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| 1 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 2 | QT prolongation is associated with increased mortality in end stage liver disease显示文摘AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and mortality.METHODS The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females.Multiple clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients. | Sun Moon Kim Bennet George Diego Alcivar-Franco Charles L Campbell Richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey | 2017 | World Journal of Cardiology2017，9，4： | 3 |
| 3 | Revascularization of ische mic tissues by PDGF-CC via effects on endothelial cells and their progenitors显示文摘 | Li X Tjwa M Moons L | 2005 | J Clin Invest2005，115，1： | 1 |
| 4 | Prediction of stroke in the general population in Europe (EUROSTROKE) : Is there a role f or fibfinogen and electrocardiography显示文摘 | MOONS K C BOTS M L SABONEN J T | 2002 | J Epidemi- ol Community Health2002，56，： | 1 |
| 5 | Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase显示文摘 | Moon K D Post C B Durden D L | 2005 | J Biol Chem2005，280，2： | 1 |
| 6 | Relationships among self-efficacy,outcome expectancy, and postoperative behaviors in total joint replacement patients显示文摘 | Moon L B Backer J | 2000 | Orthop Nurs2000，19，2： | 1 |
| 7 | Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation显示文摘 | Carmeliet P Moons L Lijnen R | | 0，，04： | 1 |
| 8 | Ittakes a village to grow a tissue显示文摘 | KAPLAN D L MOON R T VUNJAK-NOVAKOVIC G | | 0，，： | 1 |
| 9 | Synergism between vascular growthendothelial faetor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions显示文摘 | Carmeliet P Moons L Luttun A | 2001 | Nat Med2001，7，5： | 1 |
| 10 | Ionic Conduction in the Gd2Ti2O7-Gd2Zr2O7 System显示文摘 | Moon P K Tuller H L | 1988 | Solid State Ionics1988，2830，1： | 1 |
| 11 | Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration显示文摘 | Oosthuyse B Moons L Storkebaum E | 2001 | Nat Genet2001，28，： | 1 |
| 12 | Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer:implications for the clinical management of intervertebral disc disorders显示文摘 | MOON S H GILBERTSON L G NISHIDA K | 2000 | Spine2000，25，20： | 1 |
| 13 | Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter caused motor neuron degeneration 显示文摘 | B Oosthuyse L Moons E Storkebaum | 2001 | Nat Genet2001，28，： | 1 |
| 14 | Neuroprotective Effect of Ghrelin in the 1-Methyl- 4-Phenyl-1, 2, 3, 6-Tetrahydropyridine Mouse Model of Parkinson' s Disease by Blocking Microglial Activation 显示文摘 | MOON M KIM H G HWANG L | 2009 | Neurotox Res2009，15，： | 1 |
| 15 | Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma- H2 AX and suppresses DNA double strand break repair 显示文摘 | Moon SH Lin L Zhang X | 2010 | J Bioi Chern2010，285，12： | 1 |
| 16 | A RFID case-based Sample Management System for Fash ion Product Development显示文摘 | Choy K L Chow K H Moon K L | 2009 | Engineering Applica tions of Artificial Intelligence2009，22，88： | 1 |
| 17 | Benign and malignantthyroid nodules: US differentiation--multicenter retrospectivestudy 显示文摘 | MOON W J JUNG S L LEE J H | 2008 | Radiology2008，247，3： | 1 |
| 18 | Association of polymorphisms in monocyte ehemoattractant protein-1 promoter with diabet- ic kidney failure in Korean patients with type 2 diabetes mellitas显示文摘 | Moon JY Jeong L Lee S | 2007 | J Korean Med Sci2007，22，5： | 1 |
| 19 | Recent developments in the preparation and properties of nanometer-size spherical and platelet-shaped particles and composite particles 显示文摘 | ADAIR J H LI T KIDO T HAVEY K MOON J MECHOLSKY J MORRONE A TALHAM D R LUDWIG M H WANG L | 1998 | Mater Sci Eng R1998，23，45： | 1 |
| 20 | Use of fluorodeoxyglucose positron emission tomography in patients with rare head and neck cancers显示文摘 | ROH J L MOON B J KIM J S | 2008 | Clin Exp Otorhinolaryngol2008，1，2： | 1 |
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