|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current role and future perspectives of cardiac rehabilitation in coronary heart disease显示文摘Ischaemic heart disease(IHD)is a major cause of morbidity and mortality worldwide.While there have been major advances in this field,these patients are still a higher risk subgroup.As such,strategies to mitigate risk and tailor secondary prevention measures are of the utmost relevance.Cardiac rehabilitation(CR),encompassing several domains including exercise training,cardiovascular risk factor optimization,nutritional and psychological assessments,as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with IHD.Indeed,CR is associated with several benefits in this population,ranging from functional capacity to improvements in outcomes.Whilst this,there are still several issues concerning the optimal application of CR which are still not fully ascertained,such as lack of referral and completion,as well as questions related to programme design(particularly among patients with multiple comorbidities).In this review,we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD,while also discussing some of the caveats in the current data,as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention. | Eduardo M Vilela Ricardo Ladeiras-Lopes Ana Joao Joana Braga Susana Torres Sofia Viamonte José Ribeiro Madalena Teixeira José P Nunes Ricardo Fontes-Carvalho | 2021 | World Journal of Cardiology2021，13，12： | 5 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Membranes of poly(ether imide) and nanodispersed silica显示文摘 | Peinemann K V Ohlrogge K | 1999 | J Membr Sci1999，157，： | 1 |
| 4 | Advances in the neurohiology of hearing disorder-s: recent developments regarding the basis of tinnitus and hyperaeusis显示文摘 | Knipper M Van D P Nunes 1 | 2013 | Prog Neurobiol2013，111，： | 1 |
| 5 | Measuring the Economic Value of Alternative Clam Fishing Management Practices in the Venice Lagoon:Results from a Conjoint Valuation Application显示文摘 | Nunes P A L D Rossetto L de Blaeij A | 2004 | Journal of Marine Systems2004，，1： | 1 |
| 6 | Magnetic microstructure of YFell Ti aggregates 显示文摘 | Nunes D Colaco R de Hosson JTM Gonclves A P Pereira L C J Carvalho P A | 2009 | Journal of Alloys and Compounds2009，487，12： | 1 |
| 7 | Renal diseases: a 27-year renal biopsy study显示文摘 | Carvalho E do-Sameiro-Faria M Nunes J P | 2006 | J Nephrol2006，19，4： | 1 |
| 8 | Validation of an immunoassay method for the determination of traces of carbaryl in vegetable and fruit extracts by liquid chromatography with photodiode array and mass spectrometric detection显示文摘 | Nunes G S Marco M P Ribeiro M L | 1998 | Journal of Chromatography A1998，823，1： | 1 |
| 9 | Acute ischaemic stroke during ambulatory blood pressure monitoring显示文摘 | NUNES J P FRIA M D S POLONIA J J | 1992 | Lancet1992，339，2： | 1 |
| 10 | Sarcoidosis显示文摘 | Nunes H Bouvry D Soler P | 2007 | Orphanet J of Rare Dis- eases2007，2，： | 1 |
| 11 | Membranes for gas separation based on poly(1-trimethyls-ilyl-1-propyne)-silica nanocomposites显示文摘 | Gomes D Nunes S P Peinemann K V | 2005 | J Membr Sci2005，246，1： | 1 |
| 12 | Transparent conductive ZnO:A1 thin filmdeposited on polymer substrates by RF magnetron sputtering显示文摘 | Fortunato E Nunes P Marques A | | 0，，： | 1 |
| 13 | A study of theeffect of plasma treatment on the interfacial properties of carbon fibre-thermoplastic composites显示文摘 | Montes-Moran M A Hattum van F W J Nunes J P | 2005 | Carbon2005，43，8： | 1 |
| 14 | Development of a new genera- tion of filament wound composite pressure cylinders 显示文摘 | Velosa J C Nunes J P Antunes P J | 2009 | Composites Science and Technology2009，69，9： | 1 |
| 15 | Production of MLM - type structured lipids catalyzed by immobilizd heterologous Rhizopus oryzae lipase 显示文摘 | NUNES P A PIPES - CABRAL P | 2011 | J Am Oil Chem Soc2011，88，4： | 1 |
| 16 | Ultrafiltration membranes from PVDF/PMMA blends 显示文摘 | NUNES S P PEINEMANN K V | 1992 | J Membr Sci1992，73，1： | 1 |
| 17 | Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder 显示文摘 | Nunes P V Forlenza O V Gattaz W F | 2007 | Br J Psychiatry2007，190，： | 1 |
| 18 | Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomv in the rat显示文摘 | Carrier S Zvara P Nunes L | 1995 | J Urol1995，153，5： | 1 |
| 19 | Insulin and met- formin may prevent renal injury in young type 2 diabetic Goto-Kak- izaki rats显示文摘 | Louro T M Matafome P N Nunes E C | 2011 | Eur J Pharmacol2011，653，13： | 1 |
| 20 | A model for sustainable management of shellfish polyculture in coastal bays 显示文摘 | NUNES J P FERREIRA J G GAZEAU F | 2003 | Aquaculture2003，219，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员