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| 1 | Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats显示文摘Neuropathic pain after spinal cord injury(SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy;nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the ability of fetal neural stem cells(fNSC) to relieve chronic pain and, secondarily, their effects on motor recovery. Adult Wistar rats with traumatic SCI were treated, 10 days after injury, with intra-spinal injections of culture medium(sham) or fNSCs extracted from telencephalic vesicles(TV group) or the ventral medulla(VM group) of E/14 embryos. Sensory(von Frey filaments and hot plate) and motor(the Basso, Beattie,Bresnahan locomotor rating scale and inclined plane test) assessments were performed during 8 weeks. Thereafter, spinal cords were processed for immunofluorescence and transplanted cells were quantified by stereology. The results showed improvement of thermal hyperalgesia in the TV and VM groups at 4 and 5 weeks after transplantation, respectively. Moreover, mechanical allodynia improved in both the TV and VM groups at 8 weeks. No significant motor recovery was observed in the TV or VM groups compared with sham. Stereological analyses showed that ~70% of TV and VM cells differentiated into NeuN+ neurons,with a high proportion of enkephalinergic and GABAergic cells in the TV group and enkephalinergic and serotoninergic cells in the VM group. Our study suggests that neuronal precursors from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal subtypes, mainly GABAergic, serotoninergic, and enkephalinergic, and all subtypes alleviate pain, despite no significant motor recovery. The study was approved by the Animal Ethics Committee of the Medical School of the University of S?o Paulo(protocol number 033/14) on March 4, 2016. | Chary M. Batista Eric D. Mariano Camila S. Dale Alexandre F. Cristante Luiz R. Britto Jose P. Otoch Manoel J. Teixeira Matthias Morgalla Guilherme Lepski | 2019 | Neural Regeneration Research2019，14，11： | 3 |
| 2 | Do antibioticimpregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients 显示文摘 | RITZ R ROSER F MORGALLA M | 2007 | BMC Infect Dis2007，7，： | 1 |
| 3 | Lumbar spinalstenosis in elderly patients:is a unilateral microsurgical ap-proach sufficient for decompression?显示文摘 | MORGALLA MH NOAK N MERKLE M | 2011 | Neurosurg Spine2011，14，3： | 1 |
| 4 | Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure显示文摘AIM To investigate the changes of hemodynamic and laboratory parameters during the course of acute liver failure following acetaminophen overdose.METHODS Eight pigs underwent a midline laparotomy following jejunal catheter placement for further acetaminophen intoxication and positioning of a portal vein Doppler flow-probe. Acute liver failure was realized by intrajejunal acetaminophen administration in six animals, two animals were sham operated. All animals were invasively monitored and received standardized intensive care support throughout the study. Portal blood flow, hemodynamic and ventilation parameters were continuously recorded. Laboratory parameters were analysed every eight hours. Liver biopsies were sampled every 24 h following intoxication and upon autopsy.RESULTS Acute liver failure (ALF) occurred after 28 ± 5 h resulted in multiple organ failure and death despite maximal support after further 21 ± 1 h (study end). Portal blood flow (baseline 1100 ± 156 m L/min) increased to a maximum flow of 1873 ± 175 m L/min at manifestation of ALF, which was significantly elevated(P < 0.01). Immediately after peaking, portal flow declined rapidly to 283 ± 135 m L/min at study end. Thrombocyte values (baseline 307 × 103/μL± 34 × 103/μL) of intoxicated animals declined slowly to values of 145 × 103/μL± 46 × 103/μL when liver failure occurred. Subsequent appearance of severe thrombocytopenia in liver failure resulted in values of 11 × 103/μL± 3 × 103/μL preceding fatality within few hours which was significant(P > 0.01).CONCLUSION Declining portal blood flow and subsequent severe thrombocytopenia after acetaminophen intoxication precede fatality in a porcine acute liver failure model. | Karolin Thiel Wilfried Klingert Kathrin Klingert Matthias H Morgalla Martin U Schuhmann Pamela Leckie Yalda Sharifi Nathan A Davies Rajiv Jalan Andreas Peter Christian Grasshoff Alfred Konigsrainer Martin Schenk Christian Thiel | 2017 | World Journal of Gastroenterology2017，23，9： | 1 |
| 5 | Tumor-related venous obstruction and development of peritumoral brain edema in meningiomas显示文摘 | Bitzer M Topka H Morgalla M | 1998 | Neurosurgery1998，42，： | 1 |
| 6 | Peritumoural brain oedema in intracranial meningiomas: influence of tumor size, location and histology显示文摘 | Bitzer M Wockel L Morgalla M | 1997 | J Acta Neurochir (Wien)1997，139，12： | 1 |
| 7 | Lumbar spinal stenosisin elderly patients:is a unilateral microsurgical approach suffi-cient for decompression?显示文摘 | Morgalla MH Noak N Merkle M | 2011 | J Neurosurg Spine2011，14，3： | 1 |
| 8 | Lumbar spinal stenosis in elderly patients:is a unilateral microsurgical ap-proach sufficient for decompression?显示文摘 | Morgalla MH Noak N Merkle M | 2011 | Neurosurg Spine2011，14，3： | 1 |
| 9 | Thin and thick filament regulation of contractility in experimental cerebral vasospasm显示文摘 | Kim I Leinweber BD Morgalla M | 2000 | Neurosurgery2000，46，： | 1 |
| 10 | Repeated decompressive craniectomy after head injury in childron : two successful eases as result of improved neuromonitofing显示文摘 | Morgalla MH Krasznai L Buchholz R | 1995 | Surg Neurol1995，43，6： | 1 |
| 11 | Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients显示文摘 | Ritz R Roser F Morgalla M | 2007 | BMC Infect Dis2007，7，： | 1 |
| 12 | Lumbar spinal stenosis in elderly patients: is a unilateral mierosurgieal approach sulfSieient for decompression? 显示文摘 | Morgalla MH Noak N Merkle M | 2011 | J Neurosurg Spine2011，14，3： | 1 |
| 13 | Thin and thick filament regulation of contractility in experimental cerebral vasospasm显示文摘 | Kim I Leinweber BD Morgalla M | 2002 | Neurosurgery2002，46，2： | 1 |
| 14 | Lumbar spinal stenosis in elderly patients: is a unilateral microsurgical approach sufficient for decom- pression显示文摘 | Morgalla MH Noak N Merkle M | 2011 | J Neurosurg2011，14，3： | 1 |
| 15 | Repeated decompressive craniectomy often head injury in children显示文摘 | Morgalla MH Krasznai L Buchhol ZR | 1996 | Surg Neurol1996，43，： | 1 |
| 16 | Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients 显示文摘 | Ritz R Roser F Morgalla M | 2007 | BMC Infect Dis2007，5，8： | 1 |
| 17 | Lumbar spinal stenosis inelderly patients:is a unilateral microsurgical approach sufficient fordecompression显示文摘 | Morgalla MH Noak N Merkle M | 2011 | J Neurosurg Spine2011，3，： | 1 |
| 18 | Thin and thick filament regulation of contractility in experimental cerebral vasospasm 显示文摘 | Kim I Leinweber BD Morgalla M | 2000 | Neurosurgery2000，46，2： | 1 |
| 19 | Repeated deeompres- sive eranieetomy after head injury in children: two successful eases as result of improved neuromonitoring 显示文摘 | Morgalla MH Krasznai L Buchholz R | 1995 | Surg Neurol1995，43，6： | 1 |
| 20 | Peritumoural brain oedema in intracranial meningiomas:influence of tumor size,location and histology显示文摘 | Bitzer M Wockel L Morgalla M | 1997 | Acta Neurochir (Wien)1997，139，12： | 1 |
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