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| 1 | Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease:the PINK1/CHCHD4 interplay显示文摘Parkinson’s disease(PD)is a common movement disorder of the elderly caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the brain.Both environmental and genetic factors pointed out mitochondrial dysfunction as a major cause of neurodegeneration in PD.Pioneering studies using mitochondrial toxins revealed their ability to trigger dopaminergic cell death and irreversible parkinsonism in different animal models(Poewe et al.,2017).Typical features of mitochondrial dysfunction have been also observed in the human brain of idiopathic PD cases,showing alterations of respiratory chain complex I and IV activity,accumulation of mtDNA deletions and increased oxidative stress(Bender et al.,2006).Moreover,a number of genes found mutated in familial PD forms encode for proteins involved in the maintenance of mitochondrial homeostasis and quality control.Among these,the PINK1 gene encodes a mitochondrial serine/threonine kinase implicated in key neuroprotective functions,including mitophagy,regulation of mitochondrial transport,control of the mitochondria/endoplasmic reticulum crosstalk and calcium homeostasis(Brunelli et al.,2020). | Giuseppe Arena Nazanine Modjtahedi Rejko Kruger | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 2 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 3 | The cotranslocation of ERp57 and calreticulin deter mines the immunogenicity of eell death 显示文摘 | Panaretakis T Joza N Modjtahedi N | 2008 | Cell Death Differ2008，15，9： | 1 |
| 4 | Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells 显示文摘 | Charoenrat P Modjtahedi H Rhys P | 2000 | Cancer Res2000，60，4： | 1 |
| 5 | Screening for hydroxychloruquine toxicity in children显示文摘 | Modjtahedi BS Movassagh N Gandhi N | 2013 | Cutan Ocul Toxicol2013，32，4： | 1 |
| 6 | Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells显示文摘 | O-charoenrat P Rhys-Evans P Modjtahedi H | 2000 | Clin Exp Metastasis2000，18，2： | 1 |
| 7 | Apoptosis-inducing factor:vital and lethal显示文摘 | Modjtahedi N Giordsnetto F Madeo F | 2006 | Trends Cell Biol2006，16，5： | 1 |
| 8 | Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells 显示文摘 | Modjtahedi H Rhys-Evans P | 2000 | Cancer Res2000，60，4： | 1 |
| 9 | Production of a novel camel single-domain antibody specific for the type Ⅲ mutant EGFR显示文摘 | Omidfar K Rasaee MJ Modjtahedi H | 2004 | Tumour Biol2004，25，56： | 1 |
| 10 | Epidermal growth factor receptor inhibitors in cancer treatment:advances,challenges and opportunities显示文摘 | MODJTAHEDI H ESSAPEN S | 2009 | Anticancer Drugs2009，20，10： | 1 |
| 11 | Epidermal growth factor like ligands differentially up-regulate matrix metalloproteinase-9 in head and neck squamous carcinoma ceils 显示文摘 | Charoenrat P Modjtahedi H Rhys P | 2000 | Cancer Res2000，60，4： | 1 |
| 12 | Pharmacological treatments for thyroid eye disease显示文摘 | MODJTAHEDI S P MODJTAHEDI B S MANSURY A M | 2006 | Drugs2006，66，13： | 1 |
| 13 | Epidermal growth factor - like ligands differentially up - regulate matrx metalloproteinase 9 in head and neck squamous carcinoma cells 显示文摘 | Charoenrat P Modjtahedi H Rhys P | 1993 | Cancer Res1993，53，1： | 1 |
| 14 | Apoptosis - inducing factor : vital and lethal 显示文摘 | Modjtahedi N Giordanetto F Madeo F | 2006 | Trends Cell Biol2006，16，5： | 1 |
| 15 | Epidermal growth factor receptor inhibitors in cancer treatment: advances challenges and op- portunities 显示文摘 | Modjtahedi H Essapen S | 2009 | Anticancer Drugs2009，20，10： | 1 |
| 16 | Epi- dermal growth factor-like ligands differentially up-regu- late matrix metalloproteinase 9 in head and neck squa- mous carcinoma cells显示文摘 | Ocharoenrat P Modjtahedi H Rhys-Evans P | 2000 | Cancer Res2000，60，4： | 1 |
| 17 | Apoptosis-inducing factor:vital and lethal显示文摘 | Modjtahedi N Giordanetto F Madeo F | 2006 | Trends Cell Biol2006，16，5： | 1 |
| 18 | Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells显示文摘 | Modjtahedi H Rhys P | 2000 | Cancer Res2000，60，4： | 1 |
| 19 | Epidermal growth factor - like ligands differentially up - regulate matrix metallo- proteinase 9 in head and neck squamous carcinoma cells 显示文摘 | O - charoenrat P Modjtahedi H Rhys - Evans P | 2000 | Cancer Res2000，60，4： | 1 |
| 20 | Ethnieity as a possible endogenous factor in irritant contact dermatitis: comparing the irritant response among Caucasians, blacks, and Asians显示文摘 | MODJTAHEDI S P MAIBACH H I | 2002 | Contact Dermatitis2002，47，： | 1 |
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