1 |
| 9 | The crushing technique for bifurcation lesions:immediate and mid-term clinical outcome显示文摘 | Airoldi F Stankovic G Orlic D | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 10 | Bone marrow cells regenerate infracted myocardium 显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，6829： | 1 |
| 11 | Bone marrow cell regenerate infarcted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，： | 1 |
| 12 | Bone marrow cells regene-rate infracted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，： | 1 |
| 13 | Mobilized bone marrow cells repair the infarcted heart, improving function and survival显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 14 | Mobilized bone marrow cells repair the infracted heart,improving function and survival显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Proc Natl Acad Sci2001，98，10： | 1 |
| 15 | Stem cells for myocardial regeneration显示文摘 | Orlic D Hill JM Aral AE | 2002 | Cire Res2002，91，12： | 1 |
| 16 | Treatment of multivessel coronary artery disease with sirolimus-eluting stent implantation:immediate and mid-term results显示文摘 | Orlic D Bonizzoni E Stankovic G | 2004 | J Am Coll Cardiol2004，43，7： | 1 |
| 17 | Bone marrow cells regenerate infarcted myocardium 显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，6829： | 1 |
| 18 | Bone marrow cells regenerate infracted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，6829： | 1 |
| 19 | Bone marrow cells regenerate infarcted myocardium显示文摘 | Orlic D Kajstura J Chimenti S | 2001 | Nature2001，410，6829： | 1 |
| 20 | Bone manow stem cells regeamateinfarc~ myoeardium显示文摘 | Orlic D Kajstara J Chirnenfi S | 2003 | Pediatr Transplant2003，73，： | 1 |
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