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| 1 | Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection显示文摘AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with dyspepsia.METHODS: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori colonization.RESULTS: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of patients.CONCLUSION: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach cancer. | Krystyna Stec-Michalska Slawomir Antoszczyk Grazyna Klupinska Barbara Nawrot | 2005 | World Journal of Gastroenterology2005，11，1： | 17 |
| 2 | Gastric ghrelin in relation to gender,stomach topography and Helicobacter pylori in dyspeptic patients显示文摘AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori(H pylori)infection,bacterial cytotoxicity,topography and gender. METHODS:The study comprised 40 premenopausal women(19 H pylori positive)and 48 men(17 H pylori positive)with functional dyspepsia.All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis.Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay.The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction. RESULTS:In general,infection with H pylori causedan increase in gastric ghrelin level regardless of gender and stomach topography.Significantly more hormone was present in both,noninfected and H pylori positive female samples,as compared to males.The distribution of bacterial strains showed cagA(+)vacA s1m1 and cagA(-)vacA s2m2 genotypes as the most common infections in the studied population.A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative)strain-containing specimens from the antrum and corpus of both gender groups(without statistical significance). CONCLUSION:An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients,especially in those infected with cagA(-) strains,can exert a gastroprotective effect. | Krystyna Stec-Michalska Sebastian Malicki Blazej Michalski Lukasz Peczek Maria Wisniewska-Jarosinska Barbara Nawrot | 2009 | World Journal of Gastroenterology2009，15，43： | 10 |
| 3 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 4 | Plant species differences in particulate matter accumulation on leaf surfaces显示文摘 | Szbo A Popek R Nawrot B | 2012 | Science of the Total Environment2012，，6： | 1 |
| 5 | DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel显示文摘 | Cieslak M Niewiarowska J Nawrot M | | 0，，： | 1 |
| 6 | Allotransplation of cultured parathyroid progenitor cells without immunosuppression:clinical results显示文摘 | Nawrot I Wozniewicz B Tolloczko T et al | 2007 | Transplatation2007，83，： | 1 |
| 7 | C-reactive protein new predictor of adverse outcome in pulmonary arterial hypertension显示文摘 | Quarck R Nawrot T Meyns B | 2009 | J Am Coll Cardiol2009，53，14： | 1 |
| 8 | The phase behavior of the quasiternary system N-methylmorpholine- N-oxide, water and cellulose 显示文摘 | CHANZY H NAWROT S PEGUY A | 1982 | Journal of Polymer Science1982，20，10： | 1 |
| 9 | Phase behavior of the quasitemary system N-methylmopholine-N-oxide, water and cellulose 显示文摘 | Chanzy H Nawrot S Peguy A | 1982 | J Polym Sci1982，10，20： | 1 |
| 10 | An epidemiological appraisal of the association between heart rate variability and particulate air pollution:a meta-analysis显示文摘 | Pieters N Plusquin M Cox B Kicinski M Vangronsveld J Nawrot TS | 2012 | Heart2012，98，： | 1 |
| 11 | Stronger associations between daily mortality and fine particulate air pollution in summer than in winter: evidence from a heavily polluted region in Westem Europe 显示文摘 | Nawrot TS Toffs R Fierens F | 2007 | J Epidemiol Community Health2007，61，2： | 1 |
| 12 | C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension 显示文摘 | Quarck R Nawrot T Meyns B | 2009 | J Am Coll Cardiol2009，53，： | 1 |
| 13 | Barley mutants with increased tolerance to aluminium toxicity显示文摘 | M. Nawrot I. Szarejko M. Maluszynski | 2001 | Euphytica2001，，3： | 1 |
| 14 | C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension 显示文摘 | Quarck R Nawrot T Meyns B | 2009 | J Am Coll Cardiol2009，53，14： | 1 |
| 15 | FHIT--tumor suppressor protein involved in induction of apoptosis and cell cycle regulation显示文摘 | Pecherzewska R Nawrot B | 2009 | Postepy Biochem2009，55，1： | 1 |
| 16 | Antifeeding activity of rotenone and some derivatives towards selected insect storage pest显示文摘 | Nawrot J Harmatha J Kostova I | 1989 | Biochemistry Systematic Ecology1989，，17： | 1 |
| 17 | Effectiveness of antifeedants of plant origin in protection of packaging materials against storage insects显示文摘 | Bloszyk E Nawrot J Harmatha J | 1990 | Journal of Applied Entomology1990，110，1： | 1 |
| 18 | Micro RNAs as potential signatures of environmental exposure or effect:a systematic review显示文摘 | Vrijens K Bollati V Nawrot TS | 2015 | Environ Health Perspect2015，，： | 1 |
| 19 | Antifeeding activity of rotenone and some dervatives towards selected insect storage pests显示文摘 | Harmatha J Kostova I | 1989 | Biochem Systematics and Eoologr1989，17，1： | 1 |
| 20 | The phase behavior of the quasitemary system N-methylmorpholine-N-oxide,water and cellulose显示文摘 | Chanzy H Nawrot S Peguy A | 1982 | Polym Sci1982，20，： | 1 |
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