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| 1 | Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study显示文摘AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life(QOL) of patients after gastrectomy.METHODS The postgastrectomy syndrome assessment scale(PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy(TG) reconstructed with Roux-Y(n = 393), distal gastrectomy(DG) reconstructed with Billroth-I(n = 909), or DG reconstructed with Roux-Y(n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL(i.e., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis(MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA.RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients' QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factorsto the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity(especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients' wellbeing after gastrectomy. | Koji Nakada Masazumi Takahashi Masami Ikeda Shinichi Kinami Masashi Yoshida Yoshikazu Uenosono Yoshiyuki Kawashima Sayumi Nakao Atsushi Oshio Yoshimi Suzukamo Masanori Terashima Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 2 | Development and validation of a simple and multifaceted instrument,GERD-TEST,for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms显示文摘AIM To evaluate the psychometric properties of a newly developed questionnaire,known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test(GERD-TEST),in patients with GERD.METHODS Japanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor(PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey(SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia(FD) symptoms(5 items),the level of dissatisfaction with daily life(DS)(4 items),and the therapeutic efficacy as assessed by the patients and medication compliance(4 items).RESULTS A total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach's α values for the GERD,FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD,FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment,the scores for the GERD items/subscales were greatly reduced,ranging in value from 1.51 to 1.87 and with a large effect size(P < 0.0001,Cohen's d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders(P < 0.0001).CONCLUSION The GERD-TEST has a good reliability,a good convergent and concurrent validity,and is responsive to the effects of treatment. The GERD-TEST is a simple,easy to understand,and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients. | Koji Nakada Nobuyuki Matsuhashi Katsuhiko Iwakiri Atsushi Oshio Takashi Joh Kazuhide Higuchi Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，28： | 3 |
| 3 | Faring technique for preparing a BaMgAl10O17:Eu2+ phosphor with controlled particle shape and size 显示文摘 | Oshio S Kitamura K Shigeta T | 1999 | Electrochemical Society1999，146，1： | 2 |
| 4 | Firing technique for preparing a BaMgAl10O17:Eu2+ phosphor with controlled particle shape and size显示文摘 | Oshio S Kitamura K Shigeta T | 1999 | J Electrochem Soc1999，146，1： | 1 |
| 5 | Biexponential apparent diffusion coefficients in prostate cancer显示文摘 | Shinmoto H Oshio K Tanimoto A | 2009 | Magn Reson Imaging2009，27，3： | 1 |
| 6 | Optimization of chemical shift selective suppression of fat显示文摘 | Kuroda K Oshio K Mulkern RV | 1998 | Magn Reson Med1998，40，4： | 1 |
| 7 | Tz-weighted thin-section imaging with the multislab three-dimensional RARE technique 显示文摘 | Oshio K Jolesz F A Melki P S | 1991 | J MagnResonImaging1991，1，6： | 1 |
| 8 | Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparoto- my 显示文摘 | Kawashima R Kawamura YI Oshio T | 2012 | J Immunoassay Immunochem2012，33，3： | 1 |
| 9 | Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice显示文摘 | Solenov EI Vetrivel L Oshio K | 2002 | J Neurosci Methods2002，113，1： | 1 |
| 10 | Social Security and Trust Fund Management显示文摘 | Takashi Oshio | | 0，，： | 1 |
| 11 | Iridoid Glycosides of Rehmannia Glutinosa显示文摘 | Haruji Oshio Hiroyuki Inouye | 1981 | Phytochemistry1981，21，1： | 1 |
| 12 | In utero exposure to a low concentration of diesel exhaust affects spontaneous lo- comotor activity and monoaminergie system in male mice 显示文摘 | Suzuki T Oshio S Iwata M | 2010 | Particle and Fibre Toxicology2010，7，1： | 1 |
| 13 | Firing technique for preparing a BaMgAl10 O17 : Eu^2+ phosphor with controlled particle shape and size 显示文摘 | Oshio S Kitamura K Shigeta T | 1999 | J Eleetrochem Soc1999，146，1： | 1 |
| 14 | Expression of aquaporin water channels in mouse spinal cord显示文摘 | Oshio K Binder DK Yang B | 2004 | Neuroscience2004，127，3： | 1 |
| 15 | Firing technique for preparing a BaMgAl10O17:Eu2+ phosphor with controlled partical shape and size显示文摘 | OSHIO S MATSUOKA T TANAKA S | 1998 | J Electrochem Soc1998，154，： | 1 |
| 16 | Expression of the aquaporin-1 water channel in human glail tumors显示文摘 | Oshio K Binder DK Liang Y | 2005 | Neurosurgery2005，52，2： | 1 |
| 17 | Increased seizure threshold in mice laeking aquapofin4 water channels显示文摘 | Binder DK Oshio K Ma T | 2004 | Neuroreport2004，15，2： | 1 |
| 18 | Quantitative assess- ment of jliomas by proton meganetic resonance spect ros- :opy显示文摘 | Oshio S Tsugu H Komatsu F | 2007 | Anticancer Res2007，27，6： | 1 |
| 19 | Comparison of effects of six main gastrectomy procedures on patients’ quality of life assessed by Postgastrectomy Syndrome Assessment Scale-45显示文摘BACKGROUND The effects of various gastrectomy procedures on the patient’s quality of life(QOL)are not well understood.Thus,this nationwide multi-institutional crosssectional study using the Postgastrectomy Syndrome Assessment Scale-45(PGSAS-45),a well-established questionnaire designed to clarify the severity and characteristics of the postgastrectomy syndrome,was conducted.AIM To compare the effects of six main gastrectomy procedures on the postoperative QOL.METHODS Eligible questionnaires retrieved from 2368 patients who underwent either of six gastrectomy procedures[total gastrectomy with Roux-en-Y reconstruction(TGRY;n=393),proximal gastrectomy(PG;n=193),distal gastrectomy with Roux-en-Y reconstruction(DGRY;n=475),distal gastrectomy with Billroth-I reconstruction(DGBI;n=909),pylorus-preserving gastrectomy(PPG;n=313),and local resection of the stomach(LR;n=85)]were analyzed.Among the 19 main outcome measures of PGSAS-45,the severity and characteristics of postgastrectomy syndrome were compared for the aforementioned six gastrectomy procedures using analysis of means.RESULTS TGRY and PG significantly impaired the QOL of postoperative patients.Postoperative QOL was excellent in LR(cardia and pylorus were preserved with minimal resection).In procedures removing the distal stomach,diarrhea subscale(SS)and dumping SS were less frequent in PPG than in DGBI and DGRY.However,there was no difference in the postoperative QOL between DGBI and DGRY.The most noticeable adverse effects caused by gastrectomy were mealrelated distress SS,dissatisfaction at the meal,and weight loss,with significant differences among the surgical procedures.CONCLUSION Postoperative QOL greatly differed among six gastrectomy procedures.The severity and characteristics of postgastrectomy syndrome should be considered to select gastrectomy procedures,overcome surgical shortcomings,and enhance postoperative care. | Koji Nakada Yoshiyuki Kawashima Shinichi Kinami Ryoji Fukushima Hiroshi Yabusaki Akiyoshi Seshimo Naoki Hiki Keisuke Koeda Mikihiro Kano Yoshikazu Uenosono Atsushi Oshio Yasuhiro Kodera | 2021 | World Journal of Gastrointestinal Surgery2021，13，5： | 1 |
| 20 | Heterotopic pancreas in children: review of the literature and report of 12 cases显示文摘 | Ogata H Oshio T Ishibashi H | 2008 | Pediatr Surg Int2008，24，7： | 1 |
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