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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | 三种糖醇对海绵蛋糕面糊流变学、热力学及烘焙学特性影响的比较研究显示文摘以三种糖醇(麦芽糖醇(Mal)、木糖醇(Xyl)和赤藓糖醇(Ery))分别完全替代海绵蛋糕中的蔗糖,比较它们对海绵蛋糕面糊流变学、热力学和烘焙学特性的影响。主要采用旋转流变仪、显微照相仪、差示扫描量热仪(DSC)、测色仪和质构仪等分别研究了三种糖醇对面糊黏度特性、微观结构、糊化性质以及蛋糕比容、颜色、质构和感官品质等的影响。结果表明:Mal对面糊特性无显著影响(p>0.05),减弱了蛋糕皮红色色调(a*),增强了其亮度(L*);Xyl主要显著降低了面糊比重(p<0.05),降低了淀粉糊化起始和峰值温度,显著增大了蛋糕硬度(p<0.05),但感官评定结果显示,用Mal和Xyl分别完全取代海绵蛋糕中蔗糖后,蛋糕总体质量仍可接受;Ery显著增大了面糊比重、减小了面糊黏度、降低了面糊中气泡均匀性和淀粉糊化温度(p<0.05),对蛋糕比容、质构、颜色和感官特性都产生了不利影响,感官评定结果发现其总体质量不可接受。 | 郝月慧 贾春利 王凤 黄卫宁 郑建仙 Akihiro Ogawa | 2014 | 食品工业科技2014，35，6： | 31 |
| 3 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 4 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 5 | Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility显示文摘瞄准:为了评估在阴囊的功能和阴囊的体积之间的关系,由使用 Prader orchidometry 和 ultrasonography (美国) 决定由每个方法显示正常阴囊的功能的批评的阴囊的卷测量了。方法:全部的阴囊的体积(恰好正的左阴囊的体积) 与不孕在 397 个人在 794 个睾丸被测量(吝啬的年龄, 35.6 年) 用 Prader orchidometer 并且也由 ultrasonography。Ultrasonographic 阴囊的体积作为长度×宽度×高度×被计算 0.71。评估卷功能关系,病人们被划分成从在 10 mL 下面由每个方法代表全部的阴囊的体积的 5-mL 增长到 50 mL 或更多的 10 个组。结果:吝啬的全部的阴囊的体积分别地基于 Prader orchidometry 和美国是 36.8 mL 和 26.3 mL。精液体积,精子密度,全部的精子计数,全部的能动精子计数,和浆液 FSH, LH,和睾丸激素都显著地相关,全部的阴囊的体积由任何一个方法测量了。吝啬的精子密度在在有在由 orchidometry 或在由 ultrasonography 的 20 mL 下面的 35 mL 下面的全部的阴囊的体积的病人的 oligozoospermic 范围。吝啬的全部的精子计数由 ultrasonography 在有在由 orchidometry 或不到 20 mL 的 30 mL 下面的全部的阴囊的体积的病人是低于正常的。结论:ultrasonography 或 Prader orchidometry 测量的阴囊的体积与阴囊的功能显著地相关。然而,批评全部的阴囊的体积显示正常或将近正常的阴囊的功能用 ultrasonography 是到用 Prader orchidometer 和 20 mL 的 35 mL 的 30 mL。Prader orchidometry morphometrically 并且机能上地与美国相比过高估计阴囊的体积。 | Hideo Sakamoto Yoshio Ogawa Hideki Yoshida | 2008 | Asian Journal of Andrology2008，10，2： | 25 |
| 6 | Randomized controlled trial of pancreatic stenting to prevent pancreatitis after endoscopic retrograde cholangiopancreatography显示文摘AIM:To determine the effectiveness of pancreatic duct(PD) stent placement for the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP) in high risk patients.METHODS:Authors conducted a single-blind,randomized controlled trial to evaluate the effectiveness of a pancreatic spontaneous dislodgement stent against post-ERCP pancreatitis,including rates of spontaneous dislodgement and complications.Authors defined high risk patients as having any of the following:sphincter of Oddi dysfunction,difficult cannulation,prior history of post-ERCP pancreatitis,pre-cut sphincterotomy,pancreatic ductal biopsy,pancreatic sphincterotomy,intraductal ultrasonography,or a procedure time of more than 30 min.Patients were randomized to a stent group(n = 60) or to a non-stent group(n = 60).An abdominal radiograph was obtained daily to assessspontaneous stent dislodgement.Post-ERCP pancreatitis was diagnosed according to consensus criteria.RESULTS:The mean age(± standard deviation) was 67.4 ± 13.8 years and the male:female ratio was 68:52.In the stent group,the mean age was 66 ± 13 years and the male:female ratio was 33:27,and in the non-stent group,the mean age was 68 ± 14 years and the male:female ratio was 35:25.There were no significant differences between groups with respect to age,gender,final diagnosis,or type of endoscopic intervention.The frequency of post-ERCP pancreatitis in PD stent and non-stent groups was 1.7%(1/60) and 13.3%(8/60),respectively.The severity of pancreatitis was mild in all cases.The frequency of post-ERCP pancreatitis in the stent group was significantly lower than in the non-stent group(P = 0.032,Fisher's exact test).The rate of hyperamylasemia were 30%(18/60) and 38.3%(23 of 60) in the stent and non-stent groups,respectively(P = 0.05,χ2 test).The placement of a PD stent was successful in all 60 patients.The rate of spontaneous dislodgement by the third day was 96.7%(58/60),and the median(range) time to dislodgement was 2.1(2-3) d.The rates of stent migration,hemorrhage,perforation,infection(cholangitis or cholecystitis) or other complicationss were 0%(0/60),0%(0/60),0%(0/60),0%(0/60),0%(0/60),respectively,in the stent group.Univariate analysis revealed no significant differences in high risk factors between the two groups.The pancreatic spontaneous dislodgement stent safely prevented post-ERCP pancreatitis in high risk patients.CONCLUSION:Pancreatic stent placement is a safe and effective technique to prevent post-ERCP pancreatitis.Therefore authors recommend pancreatic stent placement after ERCP in high risk patients. | Yoshiaki Kawaguchi Masami Ogawa Fumio Omata Hiroyuki Ito Tooru Shimosegawa Tetsuya Mine | 2012 | World Journal of Gastroenterology2012，18，14： | 25 |
| 7 | Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review显示文摘A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver tumor.As diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the liver.The lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively rare.Moreover,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of PEComa.In addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to enlarge.Therefore,a PEComa is difficult to diagnose.We conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors. | Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani | 2015 | World Journal of Gastroenterology2015，21，17： | 20 |
| 8 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 9 | Surgery for scar revision and reduction:from primary closure to flap surgery显示文摘Scars are the final result of the four processes that constitute cutaneous wound healing,namely,coagulation,inflammation,proliferation,and remodeling.Permanent scars are produced if the wounds reach the reticular dermis.The nature of these scars depends on the four wound healing processes.If the remodeling process is excessive,collagen degradation exceeds collagen synthesis and atrophic scars are produced.If the inflammation phase is prolonged and/or more potent for some reason,inflammatory/pathological scars such as keloids or hypertrophic scars can arise.If these pathological scars are located on joints or mobile regions,scar contractures can develop.When used with the appropriate timing and when selected on the basis of individual factors,surgical techniques can improve mature scars.This review paper focuses on the surgical techniques that are used to improve mature scars,burn scars,and scar contractures.Those methods include z-plasties,w-plasties,split-thickness skin grafting,full-thickness skin grafting,local flaps(including the square flap method and the propeller flap),and expanded flaps,distant flaps,regional flaps,and free flaps. | Rei Ogawa | 2019 | Burns & Trauma2019，7，1： | 17 |
| 10 | Chronic atrophic gastritis detection with a convolutional neural network considering stomach regions显示文摘BACKGROUND The risk of gastric cancer increases in patients with Helicobacter pylori-associated chronic atrophic gastritis(CAG).X-ray examination can evaluate the condition of the stomach,and it can be used for gastric cancer mass screening.However,skilled doctors for interpretation of X-ray examination are decreasing due to the diverse of inspections.AIM To evaluate the effectiveness of stomach regions that are automatically estimated by a deep learning-based model for CAG detection.METHODS We used 815 gastric X-ray images(GXIs)obtained from 815 subjects.The ground truth of this study was the diagnostic results in X-ray and endoscopic examinations.For a part of GXIs for training,the stomach regions are manually annotated.A model for automatic estimation of the stomach regions is trained with the GXIs.For the rest of them,the stomach regions are automatically estimated.Finally,a model for automatic CAG detection is trained with all GXIs for training.RESULTS In the case that the stomach regions were manually annotated for only 10 GXIs and 30 GXIs,the harmonic mean of sensitivity and specificity of CAG detection were 0.955±0.002 and 0.963±0.004,respectively.CONCLUSION By estimating stomach regions automatically,our method contributes to the reduction of the workload of manual annotation and the accurate detection of the CAG. | Misaki Kanai Ren Togo Takahiro Ogawa Miki Haseyama | 2020 | World Journal of Gastroenterology2020，26，25： | 17 |
| 11 | 糖醇对鸡蛋液功能特性及无糖海绵蛋糕烘焙品质的影响显示文摘本研究用麦芽糖醇(Mal)、木糖醇(Xyl)和赤藓糖醇(Ery)取代海绵蛋糕配方中的蔗糖,分别研究其对鸡蛋液黏度、表面张力、起泡性、泡沫稳定性、鸡蛋蛋白质变性温度,以及无糖海绵蛋糕烘焙品质和蛋白质、淀粉结合状态的影响。结果表明,与蔗糖相比,麦芽糖醇会显著降低鸡蛋液的表面张力(p<0.05),气泡稳定性较好,虽然麦芽糖醇无糖海绵蛋糕中心高度与蔗糖组相比有显著下降(p<0.05),但是对蛋糕内部气孔密度CD值以及蛋糕芯淀粉和蛋白质结合状态无显著影响,蛋糕品质在三种糖醇中最好;木糖醇对鸡蛋蛋白质起泡性和泡沫稳定性无显著影响,但使蛋白质变性温度和蛋糕芯密度CD值显著下降(p<0.05),蛋糕内部观察不到裸露的淀粉颗粒;赤藓糖醇对鸡蛋蛋白质的影响作用相比蔗糖最为显著(p<0.05),其蛋糕品质和蔗糖海棉蛋糕相比下降最为显著(p<0.05)。 | 郝月慧 汤晓娟 黄卫宁 贾春利 张峦 李宁 Akihiro Ogawa | 2015 | 食品工业科技2015，36，3： | 16 |
| 12 | Chinese Yuan after Chinese Exchange Rate System Reform显示文摘In this paper, the actual exchange rate policy conducted by the Chinese government after the Chinese exchange rate system reform on 21 July 2005 is investigated. Also, the long-run effect is investigated, including the Balassa-Samuelson effect on the Chinese yuan. It was found that the Chinese government generated a statistically significant but small change in exchange rate policy during the sample period until 25 January 2006. It was not identified that the Chinese monetary authority is adopting the currency basket system because the change is too small in the economic sense. It is indicated that the Chinese government should take account of the productivity growth of countries composing the currency basket in order to operate a currency basket regime. | Eiji Ogawa Michiru Sakane | 2006 | China & World Economy2006，14，6： | 15 |
| 13 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 14 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 15 | Science:'记忆碎片'是真的吗?显示文摘半个多世纪以来,神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的,因为两种类型的记忆(长期与短期)能够同时产生。这项研究是由来自MIT的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段,并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。 | Takashi Kitamura Mark D. Morrissey Lillian M. Smith Roger L. Redondo | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 16 | Advanced diffusion magnetic resonance imaging in patients with Alzheimer’s and Parkinson’s diseases显示文摘The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings;however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively. | Koji Kamagata Christina Andica Taku Hatano Takashi Ogawa Haruka Takeshige-Amano Kotaro Ogaki Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki | 2020 | Neural Regeneration Research2020，15，9： | 11 |
| 17 | Direct Dimethyl Ether Synthesis显示文摘Dimethyl ether (DME) is a clean and economical alternative fuel which can be produced from natural gas through synthesis gas. The properties of DME are very similar to those of LP gas. DME can be used for various fields as a fuel such as power generation, transportation, home heating and cooking,etc. It contains no sulfur or nitrogen. It is not corrosive to any metal and not harmful to human body. An innovative process of direct synthesis of DME from synthesis gas has been developed. Newly developed catalyst in a slurry phase reactor gave a high conversion and high selectivity of DME production. One and half year pilot scale plant (5 tons per day) testing, which was supported by METI, had successfully finished with about 400 tons DME production. | Takashi Ogawa Norio Inoue Tutomu Shikada Yotaro Ohno | 2003 | Journal of Natural Gas Chemistry2003，12，4： | 11 |
| 18 | 超声波辅助农杆菌介导CP基因转化番小瓜(Carioca papaya L.)的有效方法显示文摘本研究探索了通过农杆菌介导,超声波辅助处理,转化番木瓜胚性愈伤组织,获得转基因植株的有效方法。分别将含有日本PLDMV 外壳蛋白基因(PTi-Epj-TL-PLDMV)和含有台湾PRSV 菌株、美国夏威夷PRSV 菌株、泰国PRSV 菌株及日本PLDMV 菌株的多元外壳蛋白基因编码序列(PTi-NP-YKT)插入双元载体质粒pGA482G,借助于农杆菌系LBA4404将双元载体上的外壳蛋白基因和新霉素磷酸转移酶基因(nptⅡ)转移到番木瓜品种Sunset 的胚性愈伤组织中,从而获得抗卡那霉素的转化再生植株。试验着重在转化方法上进行探索。结果表明,农杆菌过夜培养后,用高渗透压培养液(1/2 MS+6%蔗糖+1%葡萄糖,pH 5.7)调整至光密度OD_(600(?)m)=0.15-0.20,然后用该菌液感染材料30min,其间辅以超声波处理,可以大大提高转化效率。用15ml 无菌离心管装载胚性愈伤材料进行15s 的超声波处理,在80块被转化的胚性愈伤中获得21个CP 基因G 转化系(26.3%),而在对照处理64块胚性愈伤中仅获得1个转化系(1.6%);在经过15s 的超声波处理48块被转化的胚性愈伤中获得8个CP 基因B 转化系(16.7%),而在对照处理25块胚性愈伤中未出现转化系。上述操作方法用在两种CP 基因转化上均表现出相似的效果。试验还表明:120mg/L 是卡那霉素抗性筛选的最佳浓度。抗性筛选9个月后,在421块胚性愈伤组织中产生了42个抗卡那霉素的转化系。所获得的转基因植株分别用PCR 和Southern 印迹杂交进行了鉴定。 | 姜玲 MAOKA Tetsuo KOMORI Sadao FUKAMACHI Hiroshi KATO Hidenori OGAWA Kazunori | 2004 | 实验生物学报2004，37，3： | 11 |
| 19 | Adipose tissues differentiated by adipose-derived stem cells harvested from transgenic mice显示文摘客观:为了由 adipose-derivedstromal 房间(ASC ) 在 vitro 导致 adipocyte 区别,与绿荧光灯的蛋白质(GFP ) 从转基因的老鼠收获了并且估计经由 ASC 的附件构造脂肪质的纸巾打字的可能性我骨胶原 scaffolds.Methods:从 GFP 转基因的老鼠的腹股沟的胖垫被酶为 ASC (主要文化) 的隔离消化。在到 ASC 的三个段落的扩大以后,房间被 ASC 在 vitro 在为二个星期,和 adipocyte 区别中等的 anadipogenic 孵化被词法观察和油红估计染色的 O。然后,他们被纳入为 12 个小时 andco 有教养的骨胶原脚手架,为 2months 由皮下注射的培植列在后面到裸体老鼠的背面的皮肤。最新形成的纸巾被检测由他染色。结果:有教养的主要干细胞是像成纤维细胞、显示出的活跃增长。在在 anadipocyte 区别媒介被孵化以后,在逐渐地并且最后积累的细胞质的类脂化合物微滴发展成成熟 adipocytes,它出现了在染色的油红 O 积极。0。5 厘米的 ~ 3new 组织块在裸体老鼠的背面的皮下面被发现,它被荧光灯的观察作为成熟脂肪质的纸巾证实并且他染色。结论:ASC 能成功地区分脂肪质的纸巾进成熟 adipocytes,它作为 intracytoplasmic 类脂化合物微滴展出象 adipocyte 一样形态学和快车。它是与 ASC 和类型设计的脂肪质的纸巾的一个有效模特儿我骨胶原脚手架。 | 鲁峰 高建华 Rei Ogawa Hiroshi Mizuro Hiki Hykusoku | 2006 | Chinese Journal of Traumatology2006，9，6： | 10 |
| 20 | ^(85)Sr、^(134)Cs和^(60)Co在浅地层黄土与地下水间的分配系显示文摘本文报道了￣(85)Sr、￣(134)Cs和￣(60)Co在采自本院野外试验场,从地表到地下2m深黄土与地下水间分配系数的测定结果,以及核素浓度、pH和温度对分配系数的影响。黄土采集的深度范围分别为:地表-0.5m,0.5-1m,1-1.5m,1.5-2m,共采集16个样品;地下水取自试验场的井水。实验采用静态法。实验结果表明,16个样品测定的￣(85)Sr、￣(134)Cs和￣(60)Co的分配系数的均值分别为82、7.4×10￣3和5.4×10￣3mL/g;在不同深度的黄土中测得的分配系数基本一致。pH值的变化对￣(134)Cs和￣(85)Sr的分配系数有较大影响,对￣(60)Co则影响不大。 | 李祯堂 王辉 游志均 Tadao Tanaka Hiromichi Ogawa Hidao Kamiyama | 1995 | 辐射防护1995，15，2： | 10 |
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