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| 1 | Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease显示文摘In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive drugs.The cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening hepatitis.The development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical settings.On this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at risk.However,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical settings.The published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting results.Thus,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence. | Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 2 | Sustained virological response: A milestone in the treatment of chronic hepatitis C显示文摘AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples 'Federico Ⅱ'. At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33% survival rate in our cohort of patients after therapy for HCV infection. Finally, of the 27 patients who underwent a liver biopsy at the beginning of the study, a reduction in liver fibrosis was observed in 70.3% of the cases; only three cases registering values of liver stiffness indicative of significant fibrosis. CONCLUSION: Patients with CHC and SVR show an excellent prognosis with no risk of recurrence and a very low rate of mortality. Our data indicate that viruseradication following interferon treatment can last up to 20 years. | Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma Nicola Caporaso | 2013 | World Journal of Gastroenterology2013，19，18： | 4 |
| 3 | Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows显示文摘With the introduction of direct-acting antiviral agents(DAA), the rate of sustained virological response(SVR) in the treatment of hepatitis C virus(HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma(HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4%(maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4%(maximum 'not well-defined' followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection. | Maria Guarino Anna Sessa Valentina Cossiga Federica Morando Nicola Caporaso Filomena Morisco | 2018 | World Journal of Gastroenterology2018，24，24： | 2 |
| 4 | Increased cardiomyocyte apoplosisand changes in proapoptotic and antiapoptotic genes bax and hcl-2 duringleft ventricular adaptations to chronic pressure overload in the rat 显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，23： | 1 |
| 5 | Consensus recommendations for managing asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels:suggestions for diagnostic procedures and monitoring显示文摘 | Morisco F Pagliaro L Caporaso N | 2008 | Dig Liver Dis2008，40，： | 1 |
| 6 | The akt-glycogen synthase kinase 3 pathway regulates transcription of atrial natriuretic factor induced by-adrenergic receptor stimulation in cardiac myocytes显示文摘 | Morisco C Zebrowski D Condorelli G | 2000 | J Biol Cardio2000，275，14： | 1 |
| 7 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat 显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，： | 1 |
| 8 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overloaded in the rat显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，23： | 1 |
| 9 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat 显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，： | 1 |
| 10 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl - 2 during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，23： | 1 |
| 11 | Increased cardiomyocyte apopto- sis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventri('utar adaptations to chronic pressurre overloaded in the rat 显示文摘 | Condorclli G Morisco C Slassi G | 1999 | Circulation1999，99，23： | 1 |
| 12 | The addition of ribavirin to interferon-a therapy in patients with hepatitis C virus-related chronichepatitis does not modify the thyroid autoantibody pattern but increases the risk of developing hypothyroidism显示文摘 | Carella C Mazziotti G Morisco F | 2002 | Eur J Endocrinol2002，146，6： | 1 |
| 13 | Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphetmls and melanoidins显示文摘 | Vitagliane P Morisco F Mazzcne G | 2010 | Hepatology2010，，52： | 1 |
| 14 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，： | 1 |
| 15 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat 显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，： | 1 |
| 16 | The Akt-glycogen synthase kinase 3β pathway regulates transcription atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes显示文摘 | Morisco C Zebroski D Condorelli G Tsichlis P Vatner SF Sadoshima J | 2000 | J Biol Chem2000，275，14： | 1 |
| 17 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Condorelli G Morisco C Stassi G | 1999 | Circulation1999，99，23： | 1 |
| 18 | Insulin resistance and cardiovascular risk:new insights from molecular and cellular biology显示文摘 | Morisco C Lembo G Trimarco B | 2006 | Trends Cardiovasc Med2006，16，： | 1 |
| 19 | Serum insulinlike growth factor1 evaluation as a useful tool for predicting the risk of developing hepatocellular carcinoma in patients with hepatitis c virusrelated cirrhosis显示文摘 | Mazzioti G Sorvillo F Morisco F | 2002 | Cancer2002，95，： | 1 |
| 20 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Condorelli G Morisco C | 1999 | Circulation1999，99，： | 1 |
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