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1MicroRNAs and immunity in periodontal health and disease显示文摘MicroRNAs(miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients. In the present study, we mapped the major miRNAs that were altered in our reproducible periodontitis mouse model relative to control animals. The miRNAs that were upregulated as a result of periodontal disease in both human and mouse studies included miR-15 a, miR-29 b, miR-125 a, miR-146 a,miR-148/148 a and miR-223, whereas miR-92 was downregulated. The association of individual miRNAs with unique aspects of periodontal disease and their stability in gingival crevicular fluid underscores their potential as markers for periodontal disease progression or healthy restitution. Moreover, miRNA therapeutics hold great promise for the future of periodontal therapy because of their ability to modulate the immune response to infection when applied in conjunction with synthetic antagomirs and/or relatively straightforward delivery strategies.Xianghong Luan Xiaofeng Zhou Afsar Naqvi Marybeth Francis Deborah Foyle Salvador Nares Thomas G.H.Diekwisch 2018International Journal of Oral Science2018,10,3:10
2Optimizing the seed-cell filling performance of an inclined plate seed metering device using integrated ANN-PSO approach显示文摘Uniformseed distribution within the row is the prime objective of precision planters for better crop growth and yield.Inclined plate planters are generally used for sowing bold seeds likemaize,groundnut,chickpea,and their operating parameters like the forward speed of operation,the seedmetering plate inclination,and the seed level in the hopper affect the cell fill and subsequently the uniformseed distribution.Therefore,to achieve precise seed distribution,these parameters need to be optimized.In the present study,out of the different optimization techniques,a new intelligent optimization technique based on the integrated ANN-PSO approach has been used to achieve the set goal.A 3–5-1 artificial neural network(ANN)model was developed for predicting the cell fill of inclined plate seedmetering device,and the particle swarmoptimization(PSO)algorithmwas applied to obtain the optimum values of the operating parameters corresponding to 100%cell fill.The most appropriate optimal values of the forward speed of operation,the seed metering plate inclination,and the seed level in the hopper for achieving 100%cell fill were found to be 3 km/h,50-degree,and 75%of total height,respectively.The proposed integrated ANN-PSO approach was capable of predicting the optimal values of operating parameters with amaximumdeviation of 2%compared to the experimental results,thus confirmed the reliability of the proposed optimization technique.C.M.Pareek V.K.Tewari Rajendra Machavaram Brajesh Nare 2021Artificial Intelligence in Agriculture2021,,1:4
3MicroRNA modulation in obesity and periodontitis显示文摘Perri R Nares S Zhang S 2012J Dent Res2012,91,1:1
4Mesenchymal Stem CellsAcquire Characteristics of Cells in the Periodontal Ligament invitro显示文摘Kramer PR Nare S Kramer SF 2004J Dent Res2004,83,1:1
5Mesenchymal stem cells acquire characteristics of cells in the periodontal ligament in vitro显示文摘Kramer PR Nares S Kramer SF 2004J Dent Res2004,83,1:1
6Empowering water quality management in Lamtakhong River basin ,Thailand using WASP mod- el 显示文摘NARES C SUBUNTITH N SUKANDA C 2013Research Journal of Applied Sciences : Engineering and Tech- nology2013,6,23:1
7Micro RNA modulation in obesity and periodontitis显示文摘Perri R Nares S Zhang S 2012J Dent Res2012,91,1:1
8Mesenchymal stem cells acquire characteristics of cells in the periodontal ligamentin vitro 显示文摘Kramer PR Nares S Kramer SF 2004J Dent Res2004,83,1:1
9Diabetes-induced impairment of macrophage cytokine release in a rat model:potential role of serum lipids显示文摘Doxey DL Nares S Park B 1998Life Sci1998,63,13:1
10Hybridizing A Genetic Algorithm with An Artificial Immune System for Global Optimization显示文摘Coello Carlos A Coello Cortes Nareli Cruz 2004Engineering Optimization2004,36,5:1
11Mesenchymal stem cells acquire characteristics of cells in the perio- dontal ligament in vitro显示文摘Kramer PR Nares S Kramer SF 2004J Dent Res2004,83,1:1
12Mesenchymal stem cells acquire characteristics of cells in the periodontal ligament in vitro显示文摘Kramer P R Nares S Kramer S F 2004J Dent Res2004,83,1:1
13Diabetes-induced impairment of maerophage cytokine release in a rat model: potential role of serum lipids显示文摘Doxey DL Nares S Park B 1998Life Sci1998,63,13:1
14A fuzzy logic algorithm derived mechatronic concept prototype for crop damage avoidance during eco-friendly eradication of intra-row weeds显示文摘Crop damage during the intra-row weed eradiation is one of the biggest challenges in intercultural agricultural operations.Several available mechanical systems provide effective weeding but result in excess crop damage.On the other hand,chemical based systems have been raising serious environmental and food concerns.This study presents development of a cost-effectivemechatronic prototype for intra-rowweeding operation.The primary focus was on incurring minimal crop damage.The system integrates time of flight and inductive sensing into fuzzy logic algorithm for electronic control of a four-bar linkage mechanism(FBLM).The crank of FBLM was connected to the vertical rotary weed control shaft with weeding blades.The crop sensing triggers the electronic control to laterally shift the control shaft away from crop,proportional to the forward speed and soil conditions.The developed algorithm incorporates varied conditions of soil,forward speed,and plant spacing to calculate dynamic lateral shift speed(SRPM).The prototype was evaluated to determine the relationships between the operating conditions and electronic control parameters.Moreover,the plant damage was assessed under varied conditions of plant spacing,forward speeds,soil cone index,operational depth and electronic control parameters.The derived SRPM was established as the ultimate governing factor for avoiding crop damage that varied significantlywith electronic response time and soil strength(P<0.05).Plant damage increased significantly under higher forward speeds and lower plant spacing(P<0.05).Preliminary field evaluation of the developed prototype showed a significant potential of this system for effective control on weeds(>65%)and crop damage(<25%).Satya Prakash Kumar V.K.Tewari Abhilash K.Chandel C.R.Mehta Brajesh Nare C.R.Chethan Kaustubh Mundhada Prateek Shrivastava Chanchal Gupta Smrutilipi Hota 2020Artificial Intelligence in Agriculture2020,,1:1
15Study of Subcritical Crack Growth in Andesite Using the Double Torsion test显示文摘NARE Y KANEKO K 2005Internation- al Journal of Rock Mechanics and Mining Sciences2005,42,:1
16Coello Coello, Multiobjective Optimization Using Ideas from the Clonal Selection Principle 显示文摘Nareli Cruz Cortes Carlos A 2003Lecture Notes in Computer Science2003,2723,:1
17Comparison of silica-supported MoO3and V2O5 catalysts in the selective partial oxidation of methane显示文摘Faraldos M Ba(a)nares M A Anderson J A 0,,02:1
18Subcritical Crack Growth in Aniso- tropic Rock 显示文摘NARE Y KANEKO K International Journal of Rock Mechanics and Mining Sciences0,43,3:1
19Mesenchymal stem cells acquire characteristics of cells in the periodontal liga- ment in vitro显示文摘Kramer PR Nares S Kramer SF 2004J Dent Res2004,83,1:1
20Mesenchymal stem cells acquire characteristics of cells in the periodontal ligament in vitro显示文摘Kramer PR Nares S Kramer SF 2004J Dent Res2004,83,1:1
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