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| 1 | Role of liver biopsy in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD), defined as abnormal accumulation(> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis(NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the 'gold standard' for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease. | ILKe Nalbantoglu Elizabeth M Brunt | 2014 | World Journal of Gastroenterology2014，20，27： | 16 |
| 2 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 3 | Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation显示文摘BACKGROUND Primary sclerosing cholangitis(PSC)associated inflammatory bowel disease(IBD)is a unique form of IBD(PSC-IBD)with distinct clinical and histologic features from ulcerative colitis(UC)and Crohn disease(CD).In patients with PSC and IBD,the severity of the two disease processes may depend on each other.AIM To study the histologic and clinical features of PSC patients with and without IBD.METHODS We assessed specimens from patients with UC(n=28),CD(n=10),PSC and UC(PSC-UC;n=26);PSC and CD(PSC-CD;n=6);and PSC and no IBD(PSC-no IBD;n=4)between years 1999-2013.PSC-IBD patients were matched to IBD patients without PSC by age and colitis duration.Clinical data including age,gender,age at IBD and PSC diagnoses,IBD duration,treatment,follow-up,orthotopic liver transplantation(OLT)were noted.RESULTS PSC-UC patients had more isolated right-sided disease(P=0.03),and less active inflammation in left colon,rectum(P=0.03 and P=0.0006),and overall(P=0.0005)compared to UC.They required less steroids(P=0.01)and fewer colectomies(P=0.03)than UC patients.The PSC-CD patients had more ileitis and less rectal involvement compared to PSC-UC and CD.No PSC-CD patients required OLT compared to 38%of PSC-UC(P=0.1).PSC-IBD(PSC-UC and PSCCD)patients with OLT had severe disease in the left colon and rectum(P=0.04).CONCLUSION PSC-UC represents a distinct form of IBD.The different disease phenotype in PSC-IBD patients with OLT may support liver-gut axis interaction,however warrants clinical attention and further research. | John Aranake-Chrisinger Themistocles Dassopoulos Yan Yan ILKe Nalbantoglu | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 4 | End-to-end versus aug- mented repair in the treatment of acute Achilles Tendon ruptures显示文摘 | Aktas S Kocaoglu B Nalbantoglu U | 2007 | J Foot Ankle Surg2007，46，5： | 1 |
| 5 | Open reduction and imernal fixation of Mason type llI radial head fractures with and without an associ- ated elbow dislocation显示文摘 | Nalbantoglu U Koeaoglu B Gereli A | 2007 | J Hand Surg2007，32，10： | 1 |
| 6 | Effectiveness of class C fly ash: an expansive soil stabilizer 显示文摘 | NALBANTOGLU Z | 2004 | Construction and Building Materials2004，18，6： | 1 |
| 7 | Metagenomic analysis of the microbial community in kefir grains显示文摘 | NALBANTOGLU U CAKAR A DOGAN H | 2014 | Food Microbiol2014，，41： | 1 |
| 8 | Musclespecific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle 显示文摘 | Nalbantoglu J Larochelle N Wolf E | 2001 | J Virol2001，75，9： | 1 |
| 9 | System identification with generalized orthonormal basis functions: application to flexible structures 显示文摘 | NALBANTOGLU V JOZSEF B BALAS G GASPAR P | 2003 | Control Engineering Practice2003，11，3： | 1 |
| 10 | Cytosolic flagellin receptor NLRCA protects mice against mucosal and systemic challenges 显示文摘 | Carvalho FA Nalbantoglu I Aitken JD | 2012 | Mucosal Immunol2012，5，3： | 1 |
| 11 | Alzheimer's beta-armamloid precursor protein is expressed on the surface of immediately exvivo brain cell: a flow cytometric study显示文摘 | Jung SS Nalbantoglu J Cashman NK | 1996 | J Neurosci Res1996，46，3： | 1 |
| 12 | Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies显示文摘 | Nalbantoglu J Gilfix BM Bertrand P | 1994 | Ann Neurol1994，36，6： | 1 |
| 13 | Open reduction and internal fixation of Mason type III radial head fractures with and without an associated elbow dislocation 显示文摘 | Nalbantoglu U Kocaoglu B Gereli A | 2007 | J Hand Surg Am2007，32，10： | 1 |
| 14 | Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells 显示文摘 | Nalbantoglu J Pari G Karpati G | 1999 | Hum Gene Ther1999，10，6： | 1 |
| 15 | Comparative study of theclosed reduction percutaneous cannulated screw fixation and open reduction palmar locking plate fixation in the treatment of AO type A2 distal radius fractures显示文摘 | Gereli A Nalbantoglu U Kocaoglu B | 2014 | Arch Orthop Trauma Surg2014，134，1： | 1 |
| 16 | Effects of salicylic acid and salinity on apoplastic antioxidant enzymes in two wheat cultivars differing in salt tolerance显示文摘 | Muflu S Atici O Nalbantoglu B | 2009 | Biol Plant2009，53，2： | 1 |
| 17 | Effects of salicylic acid and cold treatments on protein levels and on the activities of antioxidant enzymes in the apoplast of winter wheat leaves 显示文摘 | Tasgin E Atici O Nalbantoglu B | 2006 | Phytoehemistry2006，67，7： | 1 |
| 18 | System identification with generalized orthonormal basis functions: an application to flexible structures显示文摘 | Nalbantoglu V Bokor J Balas G | 2003 | Control Engineering Practice2003，11，3： | 1 |
| 19 | Suicide gene therapy with an adenovirus expressing the fusion gene CD:UPRT in human glioblastomas:different sensitivities correlate with p53 status显示文摘 | Bourbeau D Lavoie G Nalbantoglu J | 2004 | J Gene Med2004，6，： | 1 |
| 20 | Technique of Kirschner wire reduction and fixation of displaced two-part valgus angulated proximal humerus fractures at the surgical neck显示文摘 | Seyhml M Kocaoglu B Nalbantoglu U et ol | 2012 | J Orthop Trauma2012，26，6： | 1 |
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