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| 1 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 2 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 3 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 4 | Expression transforming growth factor-βeta isoforms in human glomerular disease显示文摘 | YAMAMOTO T NOBLE N A COHEN A H | 1996 | Kidney Int1996，49，2： | 2 |
| 5 | Maturation effects on absolute biomarker concentration in a suite of coals and associated vitrinite concentrates 显示文摘 | Dzou L I P Noble R A | 1995 | Org Geochemistry1995，23，7： | 2 |
| 6 | Assessment of intubating conditions in adults after inducaion with propofol and varying doses of remifentanil显示文摘 | Crant S Noble S Woods A | 1998 | Br J Anaesth1998，81，4： | 1 |
| 7 | Images as Functions and Sets显示文摘 | Noble J A | 1992 | Image and Vision Comput1992，10，1： | 1 |
| 8 | A Universal Technique for Fast and Flexible Instruction-set Architecture Simulation 显示文摘 | Brann G Nobl A | 2004 | IEEE Transactions on Computer-Aided Design of Integrated CircuitS and Systems2004，23，12： | 1 |
| 9 | Configurational isomerization in sedimentary bicyclic alkanes 显示文摘 | Noble R A Alexander R Kagi R I | 1987 | Org Geochem1987，11，3： | 1 |
| 10 | Identification of some diterpenoid hydrocarbons in petroleum显示文摘 | Noble R A Alexander R Kagi R I | 1986 | Organic Geochemistry1986，10，： | 1 |
| 11 | Transforming growth factor beta in tissue fibrosis显示文摘 | BORDER W A NOBLE N A | 1994 | N Engl J Med1994，331，19： | 1 |
| 12 | Targeting TGF-beta overexpression:maximizing the antifibrotic actions of angiotensin Ⅱ blockade in anti-Thy1 glomerulonephritis显示文摘 | PETERS H BORDER W A NOBLE N A | 1999 | Nephrol Dial Transplant1999，14，4： | 1 |
| 13 | Fatigue of precipitate strengthened Cu-Ni-Sialloy显示文摘 | Loekyer S A Noble F W | 1999 | Mater Sci Techn1999，15，： | 1 |
| 14 | Finding comers 显示文摘 | J A Noble | 1988 | Image Computing1988，6，2： | 1 |
| 15 | Investigation of the effect of skin contact time on wine flavour显示文摘 | SCHMIDT J O NOBLE A C | 1983 | The American Journal of Enology and Viticulture1983，34，3： | 1 |
| 16 | 显示文摘 | Lockyer S A Noble F W | 1994 | Mater Sci1994，29，： | 1 |
| 17 | Anti-interleukin-8 aut anti- bodies in patients at risk for acute respiratory distress syndrome显示文摘 | Kurdowska A Noble JM Grant LS | 2002 | Crit care Med2002，30，10： | 1 |
| 18 | Transforming growth factor 13 in tissue fibrosis显示文摘 | Border W A Noble N A | 1994 | New Engl J Med1994，331，： | 1 |
| 19 | Evaluation of a general practitioner with special interest service for dermatology:randomised controlled trial显示文摘 | Salisbury C Noble A Horrocks S | 2005 | BM J2005，331，： | 1 |
| 20 | Enteroviruses detected by reverse transcriptase polymerase chain reaction from the coastal waters of Santa Monica Bay, California: Low correlation to bacterial indicator levels显示文摘 | NOBLE R T FUHRMAN J A | 2001 | Hydrobiologia2001，460，： | 1 |
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