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| 1 | Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules显示文摘AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related HCC.METHODS: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically analyzed.RESULTS: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic metastasis.CONCLUSION: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis. | Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park | 2005 | World Journal of Gastroenterology2005，11，14： | 62 |
| 2 | Conodont Biostratigraphy of the Middle Cambrian through Lowermost Ordovician in Hunan, South China显示文摘Since 1985, samples with a total weight of more than 14,000 kg, mainly from three key sections in western and northwestern Hunan, South China, have been processed for conodonts. In strata older than the late Late Cambrian paraconodonts have proved useful for stratigraphic subdivision and correlation. Thirteen conodont zones are proposed in the Middle Cambrian through lowermost Ordovician. The correlation between these zones and those of North China, western U.S.A., western Newfoundland, Canada, and Iran is discussed. In ascending order, these 13 zones are as follows: The Gapparodus bisulcatus-Westergaardodina brevidens Zone, Shandongodus priscus-Hunanognathus tricuspidatus Zone,Westergaardodina quadrata Zone, Westergaardodina matsushitai-W. grandidens Zone, Westergaardodina lui-W. ani Zone,Westergaardodina cf. calix-Prooneotodus rotundatus Zone, Proconodontus tenuiserratus Zone, Proconodontus Zone,Eoconodontus Zone, Cordylodus proavus Zone, Cordylodus intermedius Zone, Cordylodus lindstromi Zone, and Cordylodus angulatus Zone (lower part). The Westergaardodina lui-W. ani and Westergaardodina cf. calix-Prooneotodus rotundatus Zones replace the Westergaardodina proligula and Westergaardodina cf. behrae-Prooneotodus rotundatus Zones, respectively, in the lowermost Upper Cambrian. Two new species (Westergaardodina lui and Westergaardodina ani)and one conditionally identified species (Westergaardodina cf. calix) are described. | DONGXiping JohnE.REPETSKI StigM.BERGSTR(OE)M | 2004 | Acta Geologica Sinica(English Edition)2004，78，6： | 29 |
| 3 | TLR8激动剂GS-9688在慢性乙型肝炎中的治疗潜力——抗病毒和调节介质的重塑显示文摘GS-9688(Selgantolimod)是一种用于治疗慢性乙型肝炎的Toll样受体8(TLR8)激动剂,目前正处于临床研究阶段。GS-9688的抗病毒活性之前已经在感染HBV的肝细胞中进行了体外评估,并在慢性乙型肝炎的土拨鼠模型中进行了体内评估。该研究评估了GS-9688增强应答有助于病毒控制和调节介质的潜力。 | AMIN OE COLBECK EJ DAFFIS S 阿米那·阿不力孜 华瑞 | 2021 | 临床肝胆病杂志2021，37，3： | 4 |
| 4 | 根据基础降压用药分析恩格列净在2型糖尿病合并高血压患者中的降压作用显示文摘在EMPA—REG血压试验中,与安慰剂比较,恩格列净(empagliflozin)10或25mg/d可降低2型糖尿病合并高血压患者的糖化血红蛋白、血压及体质量水平。 | Mancia G Cannon CP Tikkanen I Zeller C Ley L Woerle HJ Broedl UC Johansen OE 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 5 | A comparative laboratory diagnosis of malaria:microscopy versus rapid diagnostic test kits显示文摘Objective:To compare the two methods of rapid diagnostic tests(RDTs)and microscopy in the diagnosis of malaria.Methods:RDTs and microscopy were carried out to diagnose malaria. Percentage malaria parasitaemia was calculated on thin films and all non-acute cases of plasmodiasis with less than 0.001%malaria parasitaemia were regarded as negative.Results were simply presented as percentage positive of the total number of patients under study.The results of RDTs were compared to those of microscopy while those of RDTs based on antigen were compared to those of RDTs based on antibody.Patients' follow-up was made for all cases.Results: All the 200 patients under present study tested positive to RDTs based on malaria antibodies(serum)method(100%).128 out of 200 tested positive to RDTs based on malaria antigen(whole blood)method(64%),while 118 out of 200 patients under present study tested positive to visual microscopy of Lieshman and diluted Giemsa(59%).All patients that tested positive to microscopy also tested positive to RDTs based on antigen.All patients on the second day of follow-up were non-febrile and had antimalaria drugs.Conclusions;We conclude based on the present study that the RDTs based on malaria antigen(whole blood)method is as specific as the traditional microscopy and even appears more sensitive than microscopy.The RDTs based on antibody(serum)method is unspecific thus it should not be encouraged.It is most likely that Africa being an endemic region,formation of certain levels of malaria antibody may not be uncommon.The present study also supports the opinion that a good number of febrile cases is not due to malaria. We support WHO's report on cost effectiveness of RDTs but,recommend that only the antigen based method should possibly,be adopted in Africa and other malaria endemic regions of the world. | Azikiwe CCA Ifezulike CC Siminialayi IM Amazu LU Enye JC Nwakwunite OE | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 6 | The influence of bulges produced by laser surface texturing on the sliding friction and wear behavior显示文摘 | Auezhan Amanov Ryo Tsuboi Hironobu Oe Shinya Sasaki | 2013 | Tribology International2013，，： | 2 |
| 7 | Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy 显示文摘 | Tanis PJ Nieweg OE Valdes Olmos RA | 2001 | J Am Coll Surg2001，192，3： | 1 |
| 8 | The effect of pineal ectomy and foetal pineal transplantation of collagen aging in rats显示文摘 | Palaoglu S Ozean OE | 1996 | Acta Neurochir1996，138，： | 1 |
| 9 | Frequency and timing of clinical venous thromboembolism after major joint surgery显示文摘 | Gudmundsen TE Dahl OE | 2006 | J Bone Joint Surg Br2006，88，3： | 1 |
| 10 | Fatal vascular outcomes following major orthopedic surgery显示文摘 | Dahl OE Caprini JA Colwell CW Jr | 2005 | Thromb Haemost2005，93，5： | 1 |
| 11 | Reliability of intraocular pressure measurements after myopic excimer photorefractive keratectomy显示文摘 | Abbasoglu OE Bowman RW Cavanagh HD | 1998 | Ophthalmology1998，105，12： | 1 |
| 12 | Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium 显示文摘 | Ao M Franco OE Park D | 2007 | Cancer Res2007，67，： | 1 |
| 13 | Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide显示文摘 | Armstrong BD Abad C Chhith S Cheung-Lau G Hajji OE Nobuta H | 2008 | Neuroscience2008，151，1： | 1 |
| 14 | High prevalence of au-toimmune thyroiditis in patients with polycystic ovary syndrome显示文摘 | Janssen OE Mehlmauer N Hahn S | 2004 | EurJ Endocrinol2004，150，3： | 1 |
| 15 | Comparative study between valve repair and replacement for mitral pure regurgitation--early and late postoperative results显示文摘 | Kawachi Y Oe M Asou T | 1991 | Jpn Circ J1991，55，5： | 1 |
| 16 | Socioeconomic inequities and payment coping mechanisms used in the treatment of type 2 diabetes mellitus in Nigeria显示文摘 | Okoronkwo IL Ekpemiro JN Onwujekwe OE | 2016 | Niger J Clin Pract2016，19，1： | 1 |
| 17 | Neurological and MRI findings as predictors of progressive-type lacunar infarction显示文摘 | Nagakane Y Naritomi H Oe H | 2008 | Eur Neurol2008，60，3： | 1 |
| 18 | The Clinical Value of Myocardial Blood FlowMeasurement显示文摘 | Camici PG Rimoldi OE | 2009 | J Nucl Med2009，50，7： | 1 |
| 19 | Prevalence of thyroid nodules in the valley of Mexico 显示文摘 | Hurtado LL Basurto KE Mantes OE | 2011 | Cir2011，79，2： | 1 |
| 20 | CUTLI is a target of TGFI3signaling that enhances cancer cell motility and invasiveness 显示文摘 | Miehl P Ramjaun AR Pardo OE | 2005 | Cancer Cell2005，7，6： | 1 |
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