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| 1 | The effect of folic acid on the development of stomach and other gastrointestinal cancers显示文摘Objective To evaluate the roles of folic acid and β-carotene in the chemoprevention of gastric and other gastrointestinal (GI) cancers. Methods In a randomized, double-blind, placebo-controlled trial, a total of 216 patients with atrophic gastritis were randomly assigned to one of the four groups: ①folate (FA, 20 mg per day plus vitamin B 12 1 mg, intramuscularly, per month for one year, then 20 mg two times a week plus 1 mg per three months for the next year); ②natural β-carotene (N-βC, 30 mg per day for first year, then 30mg two times a week for the next); ③synthetic β-carotene (S-βC, administered as in N-βC); and ④placebo. Follow-ups continued from 1994 to 2001. Results A total of 7 new cases of gastrointestinal cancers were diagnosed with 3 stomach, 1 colon and 1 esophageal cancers occurring in the placebo group; 1 stomach cancer in both of the N-βC and S-βC groups, and no cancer occurring in FA group. In terms of GI cancers, there was a significant reduction in the FA group, compared with the placebo group (P= 0.04). A similar trend was observed in both N-βC and S-βC groups (P=0.07-0.08). Taken together, the three intervention groups displayed a highly significant decrease in occurrence (P=0.004, vs placebo), and a lower risk for GI cancers (OR=0.12; 95% confidence interval, 0.03-0.51). For development of gastric cancer, any one of the three active-treated groups did not reach statistically significant reduction. The FA group showed obvious improvement of the gastric mucosal lesions with more patients displaying lesions reversed or stable atrophy and inflammation (P=0.04), reversed intestinal metaplasia (P=0.06) at the end of follow-up, and reversed displasia (P=0.017) at 12 months. Two cases of false jaundice were found in β-carotene groups with no influence on administration, and no side-effects were reported in FA group. Conclusions This trial revealed the interventional effect of folic acid on the development of GI cancers, a similar effect of β-carotene was also detected. Also, folic acid may be of use to treat atrophic gastritis by preventing or reversing the precancerous lesions. | 朱舜时 施尧 胡运彪 李蓉蓉 汪敏 周怡和 金冠球 谢宇野Shanghai Navy Hospital Shanghai 200081 China 邬桂泉 夏德凰Shanghai Putuo People's Hospital 钱珍华 宋海连Shanghai Traditional and Western Medical Integrated Hospital 屠伯强 张丽冬 萧树东 | 2003 | Chinese Medical Journal2003，，1： | 42 |
| 2 | Prognostic factors in the surgical treatment of caudate lobe hepatocellular carcinoma显示文摘AIM:To evaluate the short-and long-term outcomes of liver resection for caudate lobe hepatocellular carcinoma (HCC).METHODS:We retrospectively analyzed 114 consecutive patients with HCC,originating from the caudate lobe,who underwent resection between January 2001 and January 2007.Univariate and multivariate analyses were performed on several clinicopathologic variables to determine the factors affecting long-term outcome and intrahepatic recurrence.RESULTS:Overall mortality and morbidity were 0% and 18%,respectively.After a median follow-up of 31 mo (interquartile range,11-66 mo),tumor recurrence had occurred in 76 patients (66.7%).The 1-,3-,and 5-year disease-free survival rates were 65.7%,38.1%,and 18.4%,respectively.The 1-,3-,and 5-year overall survival rates were 76.1%,54.7%,and 31.8%,respectively.Univariate analysis showed that subsegmental location of the tumor (45.7% vs 16.2%,P=0.01),liver cirrhosis (12.3% vs 47.9%,P=0.03),surgical margin (18.5% vs 54.6%,P=0.04),vascular invasion (37.9% vs 23.2%,P=0.04) and extended caudate resection (42.1% vs 15.4%,P=0.04) were related to poorer long-term survival.Multivariate analysis showed that only subsegmental location of the tumor,liver cirrhosis and surgical margin were significant independent prognostic factors.CONCLUSION:Hepatectomy was an effective treatment for HCC in the caudate lobe.The subsegmental location of the tumor,liver cirrhosis and surgical margin affected long-term survival. | Peng Liu,Jia-Mei Yang,Wen-Yang Niu,Tong Kan,Feng Xie,Dian-Qi Li,Ye Wang,Yan-Ming Zhou,Department of Special Treatment and Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Peng Liu,Department of Hepatobiliary Surgery,Navy General Hospital,Beijing 100037,China | 2010 | World Journal of Gastroenterology2010，16，9： | 15 |
| 3 | Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation显示文摘AIM: To evaluate the immunologic role and expressionsignificances of nitric oxide(NO), nitric oxide synthase(NOS),and its isoenzyme in acute rejection to liverxenografts from golden hamster in rat.METHODS: Liver transplantations were randomlydivided into five groups(n=6-9):isografts (group I );xenografts (groupⅡ); xenografts plus cyclosporinetreatment (group Ⅲ), xenografts pluscyclophosphamide treatment combined withsplenectomy (group Ⅳ), and xenografts usingcyclophosphamide in combination with splenectomy(group Ⅳ) and xenografts using splenectomy inaddition to cyclophosphamide and cyclosporinetreatments(group V) .The levels of ALT, TNF- α, andnitric oxide production(NOx) in serum of reciprentswere examined,and expressions of type Ⅱ (iNOS) andtypeⅢ (cNOS) nitric oxide synthase(NOS)-inducibleNOS(iNOS) and constitutive NOS(cNOS) wereobserved by NADPH diaphorase histochemical andimmunohistochemical staining.RESULTS: The level of serum ALT, activity of serumTNF-α and systemic levels of NO metabolite in groupsⅡand Ⅳ were higher than those of groups Ⅰ andy(serum ALT, 2416±475, 2540±82.5) nkat. L-1 vs(556.8±43.5, 677.30±38.2 ) nkat. L-1, P<0.01;(serum TNF-α, 353.5±16.1,444.6±28.1) ng.L-1 vs38.5±5.2, 52.0±5.7) ng.L-1, P<0.01; (serum NOx514.6 ± 18.1, 336.0 ± 43.0 )nmol.g-1, vs 26.1 ± 5.7, 27.7±6.0) nmol.g-1, P<0.01.Cyclosporine in group Ⅲcan repress the cellular immune response and thesynthesis of nitric oxide and the expression of NOsynthase,but not prolong the liver xenograftsurvival.The over-expression of NOS, iNOS and cNOSin liver xenograft rejection in groups Ⅱand Ⅳ weredetected by NADPH diaphorase histochemical andimmunohistochemical staining.CONCLUSION: The degrees of acute rejection can beeffectively repressed in golden hamster to rat liverxenografts with splenectomy and cyclosporine. Nitricoxide metabolites, and nitric oxide synthase and itsisoenzymes,above all inducible NOS (iNOS) can beused as potential diagnostic markers for acuterejection in liver transplantation. The cellularlocalization of nitric oxide varies according to theimmunologic status of liver xenografts, thus thinkingthat hepatocyte derived nitric oxide may be protectivein the hyporesponsive state, but hepatic injury is likelytriggered by centrilobular iNOS expression in thesuperresponsive state. | Tong-Jin Diao Tong-Ye Yuan You-Lin Li Department of General Surgery and Hepatobiliary Surgery,the Chinese PLA Navy 401 Hospital Qingdao 266071,China | 2002 | World Journal of Gastroenterology2002，8，4： | 10 |
| 4 | Effect of Lanthanum Accumulation on Cation Exchange Capacity and Solution Composition of Red Soil显示文摘Pot and adsorption-exchange experiments were carried out by collecting the soil samples from the surface layer(0-15cm) of red soil at the Ecological Experiment Station of Red Soil,the Chinese Academy of Sciences,in Jiangxi Province of CHina.When concentration of the exogenous La^3+ exceeded 400mg kg^-1,there was less non-exchangeable La^3+ than exchangeable La^3+ in the soil.Cation exchagne capacity of the soil changed slightly with increasing concentration of the exogenous La^3+ in both experiments.However,in the adsorption-exchange experiment,when concentration of the exogenous La^3+ was higher than 300mg kg^-1,exchangeable basic cations decreased significantly,while exchangeable hydrogen and exchangeable aluminum increased significantly compared with the control treatments.The amounts of base cations(Ca^2+,Mg^2+,k^+and Na^+)exchanged by La^3+ in the supernatant solution increased with the concentration of the exogenous La^3+,especially when concentration of the exogenous La^3+ was higher than 50mg kg^-1. | XIE ZUBIN ZHU JIANGUO CHU HAIYAN CAO ZHIHONG and DENG XIHAI(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naviing 210008 China) | 2000 | Pedosphere2000，10，2： | 6 |
| 5 | 大豆叶部病害研究的简易离体叶片培养技术显示文摘为寻找简易有效的大豆叶部病害研究方法,利用大豆离体叶片,进行了相关试验。试验结果表明,大豆离体复叶培养30 d,新根长达16.8~41.2 cm,平均根长国>24 cm,移至营养杯30 d后,叶色及叶片仍保持完好。经离体叶片法和整株法接种大豆锈病病原菌后,不同品种和不同菌株表达出不同的病斑反应型;接种大豆白粉病病原菌,也同样表达出在不同品种和不同接种浓度条件下,大豆白粉病发生程度不同;两种接种方试验结果一致。本方法试验条件可控、易控,省时,省空间,因此可考虑应用于大豆叶部病害研究的各种试验。 | 莫贱友 郭堂勋 Navi S S 李讯 杨小冰 | 2007 | 大豆科学2007，26，5： | 5 |
| 6 | Design of secure operating systems with high security levels显示文摘Numerous Internet security incidents have shown that support from secure operating systems is paramount to fighting threats posed by modern computing environments. Based on the requirements of the relevant national and international standards and criteria, in combination with our experience in the design and development of the ANSHENG v4.0 secure operating system with high security level (hereafter simply referred to as ANSHENG OS), this paper addresses the following key issues in the design of secure operating systems with high security levels: se- curity architecture, security policy models, and covert channel analysis. The design principles of security architecture and three basic security models: confidentiality, integrity, and privilege control models are discussed, respectively. Three novel security models and new security architecture are proposed. The prominent features of these proposals, as well as their applications to the ANSHENG OS, are elaborated. Cover channel analysis (CCA) is a well-known hard problem in the design of secure operating systems with high security levels since to date it lacks a sound theoretical basis and systematic analysis approach. In order to resolve the fundamental difficulties of CCA, we have set up a sound theoretical basis for completeness of covert channel identification and have proposed a unified framework for covert channel identification and an efficient backward tracking search method. The successful application of our new proposals to the ANSHENG OS has shown that it can help ease and speedup the entire CCA process. | QING SiHan1,2 & SHEN ChangXiang3 1 Institute of Software, Chinese Academy of Sciences, Beijing 100080, China 2 School of Software and Microelectronics, Peking University, Beijing 102600, China 3 Institute of Computing Technology, Navy, Beijing 100841, China | 2007 | Science in China(Series F)2007，50，3： | 5 |
| 7 | Effects of L-arginine during ischemia-reperfusion injury in rat orthotopic liver transplantation显示文摘EfectsofLarginineduringischemiareperfusioninjuryinratorthotopiclivertransplantationDIAOTongJin1,YAOXiaoPing2,JIBing1,YANG... | DIAO Tong Jin 1, YAO Xiao Ping 2, JI Bing 1, YANG Jia Mei 2, WU Meng Chao 2 and ZHANG Shao Geng 3 1Department of General Surgery, Chinese PLA 401 Navy Hospital, Qingdao 266071, Shandong Province, China 2Eastern Hospital of Hepa | 1998 | World Journal of Gastroenterology1998，4，3： | 4 |
| 8 | Infection associated with hydroxyapatite prosthesis and related factors显示文摘Background The purpose of otomicrosurgery in modern times is to achieve complete removal of disease, which is the basis for hearing rehabilitation. Artificial ossicles are important for hearing rehabilitation. One of the materials is hydroxyapatite that acts as ossicular replacement prosthesis (HA prosthesis, PORP & TORP) and is commonly used as substitute bone in clinics. Although HA prostheses feature good biocompatibility, stability and certain resistance to infection, the structure of the material can be decomposed and absorbed. Based upon animal experiments and clinical application, this article explores the infectivity of HA prostheses and influencing factors. Materials and Methods HA prostheses were implanted in the bulla in guinea pigs. Infected HA prostheses were examined under a scanning electron microscope. Ninety patients implanted with HA prostheses were followed for more than 3 months. Five cases that had undergone revision operations were reported. Results Scanning electronic microscopy showed that the normal compact structures had disappeared and become loose in infected HA prostheses, with their micropores infiltrated with effusion, fibrous tissue and inflammatory cells. As a result, the normal ceramic structure was decomposed and the micropores structure disappeared. The infected mesotympanum in the reported cases also led to HA infection. The shape and structure of bone were destroyed, which was visible by visual examination and light microscopy. The process of cholesteatoma recurrence was always associated with infection, although the HA prosthesis was sometimes spared. Conclusion While HA prosthesis is anti-infective to some extent, long-term infection and cholesteatoma recurrence can lead to destruction and decomposition of HA prostheses. Long-term infected middle ear cavity, dysfunctional Eustachian tube, residual and recurrent cholesteatoma and other factors can cause decomposition of HA prosthesis and result in hearing loss. | LIU Yang SUN Jian-jun Center of Otolaryngology of PLA, Navy General Hospital, Beijing 100037, China | 2010 | Journal of Otology2010，5，1： | 3 |
| 9 | Degradation of Soil Nutrients in Southeast China显示文摘A total of 2 190 soil nutrient data in the Second National Soil Survey of China were collected to assess thedegradation of soil nutrients in the hilly region of Southeast China. The definition of soil nutrient degradationis suggested firstly then the evaluation criteria are set up and the current status of degradation of red soil and latosol is assessed. The percentages of areas in four grades of soil nutrient degradation, i.e., slightlydeficient, medium deficient, severely deficient and extremely deficient, were 21.3%, 43.3%, 16.2% and 3.0%for soil total N; 0.7%, 6.4%, 16.7% and 76.2% for soil available P; and 25.4%, 26.3%, 8.6% and 5.0% forsoil available K, respectively. The severity of soil nutrient degradation was in the order of P > N > K. Themajor factors leading to the degradation of soil nutrients in quantity include soil erosion, leaching and theconsumption by crops. And the principal faCtor affecting the degradation of soil nutrieots in availability isthe fixation of N, P and K, especially the fixation of phosphorus. The average amouat of P fixed by soils is408 mg kg-1, and upland soils can fix more P than paddy soils. | LU RUKUN SHI ZHENGYUAN and SUN Bo(Institute of Soil Science, the Chinese Academy of Sciences, P.o. Box 821, Naviing 210008 China) | 2000 | Pedosphere2000，10，2： | 3 |
| 10 | SIMULATION OF WELD THERMAL CYCLE USING THE MODEL OF CARBONITRIDE PARTICLES PRECIPITATION显示文摘Based on the chasteal nucleation theory, the kinetic precipitation model of carbon - nitride particles in weld HAZ is proposed. Using the model,welding simulation technology and the quantitative metallo- graphic analysis,the precipitation transformation temperatue (PTT) curve is obtained.The data from the simulated welds are in good apreement with the value that the PTT curves predicated. | C. B. Cui S. H. Yang Z. Xiong and J. B. Hong (University Navy Engineering, Wuhan, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 2 |
| 11 | Five New MVL Current Mode Differential Absolute Value Circuits Based on Carbon Nano-tube Field Effect Transistors(CNTFETs)显示文摘Carbon Nano-Tube Field Effect Transistors(CNTFETs) are being widely studied as possible successors to silicon MOSFETs.Using current mode has many advantages such as performing sum operation by means of a simple wired connection.Also,direction of the current can be used to exhibit the sign of digits.It is expected that the advantages of current mode approaches will become even more important with increased speed requirements and decreased supply voltage.In this paper,we present five new circuit designs for differential absolute value in current mode logic which have been simulated by CNTFET model.The considered base current for this model is 2 μA and supply voltage is 0.9 V.In all of our designs we used N-type CNTFET current mirrors which operate as truncated difference circuits.The operation of Differential Absolute Value circuit calculates the difference between two input currents and our circuit designs are operate in 8 logic levels. | Mojtaba Jamalizadeh Fazel Sharifi Mohammad Hossein Moaiyeri Keivan Navi Omid Hashemipour | 2010 | Nano-Micro Letters2010，2，4： | 2 |
| 12 | Renal function in glycogen sto- rage disease type I, natural course, and renopreservative effects of ACE inhibition 显示文摘 | Martens DH Rake JP Navis G | 2009 | Clin J Am Soc Nephrol2009，4，11： | 1 |
| 13 | Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta -analysis of randomized clinical trials 显示文摘 | Kamel H Navi BB Nakagawa K | 2011 | Crit Care Med2011，39，3： | 1 |
| 14 | Design of a novel reversible muhiplier circuit using HNG gate in nanotechnolo- gy 显示文摘 | Haghparast M Jassbi S J Navi K | 2008 | World Applied Sciences2008，3，6： | 1 |
| 15 | Viral replication capacity as a correlate of HLA-B57/B5801-associated nonprogressive HIV-1 infection显示文摘 | Navis M Schellens I van Baarle D | 2007 | J Immunol2007，179，5： | 1 |
| 16 | Recognition of Partially Occluded Objects Using Neural Network Based Indexing显示文摘 | Rajpal Navi Chaudhury Stantanu Banerjee Subhashis | 1999 | Pattern Recognition1999，，32： | 1 |
| 17 | Impaired renal function in patients with ischemic and nonischemic chronic heart failure:Association with neurohormonal activation and survival显示文摘 | Smilde TD Hillege HL Navis G | 2004 | Am Heart J2004，148，1： | 1 |
| 18 | Vitamin D in chronic kidney disease:new potential for intervention显示文摘 | Mirkovic K Van den Born J Navis G | 2011 | Curr Durg Targets2011，12，1： | 1 |
| 19 | Simulation of cement paste microstructure hydration, pore space characterization and permeability 显示文摘 | PIGNAT C NAVI P SCRIVENVER K | 2005 | Material and Structure2005，38，4： | 1 |
| 20 | Surface area congruence of atlas superior articulating facets and occipital condyles显示文摘 | Briggs L Hart J Navis M | 2008 | J Chiropr Med2008，7，1： | 1 |
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