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| 1 | Hypertension and renal disease显示文摘The relationship between chronic kidney disease(CKD)and hypertension remains enigmatic and a matter of considerable clinical and academic interest with evidence indicating that hypertension is both a cause and a consequence of kidney disease[1-2]. | Huang Chunfa Louis Stokes Cleveland Veteran Affairs Medical Center Division of Nephrology,Departments of Medicine,Case Western Reserve University and Rammelkamp Center for Research and Education,MetroHealth System Campus,Cleveland,Ohio 441061 | 2011 | 中华高血压杂志2011，19，12： | 23 |
| 2 | 同位素地质年代学及在地质学中的应用(英文)显示文摘一些元素(K,Rb,Re,Sm,Lu,U和Th)的自然长寿命放射性同位素,衰变为另种元素稳定同位素的作用,广泛应用于岩石和矿物的年龄测定。这种测年提供了关于地球地质历史的信息,并已用于标定地质年代表。同位素测年的物理原理并不难理解,但所需要的测定技术,则要求同位素地球化学家利用地质人员采集的样品进行熟练精细的操作。对测年结果的解释也应由双方合作进行,并且在很大程度上依靠区域和地区的地质信息。笔者只介绍最广泛应用于测定岩浆岩和变质岩年龄的同位素方法,其余的一些方法只一提而过。 | Gunter Faure(Department of Geological Sciences, The Ohio State University, Columbus, Ohio, USA, 43210) | 1998 | 地学前缘1998，5，1： | 17 |
| 3 | DNA fragmentation in apoptosis显示文摘Cleavage of chromosomal DNA into oligonucleosomal size fragments is an integral part of apoptosis. Elegant biochemical work identified the DNA fragmentation factor (DFF) as a major apoptotic endonuclease for DNA fragmentation in vitro. Genetic studies in mice support the importance of DFF in DNA fragmentation and possibly in apoptosis in vivo. Recent work also suggests the existence of additional endonucleases for DNA degradation. Understanding the roles of individual endonucleases in apoptosis, and how they might coordinate to degrade DNA in different tissues during normal development and homeostasis, as well as in various diseased states, will be a major research focus in the near future. | ZHANG JIAN HUA, MING XU (Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 452670521, USA) | 2000 | Cell Research2000，10，3： | 10 |
| 4 | Fast multipole boundary element analysis of 2D viscoelastic composites with imperfect interfaces显示文摘A fast multipole boundary element method(FMBEM)is developed for the analysis of 2D linear viscoelastic composites with imperfect viscoelastic interfaces.The transformed fast multipole formulations are established using the time domain method. To simulate the viscoelastic behavior of imperfect interfaces that are frequently encountered in practice,the Kelvin type model is introduced.The FMBEM is further improved by incorporating naturally the interaction among inclusions as well as eliminating the phenomenon of material penetration.Since all the integrals are evaluated analytically,high accuracy and fast convergence of the numerical scheme are obtained.Several numerical examples,including planar viscoelastic composites with a single inclusion or randomly distributed multi-inclusions are presented.The numerical results are compared with the developed analytical solutions,which illustrates that the proposed FMBEM is very efficient in determining the macroscopic viscoelastic behavior of the particle-reinforced composites with the presence of imperfect interfaces.The laboratory measurements of the mixture creep compliance of asphalt concrete are also compared with the prediction by the developed model. | ZHU XingYi 1 ,CHEN WeiQiu 2 ,HUANG ZhiYi 1* &LIU YiJun 3 1 Department of Civil Engineering,Zhejiang University,Zijingang Campus,Hangzhou 310058,China 2 Department of Engineering Mechanics,Zhejiang University,Yuquan Campus,Hangzhou 310027,China 3Department of Mechanical Engineering,University of Cincinnati,Cincinnati,Ohio 45221-0072,USA | 2010 | Science China(Technological Sciences)2010，53，8： | 7 |
| 5 | Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss显示文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics. | LIU Xin,1 DAI Pu,1* HUANG Deliang,1 YUAN Huijun,1 LI Weiming,1 YU Fei,1 ZHANG Xin,1 KANG Dongyang,1 CAO Juyang,1 YANG Weiyan,1 HAN Dongyi,1 JIN Zhengce2, GUAN Minxin3 1. Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China2. Weihai Aomaier Gene Technological CO.,LTD.,Weihai,Shandong 264200, China.3. Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA | 2006 | Journal of Otology2006，1，1： | 7 |
| 6 | Effects of Soil Fertility and Atmospheric CO_2 Enrichment on Leaf, Stem and Root Dark Respiration of Populus tremuloides显示文摘An open-top chamber experiment was conducted at the University of Michigan Biological Station near Pellston, Michigan, USA, to study the effects of soil fertility and CO2 on leaf, stem and root dark respiration (Rd) of Populus tremuloides. Overall, area-based day-time leaf Rd (Rda) was significantly greater at elevated than at ambient CO2 in high-fertility soil, but not in low-fertility soil. Mass-based leaf Rd (Rdm) was overall greater for high- than for low-fertility soil grown trees at elected, but not at ambient CO2. Nighttime leaf Rd. and Rdm were unthected by soil fertility or CO2, nor was stem Rda, which ranged from 1.0 to 1.4 μmol m-2 s-1 in the spring and 3.5 to 4.5 μmol m-2 s-1 in the summer. Root Rda. was significantly higher in high- than in low-fertility soil, but was unaffected by CO2. Since biomass production of P. tremuloides will be significantly greater at elevated CO2 while specific Rd will either increase or remain unchanged, we predict that carbon loss to the atmosphere through respiration from this ecologically important species would increase at higher CO2. Soil fertility would also interact with elevated CO2 in affecting the carbon flow in the plant-soil-air system. | X. Z. WANG P. S. CURTIS and C. S. VOGEL Columbia University, Palisades, New York 10964-8000 (USA) The Ohio State University, Columbus, Ohio 43210-1293 (USA) University of Michigan Biological Station, Pellston, Michigan 49769 (USA) | 2001 | Pedosphere2001，11，3： | 6 |
| 7 | Molecular pathogenetic mechanism of maternally inherited deafness显示文摘 | GUAN Min - XinDivision and Program in Human Genetics and Center for Hearing and Deafaess Research,Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, Universityof Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA | 2003 | 中华耳科学杂志2003，1，3： | 6 |
| 8 | MODELING OF CONTROLLED THERMO-MECHANICAL PROCESSING OF TUBES FOR ENHANCED MANUFACTURING AND PERFORMANCE显示文摘An integrated mathematical model to simulate seamless tube rolling processes has been developed at The Timken Company. The model is capable of simulating the thermal, deformation and microstructure evolution in the piercing, elongating and reducing/sizing and the austenite decomposition in the mill annealing and cooling operations. Finite difference schemes are employed to model cooling, reducing/sizing and stretch reducing, and finite-element schemes are employed to simulate piercing and elongating. The model predicts the thermal history, deformation, rolling load, torque, recrystallization and grain growth in hot tube rolling, austenite decomposition in cooling or annealing, and the final structure-properties. In this paper mathematical models which are employed to describe the thermal, deformation and microstructure evolution along with the modeling results are presented. The developed 'tube rolling mill in the computer' provides a powerful tool for engineers for product and process development, process control, process optimization and quality control. | D. Jin E. D. Dominik R. V. Kolarik II J. E. Ives and E. B. Damm (The Timken Company, 1835 Dueber Avenue, S.W., Canton, Ohio 44706-0932, U.S.A.) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 5 |
| 9 | Preface显示文摘A supercomputer has been competitively ranked by its computing speed,memory and storage capacity,andparallel processing scalability year by year. | Xiao-Dong Zhang,Robert M.Critchfield Professor,Department of Computer Science and Engineering The Ohio State University,U.S.A. | 2011 | Journal of Computer Science & Technology2011，26，3： | 4 |
| 10 | Mitochondrial DNA Mutations Associated with Aminoglycoside Ototoxicity显示文摘The mitochondrial 12S rRNA has been shown to be the hot spot for mutations associated with both aminoglycoside-induced and non-syndromic hearing loss. Of all the mutations, the homoplasmic A1555G and C1494T mutations at a highly conserved decoding region in the 12S rRNA have been associated with aminoglycoside-induced and non-syndromic hearing loss in many families worldwide. The A1555G or C1494T mutation is expected to form novel 1494C-G1555 or 1494U-A1555 base-pair at the highly conserved A-site of 12S rRNA. These transitions make the secondary structure of this RNA more closely resemble the corresponding region of bacterial 16S rRNA. Thus, the new U-A or G-C pair in 12S rRNA created by the C1494T or A1555G transition facilitates the binding of aminoglycosides, thereby accounting for the fact that the exposure to aminoglycosides can induce or worsen hearing loss in individuals carrying these mutations. Furthermore, the growth defect and impairment of mitochondrial translation were observed in cell lines carrying the A1555G or C1494T mutation in the presence of high concentration of aminoglycosides. In addition, nuclear modifier genes and mitochondrial haplotypes modulate the phenotypic manifestation of the A1555G and C1494T mutations. These observations provide the direct genetic and biochemical evidences that the A1555G or C1494T mutation is a pathogenic mtDNA mutation associated with aminoglycoside-induced and nonsyndromic hearing loss. Therefore, these data have been providing valuable information and technology to predict which individuals are at risk for ototoxicity, to improve the safety of aminoglycoside antibiotic therapy, and eventually to decrease the incidence of deafness. | GUAN Min-Xin Division of Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA | 2006 | Journal of Otology2006，1，2： | 3 |
| 11 | Jahn-Teller Effect on Binary Indium Bromide─An Ab Initio Study显示文摘In order to elucidate the unusual chemical sensitivity of binary indium bromides. thepotential energy surface of the model complex InBr87- has been studied by means of ah initio all-electron calculation with larger basis sets. The configuration is on a local maximum of the energysurface and crystal potential around In+ is soft, allowing small spontaneous distortions as a result ofa second-order Jahn-Teller instability. | Ke Chen WU Jun LI (State Key Laboratory of Structural Chemistry, Fujian institute of Research on the Structure ofMatter, Chinese Academy of Sciences, Fuzhou 350002)(Department of Chemistry, The Ohio State University. Columbus Ohio 43210, USA) | 1999 | Chinese Chemical Letters1999，10，11： | 3 |
| 12 | Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile显示文摘GESTs (gene expression similarity and taxonomy similarity), a gene functional prediction approach previously proposed by us, is based on gene expression similarity and concept similarity of functional classes defined in Gene Ontology (GO). In this paper, we extend this method to protein-protein interac-tion data by introducing several methods to filter the neighbors in protein interaction networks for a protein of unknown function(s). Unlike other conventional methods, the proposed approach automati-cally selects the most appropriate functional classes as specific as possible during the learning proc-ess, and calls on genes annotated to nearby classes to support the predictions to some small-sized specific classes in GO. Based on the yeast protein-protein interaction information from MIPS and a dataset of gene expression profiles, we assess the performances of our approach for predicting protein functions to “biology process” by three measures particularly designed for functional classes organ-ized in GO. Results show that our method is powerful for widely predicting gene functions with very specific functional terms. Based on the GO database published in December 2004, we predict some proteins whose functions were unknown at that time, and some of the predictions have been confirmed by the new SGD annotation data published in April, 2006. | GAO Lei1, LI Xia1,2, GUO Zheng1,2, ZHU MingZhu1, LI YanHui1 & RAO ShaoQi1,3 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 School of Biology Science and Technology, Tongji University, Shanghai 200092, China 3 Departments of Molecular Cardiology and Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleve-land, Ohio 44195, USA | 2007 | Science China(Life Sciences)2007，50，1： | 3 |
| 13 | Antisense Oligodeoxynucleotide Inhibits Expression of Re-com binantPorcine Follicle-Stim ulating Horm one Receptor显示文摘To assess the role of follicle stimulating hormone receptor(FSHR) gene expression in regulating expression of FSHR protein in the plasma membrane, the effects of a porcine FSHR cDNA antisense oligodeoxynucleotide (ODN) on FSHR mRNA levels and 125 I FSH binding were determined in Chinese hamster ovary cells expression recombinant porcine FSHR (pFSHR CHO cells). An 18 mer phosphorothioate endcapped antisense ODN that corresponded to the region surrounding the translation initiation codon of the porcine FSHR cDNA was synthesized. An 18 mer nonsense sequence of identical nucleotide composition, which had little homology to known DNA sequences, was synthesized for use as a control. pFSHR CHO cells were cultured in 24 well plates (10 5 cells/well) in the absence or presence of 1 20 μmol/L antisense or nonsense ODN for 24 h and then assayed for porcine FSHR mRNA, using quantitative reverse transcription and competitive polymerase chain reaction, and for 125 I FSH binding activity. Treatment with 10 μmol/L antisense ODN caused a paradoxical increase in porcine FSHR mRNA from 0.89±0.06 to 1.64±0.08 ng/mg total RNA ( P <0.05). Transfection with lipofectamine and 0.33 μmol/L antisense ODN caused an increase in porcine mRNA from 0.95±0.08 to 1.53±0.07 ng/mg total RAN. This was probably due to upregulation of mRNA synthesis resulting from inhibition of porcine FSHR protein translation. The nonsense ODN had no effect on porcine FSHR mRNA. Antisense, but not nonsense, ODN (10 μmol/L) inhibited membrane binding of 125 I FSH by 13.6± 0.8 % ( P <0.05) in 24 h. Treatment of cells with antisense ODN (10 μmol/L) for 48 h resulted in a 76±1.5 % ( P <0.05) inhibition of 125 I FSH binding. In contrast, transfection with lipofectamine and 0.33 μmol/L antisense ODN at 0 h caused a 76.1±1.3 % ( P <0.05) reduction in binding within 24 h. Binding had returned to 52.3±2.3 % ( P < 0.05) of normal by 48 h. These results indicate that an antisense ODN corresponding to the region of the translation start site of the porcine FSHR cDNA is an effective specific inhibitor of porcine FSHR synthesis and that inhibition of receptor synthesis causes a decrease in functional membrane bound FSHR. | ZHU Changhong 1, Mark D. Nixon 2, WANG Yifang 1, Andrew R. LaBarbera 3 1 Center of Reproductive Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030 2 Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 3 Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 2 |
| 14 | Challenges and opportunities:a hopeful future of polymer rheology in China显示文摘Polymer rheology has a long research tradition and holds an important position in the scientific community.It is supposed to be a valuable subject to the vast polymer industry.This article points out the exciting developments that are transforming our understanding of the world of polymer rheology.We discuss not only the emerging challenges in the area but also how China might wish to seize the moment,pick up the trend and take advantage of the potential economic benefits to the huge petro-chemical industry of China. | WANG ShiQing Department of Polymer Science,University of Akron,Akron,Ohio,USA | 2010 | Science China Chemistry2010，53，1： | 2 |
| 15 | RECENT DEVELOPMENT OF PROCESS SIMULATION AND ITS APPLICATIONS TO MANUFACTURING PROCESSES显示文摘In this paper, the methodology of an Finite Element Method (FEM) based process modeling program is first described using DEFORMTM as an example. DEFORMTM was originally designed for metal forming applications. While its FEM engine employs the updated Lagrangian method, DEFORMTM includes an automated remeshing procedure so as to continue the simulation when the mesh is severely distorted. Due to its unique remeshing capability, the use of the code has been extended to other manufacturing processes, such as welding, machining, heat treatment and glass forming. The heat treatment enhancement includes the phase transformation kinetics. To demonstrate the methodology, applications of the program to various manufacturing processes such as ingot breakdown, extrusion, forging and heat treatment, are presented in this paper. | WT. Wu,J.P. Tang and G. Li Scientific Forming Technologies Corporation, 5038 Reed Road, Columbus, Ohio 43220-2514, U.S.A. | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 2 |
| 16 | Sound reflection from layered solid medium with rigid and slip interfaces显示文摘In this paper,a general model on sound reflection from a lay-ered solid medium with rigid and slip interfaces is proposed by using ma-trix method.Analytical expressions for reflection coefficients of bothlongitudinal and transverse waves from the layered solid medium with oneor two slip interfaces are derived.Numerical results of sound reflectioncoefficients from some typical adhesive joints with slip and rigid interfacesare presented,which may be useful for correct choice of technicalparameters in ultrasonic evaluation of their interface properties. | WANG Yaojun(Y.J. WANG)(Institute of Acoustics, Nanjing University, 210008)S. I. Rokhlin(Department of Welding Engineering, The Ohio State University, U. S. A.) | 1991 | Chinese Journal of Acoustics1991，10，4： | 2 |
| 17 | Prevention of post transfusion graft versus host disease显示文摘 | Tasaki T Ohio H Abe R | 1993 | Fukushima J Med sci1993，39，2： | 1 |
| 18 | Assessing and Ex-plaining the Relative Efficiency of Local Government显示文摘 | Ant'ohio Afonso S'onia Fernandes | 2008 | The Journal of Socio-Economics2008，，37： | 1 |
| 19 | STATUS UP DATE ON USE OF INTERMETALLICS FOR STRUCTURAL APPLICATIONS显示文摘Several key issues related to ductility and fracture toughness limiting the application of intermetallics were discussed. Progress made in resolving some of the issues was discussed. The paper addresses design methodology for low defect tolerant materials. Impact resistance of NiAl under engine simulative conditions has been studied. The impact test results demonstrated a need for materials possessing improved impact resistance for turbine blade and vane applications. Some of the production implementation issues were also discussed. | R.Darolia GE Aircraft Engines, 1 Neumann Way, Cincinnati, Ohio 45215, U.S.A. | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 1 |
| 20 | Further studies on experimental endometriosis 显示文摘 | Scott RB Ohio C Te Linde RW | 1953 | Am J Obstet Gynecol1953，66，： | 1 |
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