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| 1 | Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis显示文摘AIM: To evaluate insulin resistance, cytolysis and nonalcoholic steatohepatitis (NASH) score (NAS) using the Kleiner and Brunt criteria in 54 patients with NASH and mild-to-moderate hypertension, treated with telmisartan vs valsartan for 20 mo. METHODS: All patients met the NCEP-ATP TM(standard dose 20 mg o.d., n = 28). Treatment had to be taken daily at the same hour with no concomitant medication or alcohol consumption allowed. Neither the patient nor the medical staff was aware of treatment group allocation. Paired liver biopsies obtained at inclusion (visit 1) and end of treatment (EOT) were assessed by a single blinded pathologist, not aware of patient or treatment group. Blood pressure, BMI, ALT, AST, HOMA-IR, plasma triglycerides (TG) and total cholesterol (TC) were evaluated at inclusion and every 4 mo until EOT (visit 6). RESULTS: At EOT we noticed a significant decrease in ALT levels vs inclusion in all patients and this decrease did not differ significantly in group T vs group V. HOMA-IR significantly decreased at EOT vs inclusion in all patients but in group T, the mean HOMA-IR decrease per month was higher than in group V. NAS significantly diminished at EOT in all patients with a higher decrease in group T vs group V. CONCLUSION: Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect. | Eugen Florin Georgescu Reanina Ionescu Mihaela Niculescu Laurentiu Mogoanta Liliana Vancica | 2009 | World Journal of Gastroenterology2009，15，8： | 15 |
| 2 | Robust exponential stability of uncertain systems with time-varying delays显示文摘 | Niculescu S I De Souza C E Dugard L | 1998 | IEEE Trans Auto Control1998，43，： | 4 |
| 3 | Correlation of Seebeck coefficient and electric conductivity in polyaniline and polypyrrole显示文摘 | Mateeva N Niculescu H Schlenoff J | 1995 | J Appl Phys1995，83，6： | 2 |
| 4 | Quinohemoprotein alcoholdehydrogenase-based reagentless amperometric biosensor for ethanol monitoring during wine fermentation显示文摘 | Niculescu M Erichsen T Sukharev V | 2002 | Analytica Chimica Acta2002，463，： | 1 |
| 5 | Effects of p21 (Cipl/Wafl) at both the G1/S and the G2/M cell cycle transitions:pRb is a critical determinant in blocking DNA replication and in preventing' endoreduplication 显示文摘 | Niculescu AB Chen X Smeets M | 1998 | Mol Cell Biol1998，18，1： | 1 |
| 6 | DV based positioning in Ad Hoc net- works显示文摘 | NICULESCU D NATH B | 2003 | Journal of Telecommunication Systems2003，22，1234： | 1 |
| 7 | Generalized convexity and the existence of finite time blow-up solutions for an evolutionary problem显示文摘 | Niculescu C P Roventa L | 2012 | Nonl Anal2012，75，1： | 1 |
| 8 | Increased NAD (P)H oxidase and reactive oxygen species in coronary arteries after balloon injury显示文摘 | Shi Y Niculescu R Wang D | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 9 | Further remarks on additional dynamics in various model transformations of linear delay sys- tems显示文摘 | Gu K Niculescu S I | 2001 | IEEE Transactions on Automatic Control2001，46，3： | 1 |
| 10 | Mechanisms of signal transduc- tion activated by sub lytic assembly of terminal comple- ment complexes onnucleated cells 显示文摘 | Niculescu F Rus H | 2001 | Immunol Res2001，24，2： | 1 |
| 11 | Ad-Hoc PositioningSystem(APS)显示文摘 | D Niculescu’B Nath | 2001 | IEEE Global Telecommunications2001，5，06： | 1 |
| 12 | Ad-Hoc positioning system 显示文摘 | Niculescu D Nath B | 2001 | In IEEE GlobeCom2001，11，6： | 1 |
| 13 | On Delay - Dependent Stability for Linear Neutral Systems显示文摘 | IVANESCU D NICULESCU S I DUGARD L | 2003 | Automatica2003，39，： | 1 |
| 14 | DV based positioning in ad hoc networks显示文摘 | Niculescu D Nath B | 2003 | Journal of Telecommunication Systems2003，22，4： | 1 |
| 15 | Activation of the human termipal complement pathway in atherosclerosis显示文摘 | Niculescu F Horca G | 1987 | Clin Immunol Immunopathol1987，41，： | 1 |
| 16 | Robust stabilization for uncertain time-delay systems containing saturating actuators 显示文摘 | NICULESCU S I DION J M DUGRAD L | 1996 | IEEE Trans on Automatic Control1996，41，： | 1 |
| 17 | DV Based Positioning in Ad hoc Networks显示文摘 | Niculescu D Nath B | 2003 | Journal of Telecommunication Systems2003，21，： | 1 |
| 18 | Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall显示文摘 | RUSH G VLAICU R NICULESCU F | 1996 | Atherosclerosis1996，127，： | 1 |
| 19 | Oligodendrocyte cell death in pathogenesis of multiple sclerosis:Protection of oligodendrocytes from apoptosis by complement显示文摘 | Cudrici C Niculescu T Niculescu F | 2006 | J Rehabil Res Dev2006，43，： | 1 |
| 20 | On the passivity of linear delay systems显示文摘 | Niculescu S-I Lozano R | 2001 | IEEE Transactions on Automatic Control2001，46，3： | 1 |
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