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| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | Autophagy in colorectal cancer:An important switch from physiology to pathology显示文摘Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women worldwide.Among the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant.In recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer.The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent.Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA damage.However,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance.Autophagy studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting results.Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other agents.More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC. | Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea Daniel Constantin Uscatu Mihai Ioana Dan Ionut Gheonea | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 15 |
| 3 | Demons非刚性配准算法拓扑保持性的研究显示文摘在基于配准的图像分割应用中,拓扑保持性是非刚性图像配准算法的一个重要约束.本文从矢量场特性出发,分析了Demons非刚性图像配准算法导致目标拓扑改变时变形场的特点.根据变形场特点与其雅可比行列式之间的关系,给出了校正该算法拓扑保持性的方法.实验表明,改进后的变形场具有了拓扑保持性. | 林相波 邱天爽 阮素 NICOLIER Frédéric | 2010 | 自动化学报2010，36，1： | 12 |
| 4 | The 1470 nm diode laser with an intralesional fiber device:a proposed solution for the treatment of inflamed and infected keloids显示文摘Background:Keloids are the result of abnormal wound healing and often are subject to infections and recurrent inflammation.We present a study conducted with a 1470 nm diode laser using an intralesional optical fiber device for the treatment of inflamed keloid scars.We evaluate its efficacy as a novel alternative method to decrease keloid infection and inflammation.Methods:The patients who underwent 1470 nm laser treatment from February 2016 to February 2018 at the plastic and reconstructive surgery department of the Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University with keloid accompanying serious local infection and fester were included.Patients took curative effect evaluation before and 1 year after the treatment.The test items included infection frequency in each year;pain,by visual analogue scale(VAS);itch,using VAS;quality of life(QOL),using QOL scale;and blood supply,using PeriCam PSI.Results:A total of 19 patients(mean age 35.21 years,range 11–66)with history of inflamed keloids with episodes of infection or abscess were enrolled.Patients underwent to a 1470 nm laser therapy for average of 1.16 times.After treatment,infection frequency and blood supply in keloids were reduced(p<0.001).Pain,itching,and QOL were improved(p<0.001).Conclusion:The present study shows that 1470 nm fiber laser treatment could improve inflamed keloids fairly well by decreasing inflammation,and a relative stabilization of collagen composition.Therefore,it is an effective minimally invasive scar therapy,but further studies are essential to confirm the present results. | Ke Li Fabio Nicoli Wen Jing Xi Zheng Zhang Chunxiao Cui Ahmed Al-Mousawi Alberto Balzani Yun Tong Yixin Zhang | 2019 | Burns & Trauma2019，7，1： | 8 |
| 5 | 急性硬脊膜外自发性血肿13例分析显示文摘目的 探讨和研究急性硬脊膜外自发性血肿的早期诊断和正确治疗。方法 回顾性分析 1985~ 2 0 0 0年法国马塞Timone ,Ste Marguerite医院和上海瑞金医院神经内科 13例急性硬脊膜外自发性血肿患者的临床资料 ,就其病因、发病机制、临床表现、神经影像学检查及治疗与预后 ,结合文献进行分析。结果 13例中 6例诱发因素为凝血功能异常 ;13例起始症状均为神经根性疼痛 ,伴随脊髓压迫症状 ;11例脊髓MRI确诊 ;5例手术治疗有 3例缓解 ;8例保守治疗有 5例缓解。结论 硬脊膜外腔丰富的静脉丛破裂引起无外伤自发性血肿形成 ,典型临床症状结合神经影像学检查能够确诊 ,是急诊手术指征 ,但并非必选治疗方法。本病存在自发性痊愈的特殊类型。 | 曾丽莉 刘振国 沈帆霞 陈生弟 Beatrice DENIS Francois NICOLI | 2002 | 中华神经科杂志2002，35，2： | 5 |
| 6 | Active Demons可变形图像配准算法研究显示文摘在介绍Active Demons可变形图像配准算法的基础上,重点分析该算法中弹性系数σ和均化系数α对配准过程的影响。实验表明,σ和α较小时算法收敛速度快,较大时配准精度高。因此,通过在配准过程中调整二者的值可以实现即快又准的图像配准。 | 林相波 邱天爽 Frédéric Nicolier | 2008 | 中国生物医学工程学报2008，27，4： | 4 |
| 7 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 3 |
| 8 | Exploring the metamorphic consequences of secular change in the siliciclastic compositions of continental margins显示文摘Shale and greywacke compositions from the Archean to Phanerozoic record a secular change in the siliciclastic material that comprises much of Earth's continental margins, past and present. This study explores the metamorphic consequence of these compositional changes, by comparing phase equilibrium models constructed for average Archean, Proterozoic, and Phanerozoic shale and greywacke compositions equilibrated along two Barrovian-type geotherms: 1330℃/GPa(A) and 800 ℃/GPa(B). Our models show that Archean siliciclastic rocks can retain up to 4 vol.% water at middle to lower crustal conditions, nearly twice that of Proterozoic and Phanerozoic compositions. The increased ferromagnesium content of Archean siliciclastic rocks stabilizes chlorite to higher temperatures and results in a biotite-rich assemblage at solidus temperatures. Accordingly, water-absent biotite dehydration melting is predicted to play a greater role in the generation of melt in the metamorphism of Archean aged units,and water-absent muscovite dehydration melting is of increasing importance through the Proterozoic and Phanerozoic. This secular variation in predicted mineral assemblages demonstrates the care with which metamorphic facies diagrams should be applied to Archean compositions. Moreover, secular changes in the composition of shale and greywacke is reflected in the evolution of anatectic melt towards an increasingly less viscous, Ca-rich, and Mg-poor monzogranite. | Gautier Nicoli Brendan Dyck | 2018 | Geoscience Frontiers2018，9，4： | 3 |
| 9 | Stochastic aspects of climatic transitions-response to a periodic forcing显示文摘 | Nicolis C | 1982 | Tellus1982，34，： | 2 |
| 10 | Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Alessandro Valdegamberi Silvia Pachera Tommaso Campagnaro Mirko D'Onofrio Enrico Martone Paola Nicoli Calogero Iacono | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 11 | Self-oscillations and predictability in climate dynamics-periodic forcing and phase locking显示文摘 | Nicolis C | 1984 | Tellus1984，36，： | 2 |
| 12 | Long-term climatic variability and chaotic dynamics显示文摘 | Nicolis C | 1987 | Tellus1987，39，： | 2 |
| 13 | Surgical treatment for liver metastases from colorectal carcinoma:results of 228 patients显示文摘 | Nicoli N Casaril A Mangiante G | | 0，，60： | 1 |
| 14 | Innovative formulations for the delivery of levothyroxine to the skin显示文摘 | Padula C Nicoli S Santi P | | 0，，1： | 1 |
| 15 | Cancer stem cells and 'stemness' genes in neuro- oncology 显示文摘 | Nicolis SK | 2007 | Neurobiol Dis2007，25，2： | 1 |
| 16 | Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector 显示文摘 | Melotti P Nicolis E | 2001 | Gene Ther2001，8，18： | 1 |
| 17 | Outcome of 518 salvage oocyte-cryopreservation cycles performed as a routine procedure in an in vitro fertilization program显示文摘 | LaSala GB Nicoli A ViUani MT | 2006 | Fertil Steril2006，86，5： | 1 |
| 18 | Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3, 5, 4'-trimethoxystilbene 显示文摘 | Belleri M Ribatti D Nicoli S | 2005 | Mol Pharmacol2005，67，5： | 1 |
| 19 | miRNAs in endothelial cell signaling:the endomiRNAs显示文摘 | Santoro MM Nicoli S | | 0，，： | 1 |
| 20 | Enhancement of the Nucleation of Protein Crystals by the Presence of an Intermediate pHase: A Ki-netic Model显示文摘 | Nicolis G Nicolis C | 2003 | Physica A2003，323，： | 1 |
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