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| 1 | Current and future pharmacological therapies for managing cirrhosis and its complications显示文摘Due to the restrictions of liver transplantation,complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis.This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications,together with discussion of current controversies and potential future directions.PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety,efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis.Non-selective betablockers effectively reduce variceal re-bleeding risk in cirrhotic patients with moderate/large varices,but appear ineffective for primary prevention of variceal development and may compromise renal function and haemodynamic stability in advanced decompensation.Recent observational studies suggest protective,haemodynamically-independent effects of beta-blockers relating to reduced bacterial translocation.The gut-selective antibiotic rifaximin is effective for secondary prophylaxis of hepatic encephalopathy;recent small trials also indicate its potential superiority to norfloxacin for secondary prevention of spontaneous bacterial peritonitis.Diuretics remain the mainstay of uncomplicated ascites treatment,and early trials suggest alpha-adrenergic receptor agonists may improve diuretic response in refractory ascites.Vaptans have not demonstrated clinical effectiveness in treating refractory ascites and may cause detrimental complications.Despite initial hepatotoxicity concerns,safety of statin administration has been demonstrated in compensated cirrhosis.Furthermore,statins are suggested to have protective effects upon fibrosis progression,decompensation and mortality.Evidence as to whether proton pump inhibitors cause gut-liver-brain axis dysfunction is conflicting.Emerging evidence indicates that anticoagulation therapy reduces incidence and increases recanalisation rates of non-malignant portal vein thrombosis,and may impede hepatic fibrogenesis and decompensation.Pharmacotherapy for cirrhosis should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management,nutritional optimisation and patient education. | David Kockerling Rooshi Nathwani Roberta Forlano Pinelopi Manousou Benjamin H Mullish Ameet Dhar | 2019 | World Journal of Gastroenterology2019，25，8： | 16 |
| 2 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 3 | Sequential antimicrobial therapy-the role of quinolones显示文摘 | Tillotson G Davey P | 1997 | J Antimicrob Chemother1997，39，： | 1 |
| 4 | Drug hepatotoxicity显示文摘 | Nathwani RA Kaplowitz N | 2006 | Clin Liver Dis2006，10，： | 1 |
| 5 | Autocrine role of gonadotropin-releasing hormone and its receptor in ovarian cancer cell growth 显示文摘 | Kang SK Cheng KW Nathwani PS | 2000 | Endocrine2000，13，： | 1 |
| 6 | Primary nodal marginal zone lymphoma of splenic and MALT type显示文摘 | NATHWANI B N DRACHENBERG M R HERNANDEZ A M | 2000 | Am Surg Pathol2000，24，2： | 1 |
| 7 | Drug hepatotoxicity 显示文摘 | Nathwani RA Kaplowitz N | 2006 | Clin Liver Dis2006，10，2： | 1 |
| 8 | Sequential antibiotic therapy 显示文摘 | Barlow GD Nathwani D | 2000 | Curr Opin Infect2000，13，6： | 1 |
| 9 | Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Anti- microbial AuditTool (GAAT)显示文摘 | Seaton RA Nathwani I) Burton P | 2007 | Int J Antimicrob Agents2007，29，6： | 1 |
| 10 | Drug hepatotoxicity 显示文摘 | Nathwani RA Kaplowitz N | 2006 | Clin Liver Dis2006，10，2： | 1 |
| 11 | Monoclonal small (well-differentiated) lymphocytic proliferations of the gastrointestinal tract resembling lymphoid hyperplasia: a neoplasm of uncertain malignant potential 显示文摘 | Burke JS Sheibani K Nathwani BN | 1987 | Hum Pathol1987，18，12： | 1 |
| 12 | Cryptoccal meningitis显示文摘 | Jones GA Nathwani D | 1995 | British J Hospital Med1995，54，： | 1 |
| 13 | Sustained high-level expression of human factor IX (hFIX) after livertargeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques显示文摘 | Nathwani AC Davidoff AM Hanawa H | 2002 | Blood2002，100，5： | 1 |
| 14 | In vitro uuspal de- flection and mieroleakage of maxillary premolars restored with novel low-shrink dental composites显示文摘 | Palin WM Fleming GJ Nathwani H | 2005 | Dent Mater2005，21，4： | 1 |
| 15 | Antibiotic cycling or rotation:a systematic review of the evidence of efficacy显示文摘 | Brown EM Nathwani D | 2005 | J Antimicrob Chemother2005，55，： | 1 |
| 16 | Linezolid compared with teicoplanin for the tyeatment of suspected or proven Grampositive infections 显示文摘 | Wilcox M Nathwani D Dryden M | 2004 | The Journal of Antimicrolbial Chemotheropy2004，53，2： | 1 |
| 17 | Hospital resource utilization with doripenem versus imipenem in the treatment of ventilator- associated pneumonia 显示文摘 | MERCHANT S GAST C NATHWANI D et O1 | 2008 | Clin Ther2008，30，4： | 1 |
| 18 | An evaluation of the diagnostic accuracy of Pathfinder显示文摘 | Heckerman D E Nathwani B N | 1992 | Computers and Biomedical Research1992，25，1： | 1 |
| 19 | Sequentia antibiotic therapy 显示文摘 | Barlow GD Nathwani D | 2003 | Curr Opin Infect Dis2003，18，4： | 1 |
| 20 | Mul-ticentric angiofollicufar lymph node hyperplasia: a clinico- pathologic study of 16 cases显示文摘 | Weisen burger DD Nathwani BN Winberg CD | 1985 | Hum Pathol1985，9，7： | 1 |
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