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| 1 | Bmi-1:At the crossroads of physiological and pathological biology显示文摘Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.Despite three decades of research that have elucidated the transcriptional regulation,post-translational modifications and functions of Bmi-1 in regulating the DNA damage response,cellular bioenergetics,and pathologies,the entire potential of a protein with such varied functions remains to be realized.This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer.Additionally,since cancer stem cells are emerging as a new paradigm for therapy resistance,the role of Bmi-1 in this perspective is also highlighted.The wide spectrum of malignancies that implicate Bmi-1 as a signature for stemness and oncogenesis also make it a suitable candidate for therapy.Nonetheless,new approaches are vitally needed to further characterize physiological roles of Bmi-1 with the long-term goal of using Bmi-1 as a prognostic marker and a therapeutic target. | Resham Bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi | 2015 | Genes & Diseases2015，2，3： | 15 |
| 2 | Prediction of the radiation sensitivity of human squamous cell carcinoma ceils using DNA filter elution 显示文摘 | Schwartz JL Mustafi R Beckett MA | 1990 | Radiat Res1990，123，1： | 1 |
| 3 | Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leu- kemia (CML) cells results in the downregulation of Hsp70显示文摘 | Mustafi S B Chakraborty P K Raha S | 2010 | PLoS ONE2010，5，1： | 1 |
| 4 | miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and pro tooncogenes 显示文摘 | Pekow J R Dougherty U Mustafi R | 2012 | Inflamm Bowel Dis2012，18，1： | 1 |
| 5 | Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK,and Akt显示文摘 | Mustafi S Chakraborty PK Dey RS | 2009 | Cell Stress Chaperones2009，14，： | 1 |
| 6 | Investigation of impact loading rate effects on the ligamentous cervical spinal load-parti- tioning using finite element model of functional spinal unit C2 - C3显示文摘 | Mustafy T El-Rich M Mesfar W | 2014 | J Biomech2014，47，12： | 1 |
| 7 | Human cardiac tissue in a microperfusion chamber simulating extracorporeal circulation- ischemia and apoptosis studies 显示文摘 | Usta E Renovanz M Mustafi M | 2010 | J Cardiothorac Surg2010，5，： | 1 |
| 8 | American ginseng suppresses western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR 显示文摘 | Dougherty U Mustafi R Wang Y | 2011 | BMC Complement Altern Med2011，11，： | 1 |
| 9 | Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators显示文摘 | Cerda SR Mustafi R Little H | 2006 | Oncogene2006，25，22： | 1 |
| 10 | Characterization of exhaust particulates from a dual fuel engine by TGA, XPS, and Raman techniques显示文摘 | Mustafi N N Raine R R James B | 2010 | Aerosol Science and Technology2010，44，11： | 1 |
| 11 | Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration显示文摘 | Yu Chen Grazyna Palczewska Debarshi Mustafi | 2013 | J Clin Invest2013，123，12： | 1 |
| 12 | Some analysis properties of bivariate extreme distribution 显示文摘 | Gumbel E Mustafi C K | 1967 | J Am Stat Assoc1967，62，： | 1 |
| 13 | American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR 显示文摘 | Dougherty U Mustafi R Wang Y | 2011 | BMC Complement Altern Med2011，11，： | 1 |
| 14 | Sorafenib inhibits MAPK- mediated proliferation in a Barrett's esoph- ageal adenocarcinoma cell line显示文摘 | Keswani RN Chumsangsri A Mustafi R | 2008 | Dis Esophagus2008，21，6： | 1 |
| 15 | Surgery on unfavourable persistent N2/N3 non-small-cell lung cancer after trimodal therapy: do the re- suits justify the risk?显示文摘 | Steger V Walker T Mustafi M | 2012 | Interact Cardiovase Thorac Surg2012，15，6： | 1 |
| 16 | EGFR antagonist Iressa inhibits ERK activation, colonic crypt cell proliferation and ACF growth in mouse azoxymethane model of colon cancer显示文摘 | LITTLE N MUSTAFI R CERDA S | 2005 | Gastroenterology2005，128，： | 1 |
| 17 | The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer显示文摘 | Dougherty U Mustafi R Sadiq F | 2014 | Clin Cancer Res2014，20，22： | 1 |
| 18 | The vanadyl(VO^2+) chelate bis (acetylacetonato) oxovanadium(Ⅳ) potentiates tyrosine phosphorylation of the insulin receptor显示文摘 | Qu H Yan L Mustafi D | 2005 | J Biol Inorg Chem2005，10，8： | 1 |
| 19 | Pro-survival effects of repetitive low-grade oxidative stress are inhibited by simultaneous exposure to resveratrol 显示文摘 | Chakraborty PK Mustafi SB Raha S | 2008 | Pharmacol Res2008，58，56： | 1 |
| 20 | Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators显示文摘 | Cerda S R Mustafi R Little H | 2006 | Oncogene2006，25，22： | 1 |
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