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| 1 | 老年冠心病患者经皮冠状动脉腔内成形术结果评价显示文摘目的评价一组老年冠心病患者行经皮冠状动脉腔内成形术(PTCA)的疗效。方法将65例老年(89支血管)和117例老年前期(149支血管)冠心病患者的PTCA结果作对比研究。结果老年组血管扩张成功率94.4%,临床成功率92.3%,主要并发症发生率为6.1%,再狭窄发生率为32.5%。以上结果与老年前期组比较差异均无显著性。术后症状改善率两组相同,都在90.0%以上。仅老年组再次PTCA频率明显高于老年前期组(x2检验,P值<0.05)。结论对于老年冠心病患者,PTCA是一种有效及安全的冠脉血管重建措施。 | 杨天和 Noll,B | 1996 | 中华老年医学杂志1996，15，1： | 7 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | Endothelial function as an end-point in interventional trial: concepts, methods and current data 显示文摘 | Luscher TF Noll G | 1996 | J Hypertension1996，14，2： | 1 |
| 4 | Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke显示文摘 | Small SL Hlustik P Noll DC | 2002 | Brain2002，125，7： | 1 |
| 5 | Lateralization of motor circuits and handedness during finger movements显示文摘 | Solodkin A Hlustik P Noll DC | 2001 | Eur J Neurol2001，8，5： | 1 |
| 6 | Ouantitatively determined survivmexpression level are prognostic value in human gliomas显示文摘 | Chakravarti A Noll E Black PM | 2002 | Clin Oncol2002，20，4： | 1 |
| 7 | Molecular pathways of aging and hypertension 显示文摘 | Camici GG Sudano I Noll G | 2009 | Curr Opin Nephrol Hypertens2009，18，2： | 1 |
| 8 | Quantitatively determined Sur- vivin expression levels are of prognostic value in human gliomas 显示文摘 | Chakravarti A Noll E Black PM | 2002 | J Clin Oncol2002，20，4： | 1 |
| 9 | Adhesion molecules in normal and pathological corneas显示文摘 | Vorkauf W Vorkauf M Nolle B | 1995 | Graefes Arch Clin Exp Ophthalmol1995，233，4： | 1 |
| 10 | Prognos- tic and pathologic significance of quantitative protein expression profiling in human gliomas显示文摘 | Chakravarti A Delaney M A Noll E | 2001 | Clin Cancer Res2001，7，： | 1 |
| 11 | Schnelle multielement analyse in der stahl- schmelze mit laserinduzierter emissionsspektrometrie 显示文摘 | Noll R | 1997 | Stahl und Eisen1997，117，1： | 1 |
| 12 | Neurocognitive functioning in patients with glioma of the left and right temporal lobes显示文摘 | Noll KR Ziu M Weinberg JS | 2016 | J Neurooncol2016，，： | 1 |
| 13 | Corporate Governance in China: Is Economic Growth Potential Hindered by Guanxi 显示文摘 | BRAENDLE UDO GASSER TANJA & NOLL JUERGEN | 2005 | Business and Society Review2005，110，4： | 1 |
| 14 | Quantitatively determined survivin expression level are of prognotic value in human gliomas 显示文摘 | Chakravarti A Noll E Block PM | 2002 | J Clin Oncol2002，20，4： | 1 |
| 15 | Functional topographic mapping of the cortical ribbon in human vision with conventional MRI scanners显示文摘 | Schneider W Noll DC Cohen JD | 1993 | Nature1993，365，6442： | 1 |
| 16 | Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers 显示文摘 | Heller G Weinzierl M Noll C | 2012 | Clin Cancer Res2012，18，6： | 1 |
| 17 | Broadcasting and team sports显示文摘 | NOLL ROGER G | 2007 | Scottish J Political Economy2007，54，3： | 1 |
| 18 | Temporal dynamics of brain activation during a working memory task显示文摘 | Cohen J.D Perlstein W.M Braver T.S Nystrom L.E Noll D.C Jonides J & Smith E.E | | 0，，： | 1 |
| 19 | Zernike polynomials and atmospheric turbulence 显示文摘 | Noll R J | 1976 | Journal of the Optical Society of America A($1520-8532)1976，66，3： | 1 |
| 20 | Endothelin receptor antagonists in congestive heart failure:a new therapeutic principle for the future显示文摘 | Noll G Ruschitzka FI | 2001 | J Am Coll Cardiol2001，37，6： | 1 |
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