|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Discovery of laryngeal carcinoma by serum proteomic pattern analysis显示文摘Laryngeal carcinoma is the most common malignancy among head and neck tu-mors. The purpose of this study is to find biomarkers for laryngeal carcinoma in patient blood serum using the Surface Enhanced Laser Desorption/Ionization (SELDI) technique. Serum samples from 33 laryngeal carcinoma (12 cases of glottis, 18 of supraglottis and 3 of subglottis) patients and 31 age- and sex-matched healthy people were analyzed by SELDI-TOF on a Pro-teinChip reader, PBSII-C. Protein profiles were generated using WCX2 protein chips. Protein peak clustering and classification analyses were performed utilizing the Biomarker Wizard and Biomarker Pattern software packages, respectively. The results showed that sixteen peaks had significant difference between laryngeal cancer patients and healthy group, eight of which were up-regulated in the patient samples, and the others were down-regulated. Two protein peaks 8153 Da and 2035 Da were automatically chosen for the system training and development of a classification tree. The analysis yielded a correct percentage of 96.9% for patients and 96.7% for control. The results suggest that serum is a useful resource for the detection of specific bio-markers for laryngeal carcinoma. Proteinchip Array System was a useful tool for a high throughput screening of large-sized serum samples to discover potential biomarkers for carci-noma. | XIAO Xueyuan1, ZHAO Xiaodong2, LIU Jiankai3, GUO Fuzheng1, LIU Danhui1 & HE Dacheng1 1. Key Laboratory for Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Universities?Confeder-ated Institute of Proteomics, Beijing 100875, China 2. Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital, Jilin University, Changchun 130031, China 3. Department of Biochemistry, Jilin University, Changchun 130021, China | 2004 | Science China(Life Sciences)2004，47，3： | 22 |
| 2 | 血管内皮生长因子-C、-D与肿瘤淋巴道转移研究进展显示文摘恶性肿瘤淋巴道转移的机制和抗肿瘤淋巴道转移的治疗是目前的研究热点之一,不少研究表明血管内皮生长因子-C(vascularendothelialgrowthfactor-C,VEGF-C)和血管内皮生长因子-D(VEGF-D)与恶性肿瘤的淋巴道转移密切相关。本文主要综述VEGF-C、VEGF-D的结构、功能特点、在肿瘤淋巴道转移中的可能机制及由此而引发出的抗肿瘤淋巴道转移治疗的有关进展。 | LI Qiu li, CHEN Fu jingDepartment of Head &Neck,Cancer Center,Sun Yat sen University,Guangzhou 510060,P.R.China | 2002 | 癌症2002，21，6： | 22 |
| 3 | Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for head and neck cancer 2018 (English version)显示文摘Contents1. Principles of diagnosis and treatment of head and neck cancer2. Diagnosis principles of head and neck cancer2.1 Image diagnosis2.2 Pathological diagnosis2.3 Staging3. Treatment principles of early and locally advanced head and neck squamous cell carcinoma3.1 Treatment of oral cancer3.1.1 Treatment of early oral cancer3.1.2 Treatment of locally advanced oral cancer. | Pingzhang Tang Ye Guo Chaosu Hu Zhengang Xu Chenping Zhang Liang Zhou | 2019 | Chinese Journal of Cancer Research2019，31，1： | 15 |
| 4 | Anatomic structural study of cerebellopontine angle via endoscope显示文摘在颅骨底依靠寻找内视镜的技术的可能的解剖基础的背景最低限度地侵略的外科是争论的。这研究的目的是在 cerebellopontine 角度区域观察在主要的血容器和神经之间的空间关系并且为侧面、以后的颅骨底提供解剖基础经由内视镜的 retrosigmoid 锁眼 approach.Methods 的最低限度地侵略的外科这研究在三十个弄干的成年颅骨上被进行测量空间关系在之中出现以后的头部的窝的多骨的标记,并且为 retrosigmoid 锁眼 ap 定位最适当的钻区域在直径与 2.0 厘米在这个点上集中的一个洞对在 cerebellopontine 角度暴露相关结构合适。 Retrosigmoid 锁眼途径罐头减少小脑上的压力并且有效地暴露相关结构它包括面部神经, vestibulocochlear 神经,三叉的神经,舌与喉的神经,迷走神经神经,附件神经,舌下神经神经,前面的劣等的小脑的动脉,以后的劣等的小脑的动脉和迷宫的动脉,内诊镜 retrosigmoid 途径上的准确地点能避免在最低限度地侵略的外科期间拖小脑的 etc.Conclusions 。retrosigmoid 锁眼途径的申请将扩大内视镜的技术的申请。 | XIA Yin LI Xi-ping HAN De-min ZHENG Jun LONG Hai-shan SHI Jin-feng Department of Otolaryngology,Beijing Tongren Hospital,Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing 100730,China (Xia Y,Li XP,Han DM,Zheng J,Long HS and Shi JF) | 2007 | Chinese Medical Journal2007，，20： | 7 |
| 5 | Adenoviral-mediated Hath1-EGFP gene transfer into guinea pig cochlea through intact round window membrane显示文摘Objective To study expression of adenoviral-mediated Hath1-EGFP gene in the guinea pig cochlea after transfer through intact round window membrane(RWM), and to assess its effects on hearing. Methods Twenty adult guinea pigs were used, of which: 12 were surgically inoculated with Ad-Hath1-EGFP in the bony groove of round window niche, and 8 with artificial perilymph. Auditory brainstem response(ABR) thresholds were determined in all animals before and 5 days after surgery. On post-surgery day 5 and day 14, animals were sacrificed and whole mounts of cochlea and frozen sections were examined. Results ABR tests showed no significant change of hearing after the surgery. Strong fluorescence staining in the cochleae was seen in Ad-Hath1-EGFP groups. The highest levels of gene expression were seen in the post-surgery day 5 group with little decrease on post-surgery day 14.The contralateral cochlea and those in the control groups were free of fluorescence staining. Conclusion The transgenic Hath1-EGFP can be effectively delivered into the inner ear through intact RWM, in an atraumatic manner. | CHEN Wei1☆, HU Yin-yan1☆, YANG Shi-ming1*, GUO Wei1, SUN Jian-he1, HAN Dong-yi1, ZHAI Suo-qiang1, YANG Wei-yan1, David Z.Z.He2 1. Neurologic Biological centre, Institute of Otolaryngology, Department of Otorhinolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing 100853, China 2. Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA | 2008 | Journal of Otology2008，3，1： | 7 |
| 6 | Hearing and Cochlear structures in a Swine Model显示文摘Objective To study the audition and inner ear structure in a normal swine model.Methods Auditory brainstem responses(ABRs) were determined in swine at 1 day and 1 month after birth.The form of the cochlea and hair cells were examined under a scanning electron microscope and on cochlear slices.Results ABR thresholds at 1 day and 1 month post-birth were between 40 and 50 dB SPL.The latencies of waves I,III and V in 1 day old swine were 1.97 ± 0.13,3.01± 0.16 and 4.26±0.20 ms,respectively.At 1 month,the lantancies of waves I,III and V were 2.01 ± 0.05,3.11±0.08 and 4.65 ± 0.14 ms,respectively,slightly longer than those at 1 day,although not statistically significant(p>0.05).The swine cochlea was constituted of 3 and a half turns and the cochlear hair cells lined up in four rows.Hair cell cilia in the apical turn were longer than those in other turns.Conclusions The swine cochlea is mature at the time of birth.Swine ABR thresholds are slightly higher than humans and rats.Swine appears to be a precocial animal species. | GUO Wei-wei1,Cheng Lei2,Liu Hui-zhan1,Sun Jian-he1,YANG Shi-ming1,1 Department of Otolaryngology,Head & Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,China 2 State Rey laboratory for Agrobio technology China Agrical universiy Beijing 100193,PR,China | 2010 | Journal of Otology2010，5，2： | 7 |
| 7 | Backward Propagation of Otoacoustic Emissions显示文摘Normal mammalian ears not only detect but also generate sounds. The ear-generated sounds, i.e., otoacoustic emissions (OAEs), can be measured in the external ear canal using a tiny sensitive microphone. In spite of wide applications of OAEs in diagnosis of hearing disorders and in studies of cochlear functions, the question of how the cochlea emits sounds remains unclear. The current dominating theory is that the OAE reaches the cochlear base through a backward traveling wave. However, recently published works, including experimental data on the spatial pattern of basilar membrane vibrations at the emission frequency, demonstrated only forward traveling waves and no signs of backward traveling waves. These new findings indicate that the cochlea emits sounds through cochlear fluids as compression waves rather than through the basilar membrane as backward traveling waves. This article reviews different mechanisms of the backward propagation of OAEs and summarizes recent experimental results. | HE Wenxuan,1, 2 REN Tianying,1, 21. Oregon Hearing Research Center, Department of Otolaryngology and Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, Oregon 97239 USA 2. School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061 China | 2006 | Journal of Otology2006，1，1： | 4 |
| 8 | Development of a script of phonemically balanced monosyllable lists of Mandarin-Chinese显示文摘Objectives To develop a set of monosyllable audiometry test material that can be used in speech recognition testing in Mandarin Chinese. Materials and Methods In an effort to improve reliability and efficiency in clinical practice, a set of 30 test lists of 25 monosyllable test items each was designed with consideration of the following: length of the list, phonemical balance (PB), word utility frequency, coverage of common words, and equivalency among lists. The 30 lists contained 750 monosyllabic words and were constructed on the basis of Chinese phoneme distribution probability summarized in the Manual of Acoustic. The occurrence incidence of the 22 consonants, 36 vowels, and 4 tones of the Chinese Mandarin characters in the 30 test lists were calculated. To achieve PB, 489 monosyllables were selected from the 2500 most commonly used Chinese characters and the 4000 most commonly used Chinese phrases to compile the 30 monosyllable test lists using a computer algorithm with manual adjustment. Results Thirty phonemical balanced word lists of common Mandarin Chinese monosyllabic words were compiled. Each list consisted of 25 monosyllables. A total of 489 phonemes (consonants, vowels and tones) were included in the set. Conclusions This set of lists can potentially be used as the basic lists for future development of Mandarin PB monosyllable speech test materials. | JI Fei, CHEN Aiting, ZHAO Yang, XI Xin, HAN Dongyi Departments of Otorhinolaryngology-Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of People’s Liberation Army, Beijing 100853, China | 2010 | Journal of Otology2010，5，1： | 4 |
| 9 | Cochlear implantation in a child with auditory neuropathy spectrum disorder显示文摘Objective To report outcomes of cochlear implantation (CI) in a child with auditory neuropathy spectrum disorder (ANSD) and to provide preliminary clinical evidence of the efficacy of CI in ANSD patients.Methods A 4-year-old boy with diagnosed auditory neuropathy spectrum disorder (ANSD) received implantation of a Nucleus CI24R after an unsatisfactory trial of amplification.Post-implantation performance in both hearing sensitivity and speech recognition was assessed in different sessions.Aided hearing thresholds were tested by behavioral audiometry.Mandarin Early Speech Perception Test (MESP),Meaningful Auditory Integration Scale (MAIS),category of auditory performance (CAP) and Speech Intelligibility Rating (SIR) were used to assess the benefits in auditory skills or speech recognition the boy obtained from CI.The tests were administered before surgery and at 3 months and 7 months after opening.Results The boy demonstrated improved auditory sensitivity by using CI.Concerning speech recognition and communication,both speech audiometry and questionnaires showed an obvious benefit from CI.Conclusions CI has worked efficiently in this ANSD boy.But because of limited understanding of ANSD and rehabilitation effect by cochlear implantation in this condition,the clinical decision to implant should be cautious and only after a thorough evaluation.Meanwhile,well controlled and long term studies are needed to confirm the efficacy of cochlear implantation in patients with ANSD. | JI Fei CHEN Ai-ting HONG Meng-di SHI Wei LI Jia-nan YANG Shi-ming Department of Otolaryngology/Head and Neck Surgery,Chinese PLA Institute of Otolaryngology,Chinese PLA General Hospital,28 Fuxing Road,Beijing 100853,China | 2011 | Journal of Otology2011，6，2： | 4 |
| 10 | Hearing Preservation in Acoustic Neuroma Surgery显示文摘Objective To report the authors’ experiences in hearing preservation during acoustic neuroma (AN) resection procedures. Methods Two cases of AN removal via retrosigmoid approach were reviewed. Hearing preservation was attempted in the aid of endoscopic technique along with continuous monitoring of the compound action potential (CAP) and auditory brainstem response(ABR) during the surgery. Results The tumor in Case 1 was 1.5 cm in diameter. The average pure-tone hearing threshold was 30 dB HL and ABR was normal. Waves I, III and V of ABR were present following tumor removal. At 7th month follow-up, audiometric thresholds and ABR inter-peak intervals had recovered to pre-operative levels, with normal facial nerve function. The patient in Case 2 had bilateral AN. The tumors measured 4.0 cm(left) and 5.0 cm (right) on MRI scans. The AN on the right side was removed first, followed by removal of the left AN four months later. Intraoperative CAP monitoring was employed during removal of the left AN. While efforts to preserve the cochlear nerve were not successful, CAPs were still present after tumor removal. Conclusions Intraoperatively recorded CAPs are not reliable in predicting postoperative hearing outcomes. In contrast, ABRs are an indicator of function of the peripheral auditory pathway. Presence of waves I, III and V following tumor removal may represent preservation of useful hearing. | HAN Dongyi, YU Limei, YANG Shiming, YU LimingDepartment of Otolaryngology-Head and Neck Surgery, PLA General Hospital, Beijing 100853 | 2006 | Journal of Otology2006，1，1： | 4 |
| 11 | Prevalence of the GJB2 Mutations in Deafness Patients of Different Ethnic Origins in Xinjiang显示文摘Objective To investigate GJB2 mutation prevalences in the Uigur and Han ethnic groups in Xinjiang, China, and determine the relationship between ethnicity and GJB2 gene mutations. Methods Information regarding ethnicity of patients' families was obtained through medical records review and/or patient interview. Blood samples were collected from 61 Uigurs and 66 Hans for direct sequencing of the coding region and intron/exon boundaries of the GBJ2 gene. Results Carrier frequency of GJB2 mutations was similar between the Uigur and Han subjects. The GJB2 35delG mutation was seen only in Uigur patients with hearing loss, whereas the 235delC mutation was identified in both Uigur and Han patients. The allelic Frequency of 35delG mutation was 7.4% (9/122) in Uigur deaf students, but none in Han deaf students (0/128) and Uigur controls (0/196). The allelic frequency of GJB2 235delC mutation in Uigur and Han deaf students was 5.7% and 9.8%, and that of 299-300delAT mutation was 0.8% and 5.5%, respectively. V27I and E114G were the most frequent types of polymorphism. Conclusion We found an Asian-specific GJB2 diversity among Uigurs, and comparable GJB2 contribution to deafness in Uigur and Han patients. The high carrier frequency of 35delG in Uigurs (11.5%) is probably defined by gene drift/founder effect in a particular group. Even though GJB2 mutations have been widely reported in the literature, this discussion represents the first report of GJB2 mutations in Chinese multi-ethnic populations. | LI Qi1, DAI Pu1, HUANG De-liang1, ZHANG Jin2, WANG Guo-jian1, ZHU Qing-wen1, Liu Xin3, HAN Dong-yi1 1 Department of otolaryngology Head & Neck Surgery/Institute of Otorhinolaryngology, Genetic Testing Genter for Deafness, PLA General Hospital, Beijing 100853 2 Department of otolaryngology Head & Neck Surgery, Xinjiang Uigur Municipality People’s Hospital 3 Department of otolaryngology Head & Neck Surgery, PLA sixteenth Hospital | 2007 | Journal of Otology2007，2，1： | 3 |
| 12 | 甲状腺乳头状腺癌颈淋巴结清扫术显示文摘我院在1952~1997年共治疗甲状腺癌2097例,其中乳头状腺癌1732例1954~1992年间乳头状腺癌1219例,男317,女902例,男女之比为1:2.85.年龄最小6岁,最大80岁,中位年龄37.68岁,S=12.72,行颈淋巴结清除术913例(71例行双颈清除术),共984例次。通过对913例(984例次)颈淋巴结清除术的分析及随访。预防性组淋巴结阳性率为66.32%,治疗性组为93.98%,预防性组10年以上无瘤生存率远高于治疗性组。治疗性组5年、10年无瘤生存率功能性组优于传统性组(P<0.01),预防性组10、15、20年无瘤生存率功能性组优于传统性组(P<0.005),说明功能性颈淋巴结清除术即保留功能又不降低生存率,是一种值得提倡的治疗方法。另外通过109例死亡原因回顾,死于复发和转移62例(56.88%),术后10年内死亡者占83.87%(52/62),术后10年以上复发机会明显减少。转移瘤多以肺转移为主,占71.4%。 | 徐本义 高明 张艳 张学忠 姜辉春. 72) . Most (913) of the patients were undergone neck dissection. 71 of the 913 patients underwent a bilateral nec | 1998 | 中国耳鼻咽喉头颈外科1998，9，S1： | 3 |
| 13 | Reduction of neural adhesions by biodegradable autocrossiinked hyaluronic acid gel after injury of peripheral nerves: an experimental study 显示文摘 | Smit X van Neck JW Afoke A | 2004 | Journalof neurosurgery2004，101，4： | 1 |
| 14 | Predicting smear negative pulmonary tuberculosis with classification trees and logistic regression: a cross-sectional study 显示文摘 | Fernanda Carvalho de Queiroz Mello Luiz Gustavo do Valle Bastos Sergio Luiz Machado Soares Valeria MC Rezende Marcus Barreto Conde Richard E Chaisson Afranio Lineu Kritski Antonio Ruffino Netto Guilherme Looreiro Wet neck | 2006 | BMC Public Health2006，23，6： | 1 |
| 15 | EORTC Early Clinical Trials Group显示文摘 | Catimel G Verweij J Mattijssen V Docetaxel (Taxotere):an active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck | 1994 | Ann Oncol1994，5，： | 1 |
| 16 | High-reso-lution ultrasonography of the cutaneous nerve branches inthe hand and wrist 显示文摘 | Stokvis A Van Neck JW Van Dijke CF | 2009 | J Hand Surg Eur Vol2009，34，6： | 1 |
| 17 | Otitis media with effusion 显示文摘 | American Academy of Family Physicians American Academy of Otolaryngology-Head Neck Surgery American Academy of Pediatrics | 2004 | Pediatrics2004，113，5： | 1 |
| 18 | Incidence and survival trends based on 1973- 2007 surveillance,epidemiology,and end results data显示文摘 | Ellington CL Goodman M Kono SA Adenoid cystic carcinoma of the head and neck | 2012 | Cancer2012，，： | 1 |
| 19 | A randomized, controlled trial 显示文摘 | Tidemark J Ponzer S Svenson O Internal fixation compaired with total hip replacement for displaced femoral neck fractures in the elderly | 2003 | J Bone Joint Surg (Br)2003，85，： | 1 |
| 20 | Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart显示文摘 | Ravingerová T Matejíková J Neckár J | 2007 | Mol Cell Biochem2007，297，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员