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| 1 | A numerical study of the South China Sea deep circulation and its relation to the Luzon Strait transport显示文摘A fine-resolution MOM code is used to study the South China Sea basin-scale circulation and its relation to the mass transport through the Luzon Strait. The modal domain includes the South China Sea, part of the East China Sea, and part of the Philippine Sea so that the currents in the vicinity of the Luzon Strait are free to evolve. In addition, all channels between the South China ,Sea and the Indonesian seas are closed so that the focus is on the Luzon Strait transport. The model is driven by specified Philippine Sea currents and by surface heat and salt flux conditions. For simplicity, no windstress is applied at the surface.The simulated Luzon Strait transport and the South China Sea circulation feature a sandwich vertical structure from the surface to the bottom. The Philippine Sea water is simulated to enter the South China Sea at the surface and in the deep ocean and is carried to the southern basin by western boundary currents. At the intermediate depth, the net Luzon Strait transport is out of the South China Sea and is fed by a western boundary current flowing to the north at the base of the thermocline. Corresponding to the western boundary currents, the basin circulation of the South China Sea is cyclonic gyres at the surface and in the abyss but an anti-cyclonic gyre at the intermediate depth. The vorticity balance of the gyre circulation is between the vortex stretching and the meridional change of the planetary vorticity.Based on these facts, it is hypothesized that the Luzon Strait transports are determined by the diapycnal mixing inside the entire South China Sea. The South China Sea plays the role of a 'mixing mill' that mixes the surface and deep waters to return them to the Luzon Strait at the intermediate depth. The gyre structures are consistent with the Stommel and Arons theory (1960), which suggests that the mixlng-induced circulation inside the South China Sea should be cyclonic gyres at the surface and at the bottom but an anti-cyclonic gyre at the intermediate depth. The simulated gyre circulation at the intermediate depth has been confirmed by the dynamic height calculation based on the Levitns hydrography data.The sandwich transports in the Luzon Strait are consistent with recent hydrographic, al observations.Model results suggest that the Kuroshio tends to form a loop current in the northeastern South China Sea. The simulated Kuroshio Loop Current is generated by the pressure head at the Pacific side of the Luzon Strait and is enhanced by theβ- plane effects. The β- plane appears to be of paramount importance to the South China Sea circulation and to the Luzon Strait translports. Without theβ-plane, the Luzon Strait transports would be greatly reduced and the South China Sea circulation would be complete-ly different. | Yuan Dongliang1. Goddard Earth Science and Technology Center, University of Maryland, Baltimore County Code 971, Laboratory for Hydrospheric Processes, NASA/Goddard Space Flight Center, Greenbelt, MD 20771, USA | 2002 | Acta Oceanologica Sinica2002，21，2： | 37 |
| 2 | Delphi methodology in healthcare research:How to decide its appropriateness显示文摘The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research. | Prashant Nasa Ravi Jain Deven Juneja | 2021 | World Journal of Methodology2021，11，4： | 21 |
| 3 | Euglycemic diabetic ketoacidosis:A missed diagnosis显示文摘Euglycemic diabetic ketoacidosis(DKA)is an acute life-threatening metabolic emergency characterized by ketoacidosis and relatively lower blood glucose(less than 11 mmol/L).The absence of hyperglycemia is a conundrum for physicians in the emergency department and intensive care units;it may delay diagnosis and treatment causing worse outcomes.Euglycemic DKA is an uncommon diagnosis but can occur in patients with type 1 or type 2 diabetes mellitus.With the addition of sodium/glucose cotransporter-2 inhibitors in diabetes mellitus management,euglycemic DKA incidence has increased.The other causes of euglycemic DKA include pregnancy,fasting,bariatric surgery,gastroparesis,insulin pump failure,cocaine intoxication,chronic liver disease and glycogen storage disease.The pathophysiology of euglycemic DKA involves a relative or absolute carbohydrate deficit,milder degree of insulin deficiency or resistance and increased glucagon/insulin ratio.Euglycemic DKA is a diagnosis of exclusion and should be considered in the differential diagnosis of a sick patient with a history of diabetes mellitus despite lower blood glucose or absent urine ketones.The diagnostic workup includes arterial blood gas for metabolic acidosis,serum ketones and exclusion of other causes of high anion gap metabolic acidosis.Euglycemic DKA treatment is on the same principles as for DKA with correction of dehydration,electrolytes deficit and insulin replacement.The dextrosecontaining fluids should accompany intravenous insulin to correct metabolic acidosis,ketonemia and to avoid hypoglycemia. | Prashant Nasa Sandeep Chaudhary Pavan Kumar Shrivastava Aanchal Singh | 2021 | World Journal of Diabetes2021，12，5： | 11 |
| 4 | Severe sepsis and septic shock in the elderly:An overview显示文摘The incidence of severe sepsis and septic shock is increasing in the older population leading to increased admissions to the intensive care units(ICUs). The elderly are predisposed to sepsis due to co-existing comorbidities, repeated and prolonged hospitalizations, reduced immunity, functional limitations and above all due to the effects of aging itself. A lower threshold and a higher index of suspicion is required to diagnose sepsis in this patient population because the initial clinical picture may be ambiguous, and aging increases the risk of a sudden deterioration in sepsis to severe sepsis and septic shock. Management is largely based on standard international guidelines with a few modifications. Age itself is an independent risk factor for death in patients with severe sepsis, however, many patients respond well to timely and appropriate interventions. The treatment should not be limited or deferred in elderly patients with severe sepsis only on the grounds of physician prejudice, but patient and family preferences should also be taken into account as the outcomes are not dismal. Future investigations in the management of sepsis should not only target good functional recovery but also ensure social independence and quality of life after ICU discharge. | Prashant Nasa Deven Juneja Omender Singh | 2012 | World Journal of Critical Care Medicine2012，1，1： | 9 |
| 5 | COVID-19 and the liver: What do we know so far?显示文摘The coronavirus disease 2019(COVID-19)pandemic has caused unprecedented pressure on public health and healthcare.The pandemic surge and resultant lockdown have affected the standard-of-care of many medical conditions and diseases.The initial uncertainty and fear of cross transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have changed the routine management of patients with pre-existing liver diseases,hepatocellular carcinoma,and patients either listed for or received a liver transplant.COVID-19 is best described as a multisystem disease caused by SARS-CoV-2,and it can cause acute liver injury or decompensation of the pre-existing liver disease.There has been considerable research on the pathophysiology,infection transmission,and treatment of COVID-19 in the last few months.The pathogenesis of liver involvement in COVID-19 includes viral cytotoxicity,the secondary effect of immune dysregulation,hypoxia resulting from respiratory failure,ischemic damage caused by vascular endotheliitis,congestion because of right heart failure,or drug-induced liver injury.Patients with chronic liver diseases,cirrhosis,and hepatocellular carcinoma are at high risk for severe COVID-19 and mortality.The phase Ⅲ trials of recently approved vaccines for SARS-CoV-2 did not include enough patients with pre-existing liver diseases and excluded immunocompromised patients or those on immunomodulators.This article reviews the currently published research on the effect of COVID-19 on the liver and the management of patients with pre-existing liver disease,including SARS-CoV-2 vaccines. | Prashant Nasa George Alexander | 2021 | World Journal of Hepatology2021，13，5： | 4 |
| 6 | Unrelated donor stem cell transplantation in adult patients with thalassemia显示文摘 | La Nasa G Caocci G Argiolu F | | 0，，11： | 1 |
| 7 | Risk factors assessment of the difficult intubation using intubation difficulty scale (IDS)显示文摘 | K Nasa V S Kamath S | 2014 | J Clin Diagn Res2014，8，7： | 1 |
| 8 | 永远的辉煌——“阿波罗”登月回顾显示文摘从1969年7月到1972年12月,“阿波罗”号系列宇宙飞船先后6次登上月球,震惊了全世界。时至今日,“阿波罗”登月仍然是人类太空探险历史上历时最长,规模最大、投资最多、影响最广的一项活动,它不仅使人类对月球的认识产生了极大的飞跃,而且在世界航天史上树立了一座丰碑。 | 水天 NASA(图) | 2008 | 中国国家天文2008，，12： | 1 |
| 9 | Role of energy metabolism in the preconditioned hearts possible contribution of mitochondrial 显示文摘 | Takeo S Nasa Y | 1999 | Cardiovascular Research1999，43，1： | 1 |
| 10 | Using Genetic Algorithms to Improve the Search of the Weight Space in Cascade-Correlation Neural Network显示文摘UsingGeneticAlgorithmstoImprovetheSearchoftheWeightSpaceinCascade-CorrelationNeuralNetwork￥E.A.Mayer,K.J.Cios,L.Berke&A.Vary(... | E.A.Mayer, K. J. Cios, L. Berke & A. Vary(University of Toledo, Toledo, OH 43606, U. S. A.)(NASA Lewis Research Center, Cleveland, OH) | 1995 | Journal of Systems Engineering and Electronics1995，6，2： | 1 |
| 11 | Role of energy metabolism in the preconditioned hearts possible contribution of mitochondrial显示文摘 | Takeo S Nasa Y | 1999 | Cardiovasc Res1999，43，1： | 1 |
| 12 | Long-term treatment with neutral endopeptidase inhibitor improves cardiac function and reduces natriuretic peptides in rats with chronic heart failure显示文摘 | Maki T Nasa Y Yamaguchi F | 2001 | Cardiovasc Res2001，51，3： | 1 |
| 13 | Monthly number of cataloged objects in earth orbit by object type显示文摘 | The NASA Orbital Debris Program Office | 2011 | Orbital Debris Quarterly News2011，15，3： | 1 |
| 14 | Preconditioning preserves mitochondrial function and glycolytic flux during an early period of reperfusion in perfused rat hearts 显示文摘 | Nasa Y Sato M | 1997 | Cardiovasc Res1997，33，3： | 1 |
| 15 | The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia显示文摘 | La Nasa G Littera R Locatelli F | 2007 | Br J Haematol2007，139，2： | 1 |
| 16 | Non-linear Behavior of Fiber显示文摘 | NASA CR2313 | 1974 | Composite Lami- nates1974，，： | 1 |
| 17 | Assessing the suitability of current briefing practices in construction within a concurrent engineermg framework显示文摘 | John M Kamara Chimay J Anumba Nasa F O Evbuomwan | 2001 | International Journal of Project Managemenet2001，19，6： | 1 |
| 18 | The a1D-adrenergie receptor directly regulates arterial blood pressure via vasoconstriction显示文摘 | Tauoue A Nasa Y Koshimizu T Shinoura H Ooshikawa S Kawai T | 2002 | J Clin Invest2002，109，： | 1 |
| 19 | Modulation of cAMP-media- ted vasorelaxation by endothelialnitrie oxide and basal cGMP in vascular smooth muscle 显示文摘 | Noyoshima H Nasa Y Hashizume Y | 1998 | J Cardiovasc Pharmacol1998，32，2： | 1 |
| 20 | An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: incidence, risk factors and its impact on outcome显示文摘 | Nasa P Juneja D Singh O | 2012 | Eur JInt Med2012，23，2： | 1 |
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