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| 1 | 产后出血的预防和处理指南显示文摘目的:为产后出血(PPH)的预防和临床处理作一综述,为临床医师提供预防和处理产后出血的指南。涉及方面:预防、适当干预、使其影响最小化的方法。结果:建立常规,便于临床医师鉴别可能的高危人群,一旦发生产后过多出血,可指导临床如何迅速处理。证据:遵循加拿大定期健康检查办公室制定的证据等级。评估:由产科专家完善。利弊和成本:评估子宫收缩药和其他积极处理措施的方便性、正确性、有效性和安全性。建议:根据证据的等级,本指南分等级列出了12条建议。确认:按照MeSH词表推荐的postpartum haemorrhage在medline上查询相关文献,在Cochrane图书馆查找相关研究文献,并参考the ALARMcourse Manual。发起人:由产科临床实践委员会制定和综述,并由SOGC(加拿大妇产科协会)委员会批准。 | Nan Schuurmans MD FRCSC, Edmonton AB Catherine MacKinnon MD FRCSC, Brantford ON Carolyn Lane MD CCFP Calgary AB Duncan Etches MD CCFP Vancouver BC 刘铭(译) 段涛(译) | 2007 | 现代妇产科进展2007，16，3： | 152 |
| 2 | A statistical model for porous structure of rocks显示文摘The geometric features and the distribution properties of pores in rocks were in- vestigated by means of CT scanning tests of sandstones. The centroidal coordi- nates of pores, the statistic characterristics of pore distance, quantity, size and their probability density functions were formulated in this paper. The Monte Carlo method and the random number generating algorithm were employed to generate two series of random numbers with the desired statistic characteristics and prob- ability density functions upon which the random distribution of pore position, dis- tance and quantity were determined. A three-dimensional porous structural model of sandstone was constructed based on the FLAC3D program and the information of the pore position and distribution that the series of random numbers defined. On the basis of modelling, the Brazil split tests of rock discs were carried out to ex- amine the stress distribution, the pattern of element failure and the inosculation of failed elements. The simulation indicated that the proposed model was consistent with the realistic porous structure of rock in terms of their statistic properties of pores and geometric similarity. The built-up model disclosed the influence of pores on the stress distribution, failure mode of material elements and the inosculation of failed elements. | JU Yang1,2, YANG YongMing1, SONG ZhenDuo3 & XU WenJing4 1 State Key Laboratory of Coal Resources and Safe Mining, China University of Mining & Technology, Beijing 100083, China 2 Department of Mechanical and Manufacturing Engineering, The University of Calgary, 2500 University Drive NW Calgary, AB T2N 1N4, Canada 3 China National Coal Mining Equipment Co. Ltd, Beijing 100011, China 4 Department of Materials and Metallurgy, The University of Utah, Salt Lake City, Utah 84112, USA | 2008 | Science China(Technological Sciences)2008，51，11： | 21 |
| 3 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 4 | The Bedload Movement in the Changjiang Estuary显示文摘- Sandwaves in the Changjiang estuary were measured with a shallow sediment profiler and an echosounder from 1978 to 1988. The data, together with grain size and bedform of sediment indicates that the bedload movement by rolling and saltation is of great significance to sediment transport and is the principal factor responsible for sandwave and sandbody development in the estuary. The sandwaves were found well-developed, which is related to the tidal range and the velocity of ebb current. However, the further growth is restricted by strong flood current prevailing in the estuary. Because of the significant bedload, the sandbodies shift obviously and frequently, and sometimes the exchange of position occurs between the sandbodies and tidal channels. As a result, ships are regularly forced to change their navigation course. | Li Jiufa, Shi Weirong, Shen Huanting Xu Haigen and Doeke Eisma Associate Professor, Institute of Estuarine & Coastal Research (1ECR), East China Normal University, Shanghai200062 Professor, IECR, East China Normal University, Shanghai 200062 Professor, Netherlands Institute for Sea Research, P. O. Box 59 1790 AB, Den Burg, Texel, The Netherlands | 1993 | China Ocean Engineering1993，8，4： | 15 |
| 5 | 巷道注浆加固合理滞后时间的确定显示文摘通过理论分析和试验研究,建立了巷道围岩裂隙系数与巷道轮廓位移量之间的相关关系。介绍了采用注浆锚杆兼作注浆滞后时间指示锚杆的方法和原理,分析了开始注浆时巷道围岩裂隙系数的合理取值范围,给出了确定巷道轮廓位移量的诺模图. | 乔卫国 乌格梁尼采AB 彼尔绅BB | 2003 | 岩石力学与工程学报2003，22，z1： | 13 |
| 6 | 限制性与自由输血策略对心血管疾病患者非心脏手术效果的影响:系统回顾与Meta分析显示文摘目的比较采取限制性与自由输血策略的心血管疾病患者的非心脏手术结局。数据来源搜集涉及医院红细胞输注阈值的随机控制试验。检索CENTRAL、Medline、EMBase、CINAHL、PubMed、LILACS、NHSBT输血证据库、Clinical Trials.gov、WHO国际临床试验注册平台、国际标准随机对照临床试验编号登记、欧盟临床试验登记。检索时间为2015-11-02之前。试验选择选取发表与未发表的比较限制性与自由输血阈值的随机控制试验,试验均纳入心血管疾病患者。结果检索到41项试验,其中7项试验纳入心血管疾病患者。另选取4项纳入心血管疾病患者的试验。最终共搜集11项纳入心血管疾病患者(n=3 033)的试验进行Meta分析(限制性输血1 514例,自由输血1 519例)。输血阈值与30 d死亡率之间联系的汇集风险比例为1.15〔95%CI(0.88,1.50),P=0.50〕,异质性较小(I^2=14%)。限制性输血患者的急性冠脉综合征风险与自由输血患者相比更高〔9项试验;风险比例1.78,95%CI(1.18,2.70),P=0.01,I^2=0%〕。结论对急性冠脉综合征或慢性心血管疾病患者采取80 g/L以下的限制性输血阈值可能并不安全,对病死率与其他结局的影响并不确定。这些数据可暂时支持对急性或慢性心血管疾病患者使用更加自由的输血阈值(>80 g/L),但有待更具有说服力的高质量的心血管疾病患者随机试验进行验证。 | Docherty AB O' Donnell R Brunskill S 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 12 |
| 7 | 概念验证演示:脑控制的肌肉刺激对恢复四肢瘫患者及物及抓握能力显示文摘高位颈脊髓损伤(SCI)患者难以完成日常生活所需的及物和抓握动作。本研究探讨了皮质脑机接口能够充分识别皮质信号以指挥功能性电刺激器(FES)进行手臂运动的能力。受试者是一名53岁的男性,C4,A级的脊髓损伤患者。将两个96通道微电极阵列植入控制手部区域的中央回运动皮层。患者练习一个三维虚拟手臂的运动四个月,然后增加36个经皮肌肉刺激电极于右臂。这些装置用来恢复手指和拇指,手腕,肘和肩的运动。然后对受试者进行皮质指令, | 张长杰 Ajiboye AB Willett FR Young DR | 2017 | 中国康复2017，32，4： | 11 |
| 8 | 外科手术核对清单可全球范围内降低手术并发症发生率和手术死亡率(续前)显示文摘背景外科手术已经成为全球卫生保健构成整体所必需的一部分,估计每年实施的手术有2亿3千4百万次之多,手术并发症常见,并常常是可以预防的。我们设想,通过实施一份19项外科手术安全核对清单,以改善手术团队交流和治疗一致性,将会降低手术并发症发生率和手术死亡率。方法于2007年10月至2008年9月间,从8座城市(加拿大的多伦多、印度的新德里、约旦的安曼、新西兰的奥克兰、菲律宾的马尼拉、坦桑尼亚的伊法卡拉、英国的伦敦、华盛顿州的西雅图市)各选取1所医院共计8所医院参加世界卫生组织的'安全手术拯救生命项目',前瞻性地在临床治疗过程中和治疗结束时收集资料,共有3733例年龄16岁或16岁以上的进行非心脏手术的患者入选,随后在引入'外科手术安全核对清单'后收集了连续入选的3955名患者,主要终点事件为手术后30d内的并发症(包括死亡)发生率。结果在引入核对清单前死亡率为1.5%,手术并发症发生率为11.0%,而引入后死亡率和手术并发症发生率分别下降到0.8%(P=0.003)和7.0%(P<0.001)。结论实施外科手术核对清单可以降低不同医院16岁及16岁以上非心脏手术患者的死亡率和并发症发生率。结果在基线资料收集阶段我们入选了3733名患者,实施核对清单后入选3955名患者。表4罗列了这些患者的情况和医院分布,这两个阶段的患者情况没有明显差别。 | Haynes AB Weiser TG Berry WR 丁一妹 孙永华 高建川 | 2009 | 中华损伤与修复杂志(电子版)2009，4，3： | 9 |
| 9 | Experimental study of dynamic mechanical properties of reactive powder concrete under high-strain-rate impacts显示文摘The dynamic mechanical properties of reactive powder concrete subjected to compressive impacts with high strain rates ranging from 10 to 1.1×102 s-1 were investigated by means of SHPB (split-Hopkinson-pressure-bar) tests of the cylindrical specimens with five different steel fiber volumetric fractions.The properties of wave stress transmission,failure,strength,and energy consumption of RPC with varied fiber volumes and impact strain rates were analyzed.The influences of impact strain rates and fiber volumes on those properties were characterized as well.The general forms of the dynamic stress-strain relationships of RPC were modeled based on the experimental data.The investigations indicate that for the plain RPC the stress response is greater than the strain response,showing strong brittle performance.The RPC with a certain volume of fibers sustains higher strain rate impact and exhibits better deformability as compared with the plain RPC.With a constant fiber fraction,the peak compressive strength,corresponding peak strain and the residual strain of the fiber-reinforced RPC rise by varying amounts when the impact strain rate increases,with the residual strain demonstrating the greatest increment.Elevating the fiber content makes trivial contribution to improving the residual deformability of RPC when the impact strain rate is constant.The tests also show that the fiber content affects the peak compressive strength and the peak deformability of RPC in a different manner.With a constant impact strain rate and the fiber fraction less than 1.75%,the peak compressive strength rises with an increasing fiber volume.The peak compressive strength tends to decrease as the fiber volume exceeds 1.75%.The corresponding peak strain,however,incessantly rises with the increasing fiber volume.The total energy Edisp that RPC consumed during the period from the beginning of impacts to the time of residual strains elevates with the fiber volume increment as long as the fiber fraction is not larger than 2%.It turns to decrease if the fiber volume exceeds 2%.The added fibers make various contributions to enhancing the capability of RPC to consume energy at different loading stages.If the fiber fraction is not larger than 2%,the added fibers make more contribution to enhancing the energy consumption ability of RPC in the period before the peak strain than in the period after the peak strain.The impact strain rate,however,distinctively affects the total energy that RPC consumed and the energy consumed in the different loading periods.The higher the impact strain rate,the more the energy consumed in the stages and therefore the higher the dynamic impact toughness.The empirical relationships of the peak compressive strength,corresponding peak strain,residual strain,total consumed energy and the energy consumed in the varied periods with the impact strain rate and the fiber fraction are derived.Four generalized forms of the dynamic impact stress-strain responses of RPC are formulated by normalizing stresses and strains as the generalized coordinates and by taking account of the influences of impact strain rates and fiber volumetric fractions. | JU Yang1,2,LIU HongBin1,SHENG GuoHua1,3 & WANG HuiJie1 1 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rocks and Concrete,China University of Mining and Technology,Beijing 100083,China 2 Department of Mechanical and Manufacturing Engineering,University of Calgary,2500 University Drive,AB T2N 1N4,Canada 3 School of Resources and Civil Engineering,Northeastern University,Shenyang 110004,China | 2010 | Science China(Technological Sciences)2010，53，9： | 8 |
| 10 | 淋巴细胞与哮喘显示文摘从外周血、支气管肺泡灌洗液及支气管粘膜活检三个方面,较为详尽地综述了近年来有关淋巴细胞参与哮喘发病的最新进展。 | Kay AB 倪殿涛 | 1992 | 国外医学(呼吸系统分册)1992，12，1： | 8 |
| 11 | 中等收入国家年轻人脑卒中发病率增加:基于10年人口的研究显示文摘高收入国家年轻人脑卒中的发病率正在上升。然而,低收入和中等收入国家年轻人的脑卒中发病趋势仍未知。该研究旨在分析2005—2015年在巴西Joinville的年轻人的缺血性脑卒中(isehemic stroke,IS)和脑出血的发病趋势。 | 刘莉 叶鹏 Cabral NL Freire AT Conforto AB Dos Santos N Reis FI Nagel V Guesser VV Safanelli J Longo AL | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 12 | Analysis of the PINK1 gene in a cohort of patients with sporadic earlyonset parkinsonism in Taiwan显示文摘 | Fung HC Chen CM Hardy J Singleton AB Lee-Chen GJ Wu YR | 2006 | 中国生物学文摘2006，20，8： | 6 |
| 13 | Seismic response of tall building considering soil-pile-structure interaction显示文摘The seismic behavior of tall buildings can be greatly affected by non-linear soil-pile interaction during strongearthquakes. In this study a 20-storey building is examined as a typical structure supported on a pile foundation for differentconditions: (1) rigid base, i.e. no deformation in the foundation: (2) linear soil-pile system; and (3) nonlinear soil-pile system.The effects of pile foundation displacements on the behavior of tall building are investigated, and compared with the behavior ofbuildings supported on shallow foundation. With a model of non-reflective boundary between the near field and far field,Novak's method of soil-pile interaction is improved. The computation method for vibration of pile foundations and DYNANcomputer program are introduced comprehensively. A series of dynamic experiments have been done on full-scale piles,including single pile and group, linear vibration and nonlinear vibration, to verify the validity of boundary zone model. | Han Yingcai Fluor Canada Ltd.,Calgary,AB,Canada Ph.D.,Principal Engineering Specialist | 2002 | Earthquake Engineering and Engineering Vibration2002，1，1： | 5 |
| 14 | 一种新型氨甲基环素类药物——omadacycline的体内外药效学显示文摘随着细菌耐药性日益加剧,传统四环素类药物,诸如四环素、多西环素、米诺环素等的临床应用受到了很大的限制。omadacycline是一种新型9-氨甲基环素类药物(PTK0796),为米诺环素基础上进行化学基团修饰后得到的半合成化合物,目前正处于三期临床试验准备阶段。 | Macone AB Caruso BK Leahy RG 傅祝英杰 徐晓刚 | 2014 | 中国感染与化疗杂志2014，14，4： | 5 |
| 15 | 一种使用静态分析和遗传搜索在Android恶意软件检测中搜索最优特征的方法(英文)显示文摘移动设备制造商在全球范围内快速开发各种Android版本。同时,网络罪犯也在实施各种恶意行为,例如跟踪用户活动、窃取个人数据以及实施银行诈骗。由于在日常生活中使用Android进行重要通信的人群数量庞大,这些网络罪犯从中获得了巨大非法收益。为此,安全从业者通过静态和动态分析对恶意软件进行识别。静态分析具有整体代码覆盖、低资源消耗和快速处理的优势。然而,静态分析需要最少量的特征才能对恶意软件进行有效分类。因此,我们采用基于遗传算法(GA)的遗传搜索(GS)在106个字符串中选择特征。为评估由GS确定的最佳特征,我们使用了5种机器学习分类器,分别是Na?ve Bayes(NB)、功能树(FT)、J48、随机森林(RF)和多层感知器(MLP)。在这5种分类器中,FT仅使用6种特征,获得最高准确度(95%)和最高真正率(TPR)(96.7%)。 | Ahmad FIRDAUS Nor Badrul ANUAR Ahmad KARIM Mohd Faizal Ab RAZAK | 2018 | Frontiers of Information Technology & Electronic Engineering2018，19，6： | 5 |
| 16 | 胎儿宫内窘迫与新生儿缺血缺氧性脑病的关系显示文摘胎儿窘迫是产科严重并发症,以胎儿缺氧、酸中毒为主要特征的症候群,可造成新生儿窒息及出生后永久性的神经系统损伤后遗症。对缺氧缺血患儿发生神经系统后遗症的早期预测及基于蛋白质组学的相关生物标记物发现,不但对急性期的诊断有益,而且对高危患儿的管理及早期干预有更深远的意义。本文就胎儿宫内窘迫的诊断、新生儿缺血缺氧性脑病(HIE)预测方法包括胎儿娩出后即取脐动脉血及脐静脉血血气分析了解酸中毒程度,脐静脉血检测促红细胞生成素(EPO), | 吴琴 AB Amoa | 2013 | 检验医学与临床2013，10，22： | 4 |
| 17 | GENETIC PROGRAMMING TO PREDICT SKI-JUMP BUCKET SPILLWAY SCOUR显示文摘Researchers in the past had noticed that application of Artificial Neural Networks (ANN) in place of conventional statistics on the basis of data mining techniques predicts more accurate results in hydraulic predictions. Mostly these works pertained to applications of ANN. Recently, another tool of soft computing, namely, Genetic Programming (GP) has caught the attention of researchers in civil engineering computing. This article examines the usefulness of the GP based approach to predict the relative scour depth downstream of a common type of ski-jump bucket spillway. Actual field measurements were used to develop the GP model. The GP based estimations were found to be equally and more accurate than the ANN based ones, especially, when the underlying cause-effect relationship became more uncertain to model. | AZAMATHULLA H. MD GHANI A. AB ZAKARIA N. A LAI S. H CHANG C. K LEOW C. S ABUHASAN Z | 2008 | Journal of Hydrodynamics2008，20，4： | 4 |
| 18 | Unscrambling light-automatically undoing strong mixing between modes显示文摘Propagation of light beams through scattering or multimode systems may lead to the randomization of the spatial coherence of the light.Although information is not lost,its recovery requires a coherent interferometric reconstruction of the original signals,which have been scrambled into the modes of the scattering system.Here we show that we can automatically unscramble optical beams that have been arbitrarily mixed in a multimode waveguide,undoing the scattering and mixing between the spatial modes through a mesh of silicon photonics tuneable beam splitters.Transparent light detectors integrated in a photonic chip are used to directly monitor the evolution of each mode along the mesh,allowing sequential tuning and adaptive individual feedback control of each beam splitter.The entire mesh self-configures automatically through a progressive tuning algorithm and resets itself after significantly perturbing the mixing,without turning off the beams.We demonstrate information recovery by the simultaneous unscrambling,sorting and tracking of four mixed modes,with residual cross-talk of−20 dB between the beams.Circuit partitioning assisted by transparent detectors enables scalability to meshes with a higher port count and to a higher number of modes without a proportionate increase in the control complexity.The principle of self-configuring and self-resetting in optical systems should be applicable in a wide range of optical applications. | Andrea Annoni Emanuele Guglielmi Marco Carminati Giorgio Ferrari Marco Sampietro David AB Miller Andrea Melloni Francesco Morichetti | 2017 | Light(Science & Applications)2017，6，1： | 4 |
| 19 | β5整合素在造血细胞上的表达和诱导细胞凋亡的作用显示文摘目的 研究整合素 (integrins)αvβ5对造血细胞功能的影响。 方法 用逆转录病毒载体系统将αv、β5基因转染K5 6 2细胞 ,观察αv、β5亚基的表达 ;用去除血清的方法 ,观察造血细胞凋亡和分化时αvβ5和αvβ3的变化 ;用抗αvβ5单抗屏蔽造血细胞上αvβ5时对凋亡和增殖的影响。 结果 将含有 β5基因的逆转录病毒导入K5 6 2细胞 ,β5亚基没有得到表达 ;诱导造血细胞分化和凋亡时 ,αvβ5表达升高 ,而αvβ3表达下降 ;用单抗封闭细胞表面的αvβ5 ,可抑制去血清诱导的细胞凋亡。 结论 造血细胞αvβ5的过度表达可抑制细胞增殖并与细胞凋亡有关。 | 殷莲华 赵新永 付四清 F Garacia-Sanchez AB Deisseroth | 2001 | 中华血液学杂志2001，22，1： | 3 |
| 20 | A comparison of electromigration failure of metal lines with fracture mechanics显示文摘Atoms constructing an interconnecting metal linein a semiconductor device are transported by electron flowin high density.This phenomenon is called electromigration,which may cause the line failure.In order to characterize theelectromigration failure,a comparison study is carried outwith some typical phenomena treated by fracture mechanicsfor thin and large structures.An example of thin structures,which have been treated by fracture mechanics,is silica optical fibers for communication systems.The damage growth ina metal line by electromigration is characterized in comparison with the crack growth in a silica optical fiber subjectedto static fatigue.Also a brief comparison is made betweenthe electromigration failure and some fracture phenomena inlarge structures. | Hiroyuki Abé Mikio Muraoka Kazuhiko Sasagawa Masumi Saka | 2012 | Acta Mechanica Sinica2012，28，3： | 3 |
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