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| 1 | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies显示文摘Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages:(i) triggering,(ii) maturation,(iii) targeting, and(iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies(including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. | Qiang Guo Yuxiang Wang Dan Xu Johannes Nossent Nathan J.Pavlos Jiake Xu | 2018 | Bone Research2018，6，2： | 71 |
| 2 | Sobol’ sensitivity analysis of a complex environmental model显示文摘 | Jiri Nossent Pieter Elsen Willy Bauwens | 2011 | Environmental Modelling and Software2011，，12： | 2 |
| 3 | Anti -double -stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradions? 显示文摘 | Rekvig OP Nossent JC | 2003 | Arthritis Rheum2003，48，2： | 1 |
| 4 | Quantitative salivary gland scintigraphy can distinguish patients with primary Sjogren's syndrome during the evaluation of sicca symptoms显示文摘 | Henriksen A M Nossent H C | | 0，，11： | 1 |
| 5 | Polymorphism in the 5'regulatory region of the B-lymphocyte activating factor gene isassociated with the Ro/La autoantibody response and serum BAFFlevels in primary Sjogren ’ s syndrome 显示文摘 | Nossent JC Lester S Zahra D | 2008 | Rheumatology(Oxford)2008，47，9： | 1 |
| 6 | Increased ferritin response in adult Still's disease: speeifieity and relationship to outcome 显示文摘 | Evensen KJ Swaak TJ Nossent JC | 2007 | Scand J Rheumatol2007，36，2： | 1 |
| 7 | Levels of transforming growth factor-beta are low in systemic lupus erythematosus patients with active disease显示文摘 | Becker-Merok A Eilertsen G? Nossent JC | 2010 | J Rheumatol2010，37，10： | 1 |
| 8 | Sobol' sensitivity analysis of a complex environmental model 显示文摘 | Nossent J P Elsen | 2011 | Environmental Modelling and Software2011，26，12： | 1 |
| 9 | Sobol' sensitiv-ity analysis of a complex environmental model显示文摘 | NOSSENT J ELSEN P BAUWENS W | 2011 | En-vironmental Modelling & Software2011，26，12： | 1 |
| 10 | Anti - double - stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms? 显示文摘 | Rekvig OP Nossent JC | 2003 | Arthritis Rheum2003，48，2： | 1 |
| 11 | B - lymphocyte activa- ting factor in systemic lupus erythematosus and rheumatoid arthritis in relation toautoantibody levels, disease measures and time 显示文摘 | Becker - Merok A Nikolaisen C Nossent HC | 2006 | Lupus2006，15，9： | 1 |
| 12 | Acute myelogenous leukaemia following etanereept therapy显示文摘 | Bakland G Nossent H | 2003 | Rheumatology(Oxford)2003，42，9： | 1 |
| 13 | Sobol' Sensitivity Analysis of a Complex Environmental Model显示文摘 | Nossent J Elsen P Bauwens W | 2011 | En- vironmental Modelling & Software2011，26，12： | 1 |
| 14 | Long-term efficacy of azathioprine treatment for proliferative lupus nephritis显示文摘 | Nossent HC Koldingsbes W | 2000 | Rheumatol2000，39，： | 1 |
| 15 | Contribution of renal biopsy data in predicting outcome in lupus nephritis, analysis of 116 patients显示文摘 | Nossent HC Henzan-Logmans SC Vroom TM | 1999 | Arthritis Rheum1999，33，： | 1 |
| 16 | Renal immunofluorescence and the prediction of renal outcome in patients with proliferative lupus nephritis显示文摘 | Nossent H Berden J Swaak T | 2000 | Lupus2000，9，7： | 1 |
| 17 | SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction显示文摘 | Nossent AY Hansen JL Doggen C | 2011 | Am J Hypertens2011，24，9： | 1 |
| 18 | Prior anti-dsDNA antibody status does not predict later disease manifestations in systemic lupus erythematosus显示文摘 | van den Berg L Nossent H Rekvig O | | 0，，03： | 1 |
| 19 | The 14q32 microRNA-487b targets the anti- apoptotic insulin receptor substrate 1 in hypertension- induced remodeling of the aorta 显示文摘 | NOSSENT A Y ESKILDSEN T V ANDERSEN L B | 2013 | Ann Surg2013，258，5： | 1 |
| 20 | B- lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, di- sease measures and time显示文摘 | BECKER-MEROK A NIKOLAISEN C NOSSENT H C | 2006 | Lupus2006，15，9： | 1 |
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