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| 1 | Adiponectin,a key adipokine in obesity related liver diseases显示文摘Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin. | Christa Buechler Josef Wanninger Markus Neumeier | 2011 | World Journal of Gastroenterology2011，17，23： | 44 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Frequency domain analysis of the performance of a valved Helmholtz pulse combustor显示文摘 | Neumeier Y Zinn B T Jagoda J I | 1993 | Combustion Science and Technology1993，94，16： | 1 |
| 4 | Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes显示文摘 | Weigert J Neumeier M Wanninger J | 2010 | Clin Endecrinol2010，72，： | 1 |
| 5 | Genomic structure of hum-an omentin,a new adipocytokine expressed in omental adipose tissue显示文摘 | Schaffler A Neumeier M Herfarth H | 2005 | Biochim Biophys Acta2005，1732，13： | 1 |
| 6 | Systemic chemerin is related to inflammation rath- er than obesity in type 2 diabetes显示文摘 | WEIGERT J NEUMEIER M WANNINGER J | 2010 | Clin Endocri- nol2010，72，： | 1 |
| 7 | Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product 'cartonectin'显示文摘 | Sch/fffler A Weigert J Neumeier M | 2007 | Obesity (Silver Spring)2007，15，2： | 1 |
| 8 | The adi- ponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells显示文摘 | Weigert J Neumeier M Schiffler A | 2005 | FEBS letters2005，579，25： | 1 |
| 9 | Ferroelectricity and ferrimagnetism in iron- doped BaTiO3显示文摘 | Maier R Cohn J L Neumeier J J | 2001 | Appl Phys Lett2001，78，17： | 1 |
| 10 | Active instability control effectiveness in a liquid fueled com- bustor显示文摘 | COKER A NEUMEIER Y ZINN B T | 2006 | Combustion Science and Technology2006，178，： | 1 |
| 11 | Character- istics of Microscale Diffusion Flames 显示文摘 | Matta L M Neumeier Y Lemon B Zinn B T | 2002 | Proceedings of the Combustion Institute2002，29，93： | 1 |
| 12 | Plasma levels of leptin,oment-in,collagenous repeat-containing sequence of26-kDa protein(CORS-26)and adiponectin before and after oral glucose uptake in slim adults显示文摘 | Wurm S Neumeier M Weigert J | 2007 | Cardiovasc Diabetol2007，20，6： | 1 |
| 13 | Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26 kD protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults显示文摘 | Wurm S Neumeier M Weigert J | 2007 | Cardiovasc Dialoetol2007，6，： | 1 |
| 14 | The adiponec- tin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytie cells 显示文摘 | Weigert J Neumeier M Schfler A | 2005 | FEBS Lett2005，579，25： | 1 |
| 15 | Elevated free fatty acids and impaired adiponectin bioactivity contribute to reduced SOD2 protein in monocytes of type 2 diabetes patients显示文摘 | Bauer S Wanninger J Neumeier M | 2011 | Exp Mol Pathol2011，90，： | 1 |
| 16 | The influence of vegetation on turbulence and flow velocities in European salt-marshes 显示文摘 | NEUMEIER U AMOS C L | 2006 | Sedimentology2006，53，2： | 1 |
| 17 | Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn's disease显示文摘 | Weigert J Obermeier F Neumeier M | 2010 | Inflamm Bowel Dis2010，16，4： | 1 |
| 18 | Scr Mater显示文摘 | Bauer A Neumeier S Pyczak F | 2010 | 63: 11972010，63，： | 1 |
| 19 | Genomie structure of human Omenfin, a new adipoeytokine ex- pressed in omental adipose tissue 显示文摘 | SCHAFFLER A NEUMEIER M HERFARTH H | 2005 | Biochimiea et Biophysiea Aeta (BBA) -Gene Strueture and Expression2005，1732，1： | 1 |
| 20 | Detection of adiponectin in cerebrospinal fluid in humans 显示文摘 | Neumeier M Weigert J Buettner R | 2007 | Am J Physiol Endocrinol Metab2007，293，4： | 1 |
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