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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Nutritional support and infection: Does the route matter显示文摘 | Minard G Kudsk KA | 1998 | World J Surg1998，22，2： | 1 |
| 3 | Tiam1 is overexpressed in human colorectal tumors显示文摘 | Minard ME Ellis LM Gallick GE | 2005 | AACR Meeting Abstracts2005，46，： | 1 |
| 4 | Is early feeding beneficial? How early is early?显示文摘 | MINARD G KUDSK K A | 1994 | New Horiz1994，2，： | 1 |
| 5 | Helicobacter species and liver diseases: association or causation显示文摘 | PELLICANO R MINARD A RIZZETI'O M | 2008 | Lancet In- fect Dis2008，8，4： | 1 |
| 6 | Staged Management of Giant Abdominal Wall Defects: Acute and Long-Term Results显示文摘 | T. Wright Jernigan Timothy C. Fabian Martin A. Croce Natalie Moore F. Elizabeth Pritchard Gayle Minard Tiffany K. Bee | 2003 | Annals of Surgery2003，，3： | 1 |
| 7 | Mecha- nisms and parameters controlling the tricalcium aluminate re- activity in the presence of gypsum 显示文摘 | MINARD H GARRAULT S REGNAUD L | 2007 | Cem Concr Res2007，37，： | 1 |
| 8 | The role of the guanine nucleotide exchange factor Tiaml in cellular migration,invasion,adhesion and tumor progression显示文摘 | Minard M E Kim L S Price J E | 2004 | Breast Cancer Res Treat2004，84，： | 1 |
| 9 | Use of high resolution 13C-NMR to examine the enzymatic covalent binding of 13C-labeled 2,4-dichlorophenol to humic substances 显示文摘 | HATCHER P G BORTIAYNSKI J M MINARD R D | 1993 | Environmental Science & Technology1993，27，10： | 1 |
| 10 | Over-expression of Bcl- 2 provides protection in septic mice by a trans effect显示文摘 | Iwata A Stevenson VM Minard A | 2003 | J Immunol2003，171，6： | 1 |
| 11 | Lowserum total calcium concentration as a marker of low serum ionizedcalcium concentration in critically ill patients receiving specializednutrition support显示文摘 | Dickerson RN Henry NY Miller PL Minard G Brown RO | 2007 | Nutr Clin Pract2007，22，3： | 1 |
| 12 | Is early feeding benefices?How early is early?显示文摘 | Kudsk KA | 1994 | New Horiz1994，2，2： | 1 |
| 13 | Mechanisms and parameters controlling the tricalcium aluminate reactivity in the presence of gypsum显示文摘 | Minard H Garrault S Regnaud L | 2007 | Cement and Concrete Research2007，37，10： | 1 |
| 14 | Generalization of shift-and-add imaging 显示文摘 | R H T Bates A M Sinton R A Minard | 1985 | International Conference on Speckle1985，556，： | 1 |
| 15 | The role of the Gua- nine nucleotide exchange factor tiaml in cellular migra- tion,invasion,adhesion and tumor progression 显示文摘 | Minard ME Kim LS Price JE | 2004 | Breast Cancer Res Treat2004，84，1： | 1 |
| 16 | Is early feeding beneficial? How early is e&rly显示文摘 | Minard q Kudsk KA | 1994 | New Horiz1994，2，： | 1 |
| 17 | The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model显示文摘 | Minard M E Herynk M H Collard J G | 2005 | Oncogene2005，24，15： | 1 |
| 18 | Allostefic inhibition of NAD^+-specific isocitrate dehydrogenase by a mitochondrial mRNA显示文摘 | Anderson SL Minard KL McAlister-Henn L | 2000 | Biochemistry2000，39，： | 1 |
| 19 | Is eary teeding beneficical howearly is earlyu new hori 显示文摘 | Minard G kudsk KA | 1994 | 2(2) :156-1631994，2，2： | 1 |
| 20 | Mechanisms andparameters controlling the tricalcium aluminate reactivityin the presence of gypsum 显示文摘 | Minard H Garraults Regnaud L | 2007 | Cem Concr Res2007，37，10： | 1 |
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