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| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori显示文摘 | Steffen Backert Michael Naumann | 2010 | Trends in Microbiology2010，，11： | 3 |
| 3 | Curcumin blocks NF-κB and the motogenic response in Helicobacter pylori -infected epithelial cells显示文摘 | Anna Foryst-Ludwig Manfred Neumann Wulf Schneider-Brachert Michael Naumann | 2004 | Biochemical and Biophysical Research Communications2004，，： | 2 |
| 4 | 牙髓治疗后的桩核修复(综述)显示文摘目的牙髓治疗后的牙齿的预后不仅取决于牙髓治疗的成功,也取决于修复类型。这其中包括是否使用桩修复体。材料与方法通过文献综述以建立用桩核对牙髓治疗后的牙齿进行修复的指导原则。结果桩仅仅在牙体组织剩余很少的病例中用作核的固位体,如只有1个或没有洞壁剩余的病例;必须要有2mm的肩领,必要时用外科方法获得。因为必须保持根尖区4~6mm的根充封闭,桩的长度受到限制。短桩宜用粘结性固定。瓷桩折断的风险比纤维桩要大,而后者折断后可以再处理。复合树脂被证实是一种良好的核修复材料。如果牙髓治疗后的牙齿被用作活动义齿的基牙,应该插入桩。结论由于缺乏随机临床研究,这些原则主要是基于证据水平为Ⅱa或Ⅱb的体外实验而得。牙齿组织结构的剩余量是影响桩核适应证的一个重要因素,但这在临床实验和体外实验中尚未得到充分认可。因此,需要进行进一步的前瞻性临床研究。 | Ingrid Peroz Felix Blankenstein Klaus-Peter Lange Michael Naumann 周崇阳(译) 张成飞(校) | 2007 | 中国口腔医学继续教育杂志2007，10，1： | 2 |
| 5 | 经颅超声鉴别帕金森病和非典型帕金森综合征 | Behnke S. Berg D. Naumann M. Becker G. 赵睿 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，7： | 2 |
| 6 | Botulinum toxin for palmar hyperhidrosis显示文摘 | Naumann M Flachenecker P Brocker EB | 1997 | Lancet1997，349，： | 2 |
| 7 | Organizational Citizenship Behavior in Work Groups: A Group Norm Approach显示文摘 | Ehrhart M G Naumann S E | 2004 | Journal of Applied Psychology2004，89，6： | 1 |
| 8 | Wnt signalling inhibits neural differe-ntiation of embryonic stem cells by controlling bone morphogenetic protein expression 显示文摘 | Haegele L Ingold B Naumann H | 2003 | Mol Cell Neurosci2003，24，3： | 1 |
| 9 | Reinforcement effect of adhesively luted fiber reinforced composite versus titanium posts显示文摘 | Naumann M Preuss A Frankenberger R | 2007 | Dent Mater2007，23，2： | 1 |
| 10 | Tyndallometry with the laser flare cell meter in intraocular in flammation 显示文摘 | Kuchle M Nguyen N X Naumann G O | 1994 | Ophthalmologe1994，91，2： | 1 |
| 11 | Organizational citizenship behavior in work groups: A group norm approach 显示文摘 | Ehrhart M G and Naumann S E | 2004 | Journal of Applied Psychology2004，89，6： | 1 |
| 12 | Reinforcement effect of adhesively luted fiber reinforced composite versus titanium posts显示文摘 | Naumann M Preuss A Frankenberger R | 2007 | Dent Mater2007，23，2： | 1 |
| 13 | Influence of core material on fracture resistance and marginal adaptation of restored root filled teelb 显示文摘 | Reill M I Rosentritt M Naumann M | 2008 | In t Endod J2008，41，5： | 1 |
| 14 | Microbial decontamination and wei ght ofcarcass beef as affected by automated washing pressure and length of time of spray显示文摘 | Crouse J D Anderson M E Naumann H D | 1988 | JFood Prot1988，51，： | 1 |
| 15 | Cleanli- ness of dentinal tubules following gutta-percha removal with and without solvents: A seanning eleetrnn mieroseopic study 显示文摘 | Horvalh SD Altenburger M J Naumann M | 2009 | lnt EndndJ2009，42，11： | 1 |
| 16 | Data Fusion: Resolving Data Conflicts for Integration显示文摘 | Dong X L Naumann F | 2009 | Proceedings of the VLDB Endowment2009，2，2： | 1 |
| 17 | Prospective evaluation of fecal neutrophils-derived proteins in identifying intestinal inflamma- tion : combination of parameters does not improve diagnostic accuracy of calprotectin 显示文摘 | Schroder O Naumann M Shastri Y ct al | 2007 | Aliment Pharmacol Ther2007，26，7： | 1 |
| 18 | 10-year survival evaluation for glass-fiber-supported postendodontic restoration:a prospective observational clinical study显示文摘 | Naumann M Koelpin M Beuer F | 2012 | J Endod2012，38，4： | 1 |
| 19 | A buyer's bases of power显示文摘 | Naumann E Reck R | | 0，，04： | 1 |
| 20 | Beta-glucan in- corporated into a fruit drink effectively lowers serum LDL- cholesterol concentrations显示文摘 | Naumann E van Rees AB Onning G | 2006 | Am J Clin Nutr2006，83，3： | 1 |
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