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| 1 | 孕前血压及其到妊娠早期的变化:先兆子痫和妊娠期高血压的早期危险因素显示文摘先兆子痫和妊娠期高血压是常见的妊娠并发症,与母婴发病率显著相关。尽管对怀孕期间的危险因素进行了广泛的研究,但大多数患妊娠期高血压疾病的妇女并不被认为是高风险的,预防措施仍不清楚。研究者评估了妊娠前的血压及其到妊娠早期的变化,将其作为妊娠高血压疾病发展新的危险标志。 | 刘青(译) 刘莉(摘/审校) Nobles CJ Mendola P Mumford SL Silver RM Kim K Andriessen VC Connell M Sjaarda L Perkins NJ Schisterman EF | 2020 | 中华高血压杂志2020，28，12： | 12 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 4 | Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis显示文摘 | Simon IR Noble Mike D Shelley Bernadette Coles Susan M Williams Andrew Wilcock Miriam J Johnson | 2008 | Lancet Oncology2008，，6： | 2 |
| 5 | Transforming growth factor-beta and angiotensin Ⅱ:The missing Link from glomerular hyperfiltration to glomerulosclerosis?显示文摘 | Ketteler M Noble NA Border WA | 1995 | Annu Rev Physiol1995，57，： | 1 |
| 6 | The effectiveness of problem-based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 7 | The effectiveness of prolem based learning compared to traditional teaching in under graduate psychiatry显示文摘 | Mc Parland M Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 8 | The effectiveness of Pro- blem based learning compared to traditional teaching in under- graduate psychiatry显示文摘 | McParland M Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 9 | Characterization of highly stable liposomal and immunoliposornal for mulations of vineristine and vinblastine 显示文摘 | Noble C O Guo Z Hayes M E | 2009 | Cancer Chemoth Pharm2009，64，4： | 1 |
| 10 | The effectiveness of problem based learning compared to traditional teaching in under graduate psychiatry显示文摘 | Mc Parland M Noble LM Livingston G | 2004 | Med Educ2004，38，： | 1 |
| 11 | The effectiveness of problem-based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | Mcpanland M Noble LM Uvingston G | 2004 | Med Educ2004，38，8： | 1 |
| 12 | The effectiveness of problem based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | Mc Parland M Noble LM Livingston G | 2004 | Med Educ2004，38，： | 1 |
| 13 | The effectiveness of problembased learning compared to traditional teaching in undergraduate psychiatry 显示文摘 | MeParland M Noble LM Livingston G | 2004 | Med Edu2004，38，8： | 1 |
| 14 | The effectiveness of problem_based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 15 | The effectiveness of problem-based learning compared to traditional teaching in un- der-graduate psychiatry 显示文摘 | McParland M Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 16 | Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation显示文摘 | Weylandt KH Valverde MA Nobles M | 2001 | J Biol Chem2001，276，17： | 1 |
| 17 | The effectiveness of problem-based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | McParland M Noble LM Livingston G | 2004 | Med Edu2004，38，8： | 1 |
| 18 | The effectiveness of problembased learning compared to traditional teaching inundergraduate psy-chiatry 显示文摘 | McParland M Noble L M Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 19 | Dikehosted ores of the Beast deposit and the importance of Eocene magmatism in gold mineralization of the Carlin trend, Nevada 显示文摘 | Ressel M W Noble D C Henry C D | 2000 | Economic Geology2000，，95： | 1 |
| 20 | Cancer stem cells显示文摘 | Jordan CT Guzman ML Noble M | 2006 | N Engl J Med2006，355，12： | 1 |
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